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Sponsored by: |
Glaxo Wellcome |
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Information provided by: | NIH AIDS Clinical Trials Information Service |
ClinicalTrials.gov Identifier: | NCT00002284 |
To determine whether zidovudine (AZT) in conjunction with bone marrow transplantation prevents the reinfection of donor hematopoietic/lymphoid cells in patients with positive HTLV III antibody and large cell/diffuse histiocytic lymphoma. Patients who are candidates will be evaluated for HTLV III activity and drug levels.
Condition | Intervention |
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Lymphoma, Non-Hodgkin HIV Infections |
Drug: Zidovudine |
Study Type: | Interventional |
Study Design: | Treatment, Dose Comparison |
Official Title: | A Pilot Study To Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients Receiving a Bone Marrow Transplant |
Ages Eligible for Study: | 12 Years to 50 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Exclusion Criteria
Co-existing Condition:
Patients with current life-threatening infection at time of transplant that would preclude a transplant are excluded.
Concurrent Medication:
Excluded:
Patients with current life-threatening infection at time of transplant that would preclude a transplant are excluded.
Patients must be:
Study ID Numbers: | 014A, 006 |
Study First Received: | November 2, 1999 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00002284 |
Health Authority: | United States: Food and Drug Administration |
Lymphoma, Large-Cell Acquired Immunodeficiency Syndrome AIDS-Related Complex Zidovudine Bone Marrow Transplantation |
Sexually Transmitted Diseases, Viral Immunoproliferative Disorders Acquired Immunodeficiency Syndrome Zidovudine AIDS-Related Complex Immunologic Deficiency Syndromes Lymphoma, large-cell Virus Diseases |
Lymphatic Diseases HIV Infections Sexually Transmitted Diseases Lymphoma, Non-Hodgkin Lymphoproliferative Disorders Lymphoma Retroviridae Infections |
Antimetabolites Anti-Infective Agents Communicable Diseases RNA Virus Infections Anti-HIV Agents Slow Virus Diseases Neoplasms by Histologic Type Immune System Diseases Molecular Mechanisms of Pharmacological Action Enzyme Inhibitors |
Infection Antiviral Agents Pharmacologic Actions Reverse Transcriptase Inhibitors Neoplasms Anti-Retroviral Agents Therapeutic Uses Lentivirus Infections Nucleic Acid Synthesis Inhibitors |