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Sponsored by: |
Children's Healthcare of Atlanta |
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Information provided by: | Children's Healthcare of Atlanta |
ClinicalTrials.gov Identifier: | NCT00238810 |
The purpose of this study is to assess brain natriuretic peptide levels to evaluate the relationship of those levels with the diagnosis of congenital cardiac disease, operation performed, post-operative course, and outcome.
Condition |
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Congenital Heart Disease |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal, Defined Population, Retrospective Study |
Official Title: | Retrospective Evaluation of Serum B-Type Natriuretic Peptide Hormone Levels in Post-Operative Patients and the Relationship of BNP Levels to Cardiac Diagnosis, Operation Performed, Post-Operative Course and Outcome |
Study Start Date: | April 2005 |
Three types of natriuretic peptides (NP) have been isolated: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). The NP family elicits a number of vascular, renal and endocrine effects that help to maintain blood pressure and extracellular fluid volume. These effects are mediated by the specific binding of NP to cell surface receptors that have been characterized, purified and cloned from cells of the vasculature, kidney, adrenal gland and brain. There are 3 subtypes of NP receptors: type A natriuretic peptide receptor (NPRA), type B natriuretic peptide receptor (NPRB), and type C natriuretic peptide receptor (NPRC). All 3 subtypes affect cellular second messenger activity. The literature currently does not define the levels of b-type natriuretic peptide (BNP) in children with congenital heart disease undergoing surgery.
The investigator wishes to perform a retrospective chart review to define BNP levels in the pediatric cardiac defect population and to evaluate the relationship of those levels with cardiac diagnosis, operation performed, post-operative course and outcome. The investigator will collect the following information from the medical record:
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
United States, Georgia | |
Children's Healthcare of Atlanta | |
Atlanta, Georgia, United States, 30322 |
Principal Investigator: | Alecia Wang, MD | Emory University Cardiac Fellow at Children's Healthcare of Atlanta |
Study ID Numbers: | 05.068 |
Study First Received: | October 12, 2005 |
Last Updated: | June 12, 2007 |
ClinicalTrials.gov Identifier: | NCT00238810 |
Health Authority: | United States: Institutional Review Board |
BNP Pediatrics Congenital heart disease b-type natriuretic peptide |
Natriuretic Peptide, Brain Heart Diseases Cardiovascular Abnormalities Congenital Abnormalities Heart Defects, Congenital |
Natriuretic Agents Therapeutic Uses Physiological Effects of Drugs |
Cardiovascular Diseases Cardiovascular Agents Pharmacologic Actions |