Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion - Full Text View

Sponsored by:	University of Zurich
Information provided by:	University of Zurich
ClinicalTrials.gov Identifier:	NCT00526695

Purpose

Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury.

Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against ischemia/reperfusion injury and reduces inflammatory markers in the circulation

Condition	Intervention	Phase
Ischemia/Reperfusion Injury	Drug: Sevoflurane (Preconditioning)	Phase IV

MedlinePlus related topics: Anesthesia

Drug Information available for: Sevoflurane

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Open Label, Active Control, Crossover Assignment, Safety/Efficacy Study
Official Title:	Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion, Leukocyte/Thrombocyte Activation, and Endothelial Function After Tourniquet-Induced Ischemia/Reperfusion Injury in the Forearm of Volunteers

Further study details as provided by University of Zurich:

Primary Outcome Measures:

marker expression on blood cells [ Time Frame: December 2008 ] [ Designated as safety issue: No ]

Estimated Enrollment:	10
Study Start Date:	January 2005
Estimated Study Completion Date:	December 2008
Estimated Primary Completion Date:	December 2008 (Final data collection date for primary outcome measure)

Intervention Details:

Inhalation of sub-anesthetic doses of sevoflurane

Detailed Description:

Healthy volunteers are included in the study to investigate endothelial function and platelet activation after preconditioning by sevoflurane in subanesthetic concentrations.

Forearm perfusion, endothelial function and leukocyte/thrombocyte activation after tourniquet-induced ischemia/reperfusion injury of the forearm are measured using healthy volunteers in a cross-over design.

Eligibility

Ages Eligible for Study:	25 Years to 45 Years
Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion criteria: male

Non-smoker
No asthma
NPO
Volunteer

Exclusion criteria:

Female
Chronic medication
Asthma
Smoking

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00526695

Contacts

Contact: 01 Studienregister MasterAdmins

+41 (0)44 255 11 11

Locations

Switzerland
University Hospital of Zurich	Recruiting
Zurich, Switzerland
Contact: Michael Zaugg, MD michael.zaugg@usz.ch
Principal Investigator: Michael Zaugg, MD

Sponsors and Collaborators

University of Zurich

Investigators

Principal Investigator:	Michael Zaugg, PD Dr. med.	UniversitaetsSpital Zuerich
Principal Investigator:	Michael Zaugg, PD Dr. med.	University of Zurich

More Information

Responsible Party:	Anesthesiology, Univ. Hospital Zurich ( Michael Zaugg )
Study ID Numbers:	17-2005
Study First Received:	August 27, 2007
Last Updated:	July 17, 2008
ClinicalTrials.gov Identifier:	NCT00526695
Health Authority:	Switzerland: Swissmedic

Keywords provided by University of Zurich:

Ischemia/Reperfusion
Organ Protection
Anesthetics

Study placed in the following topic categories:

Postoperative Complications
Vascular Diseases
Ischemia
Sevoflurane
Reperfusion Injury

Additional relevant MeSH terms:

Anesthetics, Inhalation
Pathologic Processes
Anesthetics, General
Therapeutic Uses
Physiological Effects of Drugs
Hematologic Agents

Central Nervous System Depressants
Anesthetics
Platelet Aggregation Inhibitors
Cardiovascular Diseases
Central Nervous System Agents
Pharmacologic Actions

ClinicalTrials.gov processed this record on January 14, 2009