Split-Thickness Skin Graft Donor Site Wound Healing Study - Full Text View

Sponsored by:	University of Mississippi Medical Center
Information provided by:	University of Mississippi Medical Center
ClinicalTrials.gov Identifier:	NCT00392301

Purpose

The purpose of this research study is to discover whether instruments widely used in skin research can be used to measure wound healing in split thickness skin graft donor sites and whether these instruments can detect differences in healing when two different dressing products are used.

Condition
Split-Thickness Skin Graft Donor Sites

U.S. FDA Resources

Study Type:	Observational
Study Design:	Prospective
Official Title:	Split-Thickness Skin Graft Donor Site Wound Healing Study

Further study details as provided by University of Mississippi Medical Center:

Biospecimen Retention: None Retained

Biospecimen Description:

Estimated Enrollment:	30
Study Start Date:	April 2007

Detailed Description:

Currently there is no standard treatment to promote wound healing for split thickness skin graft donor sites and healing is determined based on clinical observation of the graft donor site and clinical judgement. Here we propose to use two instruments commonly used in skin research to measure wound healing. This study will validate the use of these two instruments, one that measures transepidermal water loss and the other that measures skin pigmentation to determine healing. To further validate the use of these instruments we will determine if these instruments can detect differences between two different wound dressing products that have been previously reported to heal skin graft donor sites at different rates.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Subjects with split thickness skin graft donor sites

Criteria

Inclusion Criteria:

Participants 18 years of age and over who have a split-thickness skin graft donor site.

Exclusion Criteria:

Individuals under 18 years of age.
Individuals who do not have a split thickness skin graft donor site.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00392301

Contacts

Contact: Annette B. Wysocki, PhD, RN	601-815-4267	awysocki@son.umsmed.edu
Contact: Barbara Rogers, PhD, RN	601-984-6233	brogers@son.umsmed.edu

Locations

United States, Mississippi
University of Mississippi Medical Center	Recruiting
Jackson, Mississippi, United States, 39216
Contact: Annette B. Wysocki, PhD, RN 601-815-4267 awysocki@son.umsmed.edu
Sub-Investigator: Gayle Harrell, MSN, NP
Sub-Investigator: Barbara P Rogers, PhD, RN

Sponsors and Collaborators

University of Mississippi Medical Center

Investigators

Principal Investigator:

Annette B. Wysocki, PhD, RN

University of Mississippi Medical Center

More Information

Publications:

Disa JJ, Alizadeh K, Smith JW, Hu Q, Cordeiro PG. Evaluation of a combined calcium sodium alginate and bio-occlusive membrane dressing in the management of split-thickness skin graft donor sites. Ann Plast Surg. 2001 Apr;46(4):405-8.

Feldman DL, Rogers A, Karpinski RH. A prospective trial comparing Biobrane, Duoderm and xeroform for skin graft donor sites. Surg Gynecol Obstet. 1991 Jul;173(1):1-5.

Feldman DL. Which dressing for split-thickness skin graft donor sites? Ann Plast Surg. 1991 Sep;27(3):288-91. Review.

Kilinc H, Sensoz O, Ozdemir R, Unlu RE, Baran C. Which dressing for split-thickness skin graft donor sites? Ann Plast Surg. 2001 Apr;46(4):409-14.

Malpass KG, Snelling CF, Tron V. Comparison of donor-site healing under Xeroform and Jelonet dressings: unexpected findings. Plast Reconstr Surg. 2003 Aug;112(2):430-9.

Rakel BA, Bermel MA, Abbott LI, Baumler SK, Burger MR, Dawson CJ, Heinle JA, Ocheltree IM. Split-thickness skin graft donor site care: a quantitative synthesis of the research. Appl Nurs Res. 1998 Nov;11(4):174-82. Review.

Responsible Party:	University of Mississippi Medical Center ( Annette Wysocki, PhD, RN )
Study ID Numbers:	2006-0094
Study First Received:	October 23, 2006
Last Updated:	October 8, 2008
ClinicalTrials.gov Identifier:	NCT00392301
Health Authority:	United States: Institutional Review Board

Keywords provided by University of Mississippi Medical Center:

wound healing
skin
graft donor site
donor site
transepidermal water loss

ClinicalTrials.gov processed this record on January 14, 2009