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Sponsors and Collaborators: |
National Heart, Lung, and Blood Institute (NHLBI) University of California, San Francisco |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00451919 |
Sickle cell disease is an inherited blood disorder that affects red blood cells (RBCs). People with sickle cell disease frequently experience anemia, or a low number of RBCs. RBCs are responsible for carrying oxygen to the brain and other body tissues that need oxygen to function properly. The purpose of this study is to determine what changes, which were possibly caused by anemia, exist in the brains of individuals with sickle cell disease.
Condition |
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Sickle Cell Disease |
Study Type: | Observational |
Study Design: | Screening, Cross-Sectional, Case Control, Retrospective/Prospective Study |
Official Title: | Sickle-Cell Disease: Neuroimaging and Cognitive Decline |
Estimated Enrollment: | 120 |
Study Start Date: | July 2006 |
The role of RBCs is to carry oxygen from the lungs to the brain and other body tissues. Individuals with anemia have unusually low numbers of RBCs. They also often have difficulty concentrating and remembering information, which is likely caused by a reduced oxygen supply to the brain. Previous research has shown that correcting anemia in patients without sickle cell disease improved their memory and attention. The purpose of this study is to examine any abnormal changes in the brains of individuals with sickle cell disease and to determine whether these changes are related to reduced memory and attention capabilities.
Participants will attend one study visit. During this visit, a brain magnetic resonance image (MRI) will be performed while participants complete neuropsychological tests that measure memory, attention, and organizational ability. There will be no follow-up visits.
Ages Eligible for Study: | 21 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Randall R. Rule, PhD | 415-221-4810 ext 4830 | randall.rule@ucsf.edu |
Contact: Jeffrey Kasten | 415-221-4810 ext 2030 | jeffrey.kasten@ucsf.edu |
United States, California | |
University of California San Francisco | Recruiting |
San Francisco, California, United States, 94121 | |
Contact: Randall R. Rule, PhD 415-221-4810 ext 4830 randall.rule@ucsf.edu | |
Contact: Jeffrey Kasten 415-221-4810 ext 2030 jeffrey.kasten@ucsf.edu | |
Principal Investigator: Randall R. Rule, PhD |
Principal Investigator: | Randall R. Rule, PhD | University of California, San Francisco |
Study ID Numbers: | 375, K01 HL073152 |
Study First Received: | March 23, 2007 |
Last Updated: | April 3, 2007 |
ClinicalTrials.gov Identifier: | NCT00451919 |
Health Authority: | United States: Federal Government |
MRI Neuropsychology |
Anemia, Hemolytic, Congenital Genetic Diseases, Inborn Hematologic Diseases Hemoglobinopathies Anemia |
Anemia, Hemolytic Hemoglobinopathy Anemia, Sickle Cell Sickle cell anemia |