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| Sponsored by: |
University of Pittsburgh |
|---|---|
| Information provided by: | NIH AIDS Clinical Trials Information Service |
| ClinicalTrials.gov Identifier: | NCT00002276 |
Purpose
To determine if platelet dysfunction and/or pharmacologic drug interaction occurs in patients taking both AZT and ibuprofen, which might account for enhanced bleeding tendency.
| Condition | Intervention |
|---|---|
|
HIV Infections Hemophilia A |
Drug: Ibuprofen Drug: Zidovudine |
| Study Type: | Interventional |
| Study Design: | Treatment |
| Official Title: | Study of Bleeding Tendency, Platelet Function, and Pharmacokinetics of Azidothymidine (AZT) and Motrin (Ibuprofen) in HIV-Infected Hemophiliacs |
Eligibility| Ages Eligible for Study: | 12 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria
Patients must have:
Prior Medication:
Required:
- AZT for study patients.
Allowed:
- Ibuprofen.
Exclusion Criteria
Co-existing Condition:
Patients with the following symptoms and conditions are excluded:
Hospitalization for opportunistic infection, bacterial infection or malignancy.
Concurrent Medication:
Excluded:
Patients with the following prior conditions are excluded:
Hospitalization for opportunistic infection, bacterial infection, or malignancy.
Required:
Contacts and Locations More Information
| Study ID Numbers: | 044A |
| Study First Received: | November 2, 1999 |
| Last Updated: | June 23, 2005 |
| ClinicalTrials.gov Identifier: | NCT00002276 |
| Health Authority: | United States: Food and Drug Administration |
|
Blood Platelets Ibuprofen Drug Interactions Zidovudine Hemophilia A |
|
Ibuprofen Sexually Transmitted Diseases, Viral Hematologic Diseases Blood Coagulation Disorders Acquired Immunodeficiency Syndrome Hemophilia A Zidovudine Hemorrhage |
Hemostatic Disorders Immunologic Deficiency Syndromes Virus Diseases Hemorrhagic Disorders Genetic Diseases, Inborn HIV Infections Sexually Transmitted Diseases Retroviridae Infections |
|
Anti-Inflammatory Agents Antimetabolites Anti-Infective Agents Slow Virus Diseases Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Infection Reverse Transcriptase Inhibitors Anti-Retroviral Agents Sensory System Agents Therapeutic Uses Anti-Inflammatory Agents, Non-Steroidal Analgesics Nucleic Acid Synthesis Inhibitors |
RNA Virus Infections Anti-HIV Agents Immune System Diseases Coagulation Protein Disorders Cyclooxygenase Inhibitors Enzyme Inhibitors Antiviral Agents Pharmacologic Actions Blood Coagulation Disorders, Inherited Analgesics, Non-Narcotic Lentivirus Infections Peripheral Nervous System Agents Antirheumatic Agents Central Nervous System Agents |
