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| Sponsored by: |
National Institute of Environmental Health Sciences (NIEHS) |
|---|---|
| Information provided by: | National Institutes of Health Clinical Center (CC) |
| ClinicalTrials.gov Identifier: | NCT00339976 |
Purpose
This study is a follow-up to an earlier study that examined the relationship of This study will examine whether exposure to neurotoxins, such as lead, mercury, solvents, and pesticides, can contribute to amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. The cause of this degenerative disease of the brain and spinal cord is not well understood. Some studies suggest that exposure to environmental neurotoxins may increase its risk. This follow-up study will examine the relationship of neurotoxin exposure to the interval between the diagnosis of ALS and death. It will also examine the possible roles of genetics, lifestyle and dietary factors in the disease. Information on ALS patients previously enrolled in the study will be used to examine this relationship. No new individuals will be enrolled in the study.
| Condition |
|---|
|
Amyotrophic Lateral Sclerosis ALS |
| Study Type: | Observational |
| Official Title: | Ascertainment of Death in ALS Patients |
| Estimated Enrollment: | 0 |
| Study Start Date: | August 2002 |
| Estimated Study Completion Date: | April 2008 |
Objective: The objective of this proposal is linkage with the National Death Index (NDI) for cases from a study that was conducted in the early 1990's. The purpose of the initial study was to examine the role that lead and other exposures, including mercury and solvents, play in the etiology of amyotrophic lateral sclerosis (ALS).
Study population: The study involved 110 ALS cases and 256 population based controls, recruited in New England between 1993 and 1996. Data collection involved an interview, blood collection, and measurement of bone lead using x-ray fluorescence.
Design and outcome parameters: The results of this study suggested that lead exposure was a risk factor for ALS. Compared to controls, cases were more likely to have occupational lead exposure, and both blood and bone lead levels were higher in cases. We are presently analyzing data on other neurotoxic exposures including mercury, solvents, and pesticides. In order to investigate prognosis, we would like to determine the date of death by searching the National Death Index. This information will enable us to evaluate the relationship of neurotoxic exposures to ALS prognosis.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
The purpose of the NDI search will be to verify death and obtain date and cause of death information for the study participants.
Contacts and Locations More Information
| Study ID Numbers: | 999902275, 02-E-N275 |
| Study First Received: | June 19, 2006 |
| Last Updated: | April 22, 2008 |
| ClinicalTrials.gov Identifier: | NCT00339976 |
| Health Authority: | United States: Federal Government |
|
Case-Control Study Death Certificates National Death Index Cause of Death Information |
Lead Exposure Amyotrophic Lateral Sclerosis ALS |
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Death Amyotrophic lateral sclerosis Neuromuscular Diseases Spinal Cord Diseases Amyotrophic Lateral Sclerosis Central Nervous System Diseases |
Lou Gehrig's disease Sclerosis Degenerative motor system disease Neurodegenerative Diseases Motor neuron disease Motor Neuron Disease |
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Pathologic Processes Nervous System Diseases |
