Inclusion Criteria:

• Histologically documented classical Hodgkin lymphoma that is recurrent or refractory to standard chemotherapy.
• Patients must have relapsed or progressed after at least one prior systemic cytotoxic chemotherapy; prior autologous or allogeneic stem cell transplantation is allowed.
• Measurable disease must be present either on physical examination or imaging studies (CT, MRI, PET/CT). Any tumor mass greater or equal to 1 cm is acceptable.
• Age > 18 years old.
• ECOG performance status of less than or equal to 2 at study entry (see Appendix 1).

• Adequate hematologic, renal, hepatic function as defined by:

  • Absolute neutrophil count greater than or equal to 1000 / uL
  • Platelets greater than or equal to 50,000 / uL
  • Serum creatinine less than or equal to 1.5X institution upper limit of normal (ULN)
  • Total bilirubin less than or equal to 2.0 mg/dL
  • AST (SGOT) and ALT (SGPT) less than or equal to 3 x ULN (if not attributed to cHL)
• Disease free of prior malignancies for greater than or equal to 5 years with exception of currently treated basal cell, squamous cell carcinoma of the skin, or carcinoma "in situ" of the cervix or breast.
• Able to adhere to the study visit schedule and other protocol requirements
• Females of childbearing potential (FCBP)† must agree to use two reliable forms of contraception simultaneously or to practice complete abstinence from heterosexual intercourse.
• FCBP must have two negative pregnancy tests (sensitivity of at least 50 mIU/mL) prior to starting study drug.
• Men must agree to use a latex condom during sexual contact with females of childbearing potential while participating in the study and for at least 28 days following discontinuation from the study even if he has undergone a successful vasectomy.
• All patients must be counseled at a minimum of every 28 days about pregnancy precautions and risks of fetal exposure.
• Able to take aspirin (81 or 325 mg) daily as prophylactic anticoagulation (patients intolerant to ASA may use warfarin or low molecular weight

Exclusion Criteria:

• Patients who are candidates for high dose chemotherapy and stem cell transplantation and have not yet undergone stem cell transplantation should not be enrolled.
• Any serious medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from signing the informed consent form.
• Any condition, including the presence of laboratory abnormalities.
• Use of any other anti-cancer drug or therapy, including experimental, within 30 days of enrollment.
• Known hypersensitivity to thalidomide.
• The development of erythema nodosum if characterized by a desquamating rash while taking thalidomide or similar drugs.
• Any prior use of lenalidomide.
• Known positive for HIV or infectious hepatitis, type A, B or C.
• Pregnant or breastfeeding females.
• Concurrent use of other anti-cancer agents or treatments.