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Sponsors and Collaborators: |
National Cancer Institute (NCI) National Center on Minority Health and Health Disparities (NCMHD) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00339534 |
This study, conducted at Korle-Bu Hospital in Accra, Ghana, will help elucidate the roles of lifestyle and genetic factors in prostate cancer risk. There is a strong variation in risk of prostate cancer throughout the world. The rates of the disease among African Americans are some of the world's highest. In the United States, the incidence of prostate cancer is 70 percent higher in African Americans than in white Americans and the death rate in African Americans is almost double that of white Americans. The reasons for this excessive risk are unknown, but both genetic and lifestyle factors have been suggested.
Because Africans and African Americans share similar genetic ancestry but have vastly different lifestyles, a better understanding of the rates and risk factor profiles for prostate cancer among Africans will provide important clues to what causes the disease. This study will try to assess the incidence of prostate cancer in the West African nation of Ghana. The study has two components:
The clinical survey will use data from the cancer logbook and medical records at Korle-Bu Hospital and the Ghanaian National Census to derive an estimate of prostate cancer incidence within Accra. The estimate will be low, since it will be based only on men diagnosed or treated at Korle-Bu and will not include men with asymptomatic disease, men diagnosed elsewhere, or men without access to medical care. The screening and detection survey will assess the presence of asymptomatic and unrecognized symptomatic prostate cancer using PSA testing and digital rectal examination in a random sample of 1,000 men in the general population of Accra. This will provide a high estimate of disease prevalence. The two estimates will provide an approximation of the true incidence rate of the disease in Accra.
Comparison of these data with similar data from community surveys of African Americans will provide insight into reasons for the excess risk of prostate cancer in African Americans.
Condition |
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Prostate Cancer |
Study Type: | Observational |
Official Title: | Survey of Prostate Cancer in Accra, Ghana |
Estimated Enrollment: | 1600 |
Study Start Date: | June 2002 |
The key aim of this study is to assess the burden of prostate cancer in Ghana to evaluate how the impact of prostate cancer among West Africans compares to that among African-Americans, whose reported incidence rates are among the highest in the world. West Africans and African-Americans share genetic ancestry but have very different lifestyle and environmental exposures. The study aim will be achieved by deriving lower and upper bounds on the true incidence of prostate cancer in the capital city of Accra.
Ages Eligible for Study: | 50 Years to 74 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
The 1,000 Accra residents selected for screening will include 300 men 50-59, 400 men 60-69, and 300 men 70-74 years of age.
EXCLUSION CRITERIA:
Men who do not meet the age requirements will be excluded from the study.
In addition, men who have a history of prostate cancer for which they have received treatment will also be excluded (men with untreated prostate cancer will be included).
Contact: Ann Hsing, Ph.D. | (301) 435-3980 | hsinga@exchange.nih.gov |
United States, District of Columbia | |
GW University Medical Center GW Hospital Center | Recruiting |
Washington, District of Columbia, United States, 20037 | |
United States, Maryland | |
Johns Hopkins University | Recruiting |
Baltimore, Maryland, United States, 21205 | |
United States, North Carolina | |
Research Triangle Institute/Office of Research Protection and Ethics | Recruiting |
Research Triangle Park, North Carolina, United States, 27709 | |
Ghana | |
University of Ghana | Recruiting |
Legon, Accra, Ghana | |
Korle-Bu Teaching Hospital | Recruiting |
Accra, Ghana |
Study ID Numbers: | 999902240, 02-C-N240 |
Study First Received: | June 19, 2006 |
Last Updated: | July 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00339534 |
Health Authority: | United States: Federal Government |
Epidemiology Africa Urology Cancer Incidence |
Black-White Health Disparities Cancer Prostate Cancer |
Prostatic Diseases Genital Neoplasms, Male Urogenital Neoplasms Genital Diseases, Male Prostatic Neoplasms |
Neoplasms Neoplasms by Site |