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Sponsors and Collaborators: |
University Hospital, Strasbourg, France Institut National de la Santé Et de la Recherche Médicale, France France: Centre National de la Recherche Scientifique Faculté de Médecine de Strasbourg |
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Information provided by: | University Hospital, Strasbourg, France |
ClinicalTrials.gov Identifier: | NCT00350805 |
Abnormalities in the ability to distinguish events in time may have a great impact on everyday life. The main objective of the study is to evaluate the magnitude of the temporal windows in schizophrenia, i.e. the time interval during which two events are perceived as synchronous. The investigators test the hypothesis that these temporal windows are enlarged, and check the relationship between this impairment and disorganization symptoms, in order to explore the link between this cognitive impairment and clinical symptoms. They explore also the neurobiological bases of the impairment by means of electroencephalogram (EEG) recordings. Event-related potentials (N50) will reveal whether or not the coding of the stimuli has the same temporal characteristics in patients and controls. The distribution and amplitude of oscillatory activities will be analyzed as a function of the synchronous or asynchronous response of the subject, thus allowing to explore the links between synchrony perception and neuronal synchronization phenomena.
Condition | Intervention |
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Schizophrenia |
Procedure: EEG |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Relating the 'Experienced Present' With the Mechanisms of Neuronal Function: A Comparative Study in Patients With Schizophrenia and Healthy Controls Using Psychophysical and Neurophysiological Methods |
Estimated Enrollment: | 228 |
Study Start Date: | September 2005 |
Estimated Study Completion Date: | December 2009 |
Groups/Cohorts | Assigned Interventions |
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Healthy volunteers |
Procedure: EEG
One 20 minutes session
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Patients |
Procedure: EEG
One 20 minutes session
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Ages Eligible for Study: | 18 Years to 50 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Primary care clinic, residents of Strasbourg
Inclusion Criteria:
Contact: Anne GIERSCH, MD | 33.3.88.11.64.71 | giersch@alsace.u-strasbg.fr |
France | |
INSERM U666 - Département de Psychiatrie - Hôpitaux Universitaires de Strasbourg | Recruiting |
Strasbourg, France, 67091 | |
Contact: Anne GIERSCH, MD 33.3.88.11.64.71 giersch@alsace.u-strasbg.fr | |
Principal Investigator: Anne GIERSCH, MD | |
Sub-Investigator: Pierre VIDAILHET, MD | |
Sub-Investigator: Philippe SONNTAG, MD | |
Sub-Investigator: Marie-Agathe ZIMMERMANN, MD | |
Sub-Investigator: Daniel GRUCKER, MD | |
Sub-Investigator: Jack FOUCHER, MD | |
Service de Psychiatrie Adulte & INSERM U841, Hôpital Albert Chenevier et Henri Mondor (AP-HP) | Recruiting |
Créteil, France, 94000 | |
Contact: Franck SCHURHOFF, MD 33.3.1.49.81.30.50 schurhof@ext.jussieu.fr | |
Principal Investigator: Franck SCHURHOFF, MD | |
Sub-Investigator: Andrei SZOKE, MD |
Principal Investigator: | Anne GIERSCH, MD | Institut National de la Santé Et de la Recherche Médicale, France |
Responsible Party: | University Hospital, Strasbourg, France ( Emmanuel LAVOUE, Directeur Adjoint de la DRCI ) |
Study ID Numbers: | 3494 |
Study First Received: | July 10, 2006 |
Last Updated: | December 10, 2008 |
ClinicalTrials.gov Identifier: | NCT00350805 |
Health Authority: | France: Ministry of Health |
Schizophrenia Time perception Cortical synchronization Electroencephalography |
Schizophrenia Mental Disorders Psychotic Disorders Healthy Schizophrenia and Disorders with Psychotic Features |