Inclusion Criteria:

Patients must meet all of the following criteria to be considered for enrolment:

• Women with newly diagnosed, histologically proven EOC are potentially eligible. Patients with primary peritoneal or fallopian tube tumours of equivalent histology are also considered for enrolment. If open or true cut biopsy is not available, fine needle aspiration (FNA) showing an adenocarcinoma is considered diagnostic for EOC if all 4 (a to d) of the following conditions are satisfied:

  1. Patient has a pelvic mass, AND
  2. Any evidence of disease larger than 1 cm in the upper abdomen (unless proven stage IV), AND
  3. Normal mammography within 6 weeks of randomization, AND
  4. Serum CA-125/CEA greater than or equal to 25. If the ratio is less than 25, a barium enema (or colonoscopy) and gastroscopy (or radiological examination of the stomach) must be negative for a primary tumour.
• Between the ages of 18 and 75.
• FIGO stage IIB to IV disease.
• A pre-study CA-125 level at least twice the upper limit of normal.

• Eligible for standard adjuvant treatment with taxane- and platinum-based chemotherapy by meeting all of the following laboratory findings within 7 days prior to randomization:

  1. Absolute granulocyte count of at least 1.5 x 10 9/L (1500 per cubic millimetre).
  2. Platelet count of at least 150 x 109/L (100,000 per cubic millimetre).
  3. Serum creatinine no greater than 177 micromol/L (2.0 mg/dL).
  4. Total bilirubin level no greater than 1.5 times the upper limit of normal at the local centre.
  5. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels no greater than 3 times the upper limit of normal of the local centre.

Exclusion Criteria:

• Borderline ovarian tumours.
• Received prior chemotherapy or radiation therapy for EOC.
• Received mouse antibodies anytime during the 28 days prior to the pre-study CA-125 level.
• History of another malignancy, unless disease-free for 5 years or greater; non-melanomatous skin carcinoma or curatively treated carcinoma-in-situ of the cervix are excepted.
• Eastern Cooperative Oncology Group (ECOG) performance score of 3 or 4.
• Life expectancy less than 12 weeks.
• Complete bowel obstruction at the time of study enrolment.
• Receiving long-term anticoagulant therapy for an established indication (e.g., atrial fibrillation, mechanical heart valves).
• Bleeding diathesis (e.g., evidence of DIC, hereditary or acquired bleeding disorder).
• History of allergy to any heparin (e.g., heparin-induced thrombocytopenia).
• Significant cardiac history including myocardial infarction within preceding 6 months, congestive heart failure, clinically relevant atrial or ventricular arrhythmias, history of 2nd or 3rd degree heart blocks unless pacemaker is implanted.

• Serious medical conditions that preclude the administration of chemotherapy, anticoagulant therapy, or adherence to protocol, including but not exclusive to:

  1. Allergic reactions to drugs containing cremophor or compounds chemically related to taxanes or platinum analogues.
  2. Significant neurologic or psychiatric disorder that would impair obtaining informed consent and reliable follow-up.
  3. Uncontrolled hypertension despite optimal medical therapy.
  4. Active, uncontrolled infection.
• Women who are pregnant or lactating or are of childbearing potential but are not using effective contraception.
• Total body weight of less than 40 kg.
• Concurrent treatment with experimental or investigational drugs.
• Unable or unwilling to attend scheduled follow-ups.
• Unable (e.g., language barrier, mental illness) to provide informed consent.