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Sponsored by: |
Vanderbilt University |
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Information provided by: | Vanderbilt University |
ClinicalTrials.gov Identifier: | NCT00338065 |
Our experiments are designed to test the overall hypothesis that position-dependent IOP spikes occur in humans, and that these challenge ocular homeostasis.
Condition |
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Intraocular Pressure |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | External Influences Upon Ocular Homeostasis |
Estimated Enrollment: | 100 |
Study Start Date: | June 2006 |
Estimated Study Completion Date: | December 2009 |
Glaucoma is the second leading cause of blindness in the United States, yet its pathogenesis is poorly understood. This is an insidious disorder since the loss of peripheral vision which occurs first usually is not noticed by the victim. Approximately 1 million people in the United States have glaucoma, but are not aware of it. Glaucoma is not always associated with elevated intraocular pressures so that vision screenings which measure just intraocular pressure without assessing the optic nerve will also miss these patients with glaucomatous damage. Therefore, patients are often diagnosed only when they have severe irreversible vision loss. Vascular insufficiency or abnormal autoregulation versus mechanical pressure damage has been proposed as a major factor in the development of glaucoma. Presently, therapy is based upon lowering intraocular pressure. If a contributing intermittent pressure elevation factor can be elucidated and characterized, specific treatment modalities may then be developed and their effectiveness can be monitored.
Ages Eligible for Study: | 50 Years to 90 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
The main purpose of this study is to find out the importance of the involuntary (autonomic) nervous system, blood pressure in the arteries and the veins, postural position, and externally applied pressure on the functions of the eye.
involuntary (autonomic) nervous system, blood pressure in the arteries and the
Inclusion Criteria:
Exclusion criteria:
Contact: Karen Joos, MD | 615-936-2020 | |
Contact: Sandy Owings, COA | 615-936-3465 | sandy.owings@vanderbilt.edu |
United States, Tennessee | |
Vanderbilt University | Recruiting |
Nashville, Tennessee, United States, 37232 | |
Contact: Sandy Owings, COA 615-936-3465 Sandy.owings@vanderbilt.edu | |
Principal Investigator: Karen Joos, MD |
Principal Investigator: | Karen Joos, MD | Vanderbilt Eye Institute |
Responsible Party: | Karen Joos, MD, Ph.D ( Karen Joos, MD, Ph.D ) |
Study ID Numbers: | Vanderbilt IRB# 010436 |
Study First Received: | June 15, 2006 |
Last Updated: | November 4, 2008 |
ClinicalTrials.gov Identifier: | NCT00338065 |
Health Authority: | United States: Food and Drug Administration |
Intraocular Pressure |