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Sponsors and Collaborators: |
Radboud University ZonMw: The Netherlands Organisation for Health Research and Development |
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Information provided by: | Radboud University |
ClinicalTrials.gov Identifier: | NCT00132106 |
The activity of the sympathetic nervous system seems to influence the uptake (and handling) of glucose by the skeletal muscle of the forearm. Conditions in which sympathetic activity is increased seem to inhibit/reduce forearm glucose uptake. Inversely a decrease in sympathetic activity seems to increase glucose uptake. This study analyzes the effect of alfa-adrenergic receptor blockade (counteracting sympathetic influence) on insulin-stimulated forearm glucose uptake in patients with increased sympathetic activity (patients with chronic heart failure).
Condition | Intervention |
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Heart Failure, Congestive |
Drug: phentolamine |
Study Type: | Interventional |
Study Design: | Non-Randomized, Open Label, Active Control, Single Group Assignment |
Official Title: | The Effect of a-Adrenergic Receptor Blockade on Insulin-Stimulated Forearm Glucose Uptake and Metabolism in Chronic Heart Failure |
Ages Eligible for Study: | 18 Years to 75 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Marc E.R. Gomes, MD | +31-24-3614533/3616550 | m.gomes@cardio.umcn.nl |
Netherlands | |
Radboud University Nijmegen Medical Centre | Recruiting |
Nijmegen, Netherlands, 6500 HB | |
Contact: Marc ER Gomes, MD 31-24-3614533/3616550 m.gomes@cardio.umcn.nl | |
Sub-Investigator: Marc ER Gomes, MD | |
Sub-Investigator: Alexandra H Mulder, MD | |
Sub-Investigator: Freek WA Verheugt, MD, PhD | |
Sub-Investigator: Paul Smits, MD, PhD | |
Principal Investigator: Cees J Tack, MD, PhD | |
Sub-Investigator: Louise Bellersen, MD |
Principal Investigator: | Cees J Tack, MD, PhD | Radboud University |
Study ID Numbers: | CHFALFA |
Study First Received: | August 18, 2005 |
Last Updated: | August 30, 2007 |
ClinicalTrials.gov Identifier: | NCT00132106 |
Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
Phentolamine Heart Failure Heart Diseases Insulin |
Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Adrenergic Agents Therapeutic Uses Physiological Effects of Drugs Adrenergic Antagonists |
Cardiovascular Diseases Adrenergic alpha-Antagonists Cardiovascular Agents Antihypertensive Agents Pharmacologic Actions |