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Attention and Visual Perception in Schizophrenia: A Functional Magnetic Resonance Imaging (fMRI) Study
This study is ongoing, but not recruiting participants.
Sponsors and Collaborators: University Hospital, Strasbourg, France
Institut National de la Santé Et de la Recherche Médicale, France
France: Centre National de la Recherche Scientifique
Région Alsace
Faculté de Médecine de Strasbourg
Information provided by: University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier: NCT00350935
  Purpose

The main objective of the study is to contribute to a better understanding of the physiopathology of schizophrenia, by studying causal relationships between cognitive deficits and the neurobiological basis for these deficits. Processing visual information involves both automatic grouping processes and control processes. Automatic grouping processes allow the building of a global configuration from local contour information. It is necessary in order to recognize objects. Control processes allow tending to and prioritizing information parts. The paradigm the investigators use allows to dissociate these processes, and is used in order to characterize the impairments observed in patients with schizophrenia. It is adapted to fMRI in order to explore the neurobiological basis of the deficits. The investigators will examine whether functional disconnectivity between activated areas subtend the impairments observed in patients.


Condition Intervention
Schizophrenia
Procedure: fMRI

MedlinePlus related topics: MRI Scans Schizophrenia
U.S. FDA Resources
Study Type: Observational
Study Design: Case Control, Prospective
Official Title: Attention and Grouping of Visual Information: What is Disturbed in Patients With Schizophrenia?

Further study details as provided by University Hospital, Strasbourg, France:

Biospecimen Retention:   None Retained

Biospecimen Description:

Estimated Enrollment: 52
Study Start Date: September 2006
Estimated Study Completion Date: December 2008
Groups/Cohorts Assigned Interventions
Healthy volunteers
Healthy controls
Procedure: fMRI
One 30 minute session
Patients
Patients with schizophrenia
Procedure: fMRI
One 30 minute session

  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Primary care clinic, residents of Strasbourg

Criteria

Inclusion Criteria:

  • Patients with schizophrenia (DSM-IV criteria)
  • Healthy controls matched with patients on age, sex and education level
  • Ages 18 to 50
  • Signed informed consent
  • Right-handed

Exclusion Criteria:

  • No severe somatic illness
  • No invalidating sensory disease
  • No drug abuse, as defined by DSM-IV criteria
  • No general anaesthesia in the past 3 months
  • No intake of drugs affecting the CNS, except for patients
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00350935

Locations
France
Inserm U666 - Département de Psychiatrie, Hôpitaux Universitaires de Strasbourg
Strasbourg, France, 67091
Sponsors and Collaborators
University Hospital, Strasbourg, France
Institut National de la Santé Et de la Recherche Médicale, France
France: Centre National de la Recherche Scientifique
Région Alsace
Faculté de Médecine de Strasbourg
Investigators
Principal Investigator: Anne Giersch, MD Institut National de la Santé Et de la Recherche Médicale, France
  More Information

Responsible Party: University Hospital, Strasbourg, France ( Emmanuel LAVOUE, Directeur Adjoint de la DRCI )
Study ID Numbers: 3456
Study First Received: July 10, 2006
Last Updated: October 10, 2008
ClinicalTrials.gov Identifier: NCT00350935  
Health Authority: France: Ministry of Health

Keywords provided by University Hospital, Strasbourg, France:
fMRI
Visual perception
Attention

Study placed in the following topic categories:
Schizophrenia
Mental Disorders
Psychotic Disorders
Schizophrenia and Disorders with Psychotic Features

ClinicalTrials.gov processed this record on January 14, 2009