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HLA Matching - Unrelated Umbilical Cord Blood Transplantation
This study has been completed.
Sponsored by: Children's Memorial Hospital
Information provided by: Children's Memorial Hospital
ClinicalTrials.gov Identifier: NCT00179946
  Purpose

The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation.


Condition Intervention
Hematologic Diseases
 Procedure: HLA typing

U.S. FDA Resources
Study Type: Observational
Study Design: Prospective
Official Title: Impact of HLA Matching on Outcome in Pediatric Patients Undergoing Unrelated Umbilical Cord Blood Transplantation.

Further study details as provided by Children's Memorial Hospital:

Estimated Enrollment: 30
Study Start Date: June 2003
Study Completion Date: April 2006
Primary Completion Date: April 2006 (Final data collection date for primary outcome measure)
Detailed Description:

The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation.

The study will answer the following questions:

  1. Is HLA matching beneficial to unrelated UCB transplantation?
  2. Which HLA loci, HLA-A, B, C, DRB1, or BQB1 is/are important to math, or alternatively to mismatch, to improve graft survival?
  3. Which HLA loci, HLA-A, B, C, DRB1, or BQB1 mismatches is/are "permissive mismatches" or well tolerated mismatches?
  4. What level of typing resolution (low, intermediate, or hgh) is required to perform patient/donor H:A matching?

By studying the cells and blood of donors and recipients, we may learn more about improving the tissue matching between unrelated donors and their recipients. Also, we hope to learn if an additional level of matching testing improves the results of the transplant treatment. Increasing knowledge about tissue matching could result in the improved long-term survival of cord blood transplant recipients.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Pediatric Patients undergoing an unrelated umbilical cord blood transplantation.

Exclusion Criteria:

  • Refusal to participate in study.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00179946

Locations
United States, Illinois
Children's Memorial Hospital
Chicago, Illinois, United States, 60622
Sponsors and Collaborators
Children's Memorial Hospital
Investigators
Principal Investigator: Susanna Rodriguez-Marino, M.D. Children's Memorial Hospital
  More Information

Study ID Numbers: BMT 0603 HLA
Study First Received: September 12, 2005
Last Updated: January 14, 2008
ClinicalTrials.gov Identifier: NCT00179946  
Health Authority: United States: Institutional Review Board

Study placed in the following topic categories:
Hematologic Diseases

ClinicalTrials.gov processed this record on January 14, 2009



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