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Sponsors and Collaborators: |
Dutch Heart Foundation Academisch Ziekenhuis Maastricht |
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Information provided by: | Dutch Heart Foundation |
ClinicalTrials.gov Identifier: | NCT00451529 |
Patients with a moderate to severe carotid atherosclerotic plaque are at risk for stroke and this risk increases with increasing degree of stenosis. It has been shown that carotid endarterectomy in symptomatic patients with a carotid artery stenosis of 70-99% is highly beneficial. However, the beneficial effect of surgery in patients with symptomatic 30-69% stenosis is not clear yet.A clear beneficial effect of surgery in the 30-69% stenosis group might be found in a sub-group of patients whom are at greater risk for stroke. Definition of this sub-group might be achieved by plaque characterization, since rupture of a vulnerable plaque is the main cause of stroke due to carotid artery stenosis.This study will include patients with a 30-69% carotid artery stenosis, and assess plaque composition by MRI, the degree of plaque inflammation by FDG-PET, and the amount of microembolization by transcranial Doppler ultrasound. The main purpose of this study is to assess whether one or a combination of each of these imaging methods can predict the occurrence of a (recurrent) ischemic stroke.
Condition |
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Carotid Artery Stenosis |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Predictive Value of Magnetic Resonance Imaging (MRI), 18-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET), and Microemboli Detection for Stroke |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Patients with a history of transient ischemic attack or minor stroke within three months of enrollment and an ipsilateral 30-69% carotid stenosis.
Inclusion Criteria:
Exclusion Criteria:
Contact: Marianne E Kooi, PhD | +31-(0)43-3876910 | eline.kooi@mumc.nl |
Netherlands, Limburg | |
University Hospital Maastricht, Department of Radiology | Recruiting |
Maastricht, Limburg, Netherlands, 6202 AZ | |
Contact: Marianne E Kooi, PhD +31-(0)43-3876910 eline.kooi@mumc.nl |
Principal Investigator: | Marianne E Kooi, PhD | University Hospital Maastricht, Department of Radiology |
Responsible Party: | Dr. M.E. Kooi ( Dr. M.E. Kooi ) |
Study ID Numbers: | 2006 B0 |
Study First Received: | March 22, 2007 |
Last Updated: | November 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00451529 |
Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
Arterial Occlusive Diseases Carotid Stenosis Cerebral Infarction Stroke Vascular Diseases |
Central Nervous System Diseases Constriction, Pathologic Brain Diseases Carotid Artery Diseases Cerebrovascular Disorders |
Nervous System Diseases Cardiovascular Diseases |