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Sponsors and Collaborators: |
University Hospital, Strasbourg, France Institut National de la Santé Et de la Recherche Médicale, France France: Centre National de la Recherche Scientifique Région Alsace Faculté de Médecine de Strasbourg |
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Information provided by: | University Hospital, Strasbourg, France |
ClinicalTrials.gov Identifier: | NCT00350935 |
The main objective of the study is to contribute to a better understanding of the physiopathology of schizophrenia, by studying causal relationships between cognitive deficits and the neurobiological basis for these deficits. Processing visual information involves both automatic grouping processes and control processes. Automatic grouping processes allow the building of a global configuration from local contour information. It is necessary in order to recognize objects. Control processes allow tending to and prioritizing information parts. The paradigm the investigators use allows to dissociate these processes, and is used in order to characterize the impairments observed in patients with schizophrenia. It is adapted to fMRI in order to explore the neurobiological basis of the deficits. The investigators will examine whether functional disconnectivity between activated areas subtend the impairments observed in patients.
Condition | Intervention |
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Schizophrenia |
Procedure: fMRI |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Attention and Grouping of Visual Information: What is Disturbed in Patients With Schizophrenia? |
Estimated Enrollment: | 52 |
Study Start Date: | September 2006 |
Estimated Study Completion Date: | December 2008 |
Groups/Cohorts | Assigned Interventions |
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Healthy volunteers
Healthy controls
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Procedure: fMRI
One 30 minute session
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Patients
Patients with schizophrenia
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Procedure: fMRI
One 30 minute session
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Ages Eligible for Study: | 18 Years to 50 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Primary care clinic, residents of Strasbourg
Inclusion Criteria:
Exclusion Criteria:
France | |
Inserm U666 - Département de Psychiatrie, Hôpitaux Universitaires de Strasbourg | |
Strasbourg, France, 67091 |
Principal Investigator: | Anne Giersch, MD | Institut National de la Santé Et de la Recherche Médicale, France |
Responsible Party: | University Hospital, Strasbourg, France ( Emmanuel LAVOUE, Directeur Adjoint de la DRCI ) |
Study ID Numbers: | 3456 |
Study First Received: | July 10, 2006 |
Last Updated: | October 10, 2008 |
ClinicalTrials.gov Identifier: | NCT00350935 |
Health Authority: | France: Ministry of Health |
fMRI Visual perception Attention |
Schizophrenia Mental Disorders Psychotic Disorders Schizophrenia and Disorders with Psychotic Features |