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Up-and-Down Procedure (UDP)
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Consumer Product Safety Commission (CPSC)

  • U.S. Code of Federal Regulations (CFR):
    • 16 CFR 1500 - Hazardous Substances and Articles; Administration and Enforcement Regulations
      • 16 CFR 1500.3 - Definitions (includes definitions for "hazardous substances", "toxic", etc.) [PDF]

U.S. Department of Transportation (DOT) Regulations

  • U.S. Code of Federal Regulations (CFR):
    • 49 CFR 172.101 - Hazardous Materials Table [PDF]
    • 49 CFR 173.132 - General Requirements for Shipments and Packagings: Class 6 Definitions (criteria for determining classifications of toxic materials) [PDF]
    • 49 CFR 173.133 - General Requirements for Shipments and Packagings: Assignment of packing group and hazard zones for Division 6.1 materials (poisons) [PDF]

    • U.S. Environmental Protection Agency

    • Office of Prevention, Pesticides and Toxic Substances (OPPTS) Health Effects Test Guidelines, OPPTS 870.1100: Acute Oral Toxicity (December 2002) [PDF]
    • Regulations:
      • 40 CFR 152 - Pesticide Registration and Classification Procedures [PDF]
      • 40 CFR 156 - Labeling Requirements for Pesticides and Devices (includes toxicity categories) [PDF]
      • 40 CFR 158 - Data Requirements for Registration [PDF]
      • 40 CFR 721 - Significant New Uses of Chemical Substances [PDF]

    Organisation for Economic Co-operation and Development (OECD)

    • OECD Series on Testing and Assessment Number 19: Guidance Document on the Recognition, Assessment, and Use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluation (Dec. 20, 2000) [PDF]
    • OECD Series on Testing and Assessment Number 24: Guidance Document on Acute Oral Toxicity Testing (Jul. 23, 2001) [PDF]
    • OECD Guideline for the Testing of Chemicals Number 420: Acute Oral Toxicity - Fixed Dose Method (December 17, 2001) [PDF]
    • OECD Guideline for the Testing of Chemicals Number 423: Acute Oral Toxicity - Acute Toxic Class Method (Dec. 17, 2001) [PDF]
    • OECD Guideline for the Testing of Chemicals Number 425: Acute Oral Toxicity - Up-And-Down Procedure (Mar. 23, 2006) [PDF]
    • (OECD Test Guideline 401: Acute Oral Toxicity has been deleted)

    United Nations

    • Globally Harmonized System of Classification and Labelling of Chemicals (GHS), First Revised Edition, 2005 [PDF]
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