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| Sponsored by: |
The University of Texas Health Science Center, Houston |
|---|---|
| Information provided by: | The University of Texas Health Science Center, Houston |
| ClinicalTrials.gov Identifier: | NCT00178607 |
Purpose
To correlate the HLA type and genetic defect with hemophilia A.
| Condition |
|---|
|
Hemophilia A |
| Study Type: | Observational |
| Study Design: | Case-Only, Prospective |
| Official Title: | Covalent Tolerance Induction to Factor VIII-Prediction of Inhibitors in Hemophilia |
Serum and Plasma
| Estimated Enrollment: | 150 |
| Study Start Date: | August 2002 |
| Estimated Study Completion Date: | July 2009 |
One of the most serious complications of treatment in patients with hemophilia A or hemophilia B is the development of an inhibitor, which is an antibody that neutralizes the factor VIII or IX coagulant activity. Up to one fourth of patients with severe hemophilia A develop an inhibitor but at present it is not possible to predict which patients will develop such antibody. The ability to predict an inhibitor development at an individual level would greatly improve therapeutic approach to this serious problem
Eligibility| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Subjects with Severe Hemophilia A and a positive inhibitor
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Madeline Cantini, BSN | 713-500-8377 | Madeline.Cantini@uth.tmc.edu |
| United States, Texas | |
| The Univeristy of Texas Health Science Center at Houston | Recruiting |
| Houston, Texas, United States, 77030 | |
| Contact: Madeline Cantini, BSN 713-500-8377 madeline.cantini@uth.tmc.edu | |
| Principal Investigator: Miguel Escobar, MD | |
| Principal Investigator: | Miguel Escobar, MD | The University of Texas Health Science Center, Houston |
More Information
| Responsible Party: | The University of Texas Health Science Center at Houston ( Miguel Escobar MD ) |
| Study ID Numbers: | Inhibitors |
| Study First Received: | September 12, 2005 |
| Last Updated: | January 5, 2009 |
| ClinicalTrials.gov Identifier: | NCT00178607 |
| Health Authority: | United States: Institutional Review Board |
|
Inhibitors |
|
Hemorrhagic Disorders Genetic Diseases, Inborn Hematologic Diseases Blood Coagulation Disorders |
Hemophilia A Hemostatic Disorders Factor VIII |
|
Blood Coagulation Disorders, Inherited Coagulants Coagulation Protein Disorders |
Therapeutic Uses Hematologic Agents Pharmacologic Actions |
