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Sponsored by: |
Hospices Civils de Lyon |
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Information provided by: | Hospices Civils de Lyon |
ClinicalTrials.gov Identifier: | NCT00169637 |
This is a randomized controlled, parallel group, open label versus "no treatment" trial which evaluate the efficacy of rhGH on weaning off parenteral nutrition in children with short bowel syndrome.The total follow-up is 14 months; 4 months for each group after randomization; At the end of the first four months: the treated group will be followed within 6 months, the untreated group will receive compassionately rhGH for 4 months and followed-up for 6 months after the end of the treatment period.
Condition | Intervention | Phase |
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Short Bowel Syndrome |
Drug: rhGH |
Phase III |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Parallel Assignment |
Official Title: | Evaluation of the Efficacy and Safety of Recombinant Human Growth Hormone (rhGH) in the Treatment of Children With Short Bowel Syndrome |
Enrollment: | 14 |
Study Start Date: | June 2006 |
Study Completion Date: | June 2008 |
Ages Eligible for Study: | 3 Years to 18 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Age 3-18 year with a bone age test under 18-year Children with short bowel syndrome and intestinal insufficiency, the remaining bowel length should be under 80 cm after the first post-surgical period.
Parenteral nutrition dependency: under parenteral nutrition for at least 3 years with parenteral glycolipidic diet > or = 30% of the total caloric need for age. The parenteral diet should have been stable for at least 3 months.
Parents consent
Exclusion Criteria:
Over 20% change in caloric daily requirement within the last 6 months before inclusion.
Surgery on digestive tube within the last 3 months. Administration of drugs targeting digestion (decontamination, macrobiotic, gastric dressing, chelating agents of biliary salts) within the last month.
History or presence of tumoral process, leukaemia, minor intracranial hypertension, epiphysiolysis, carpal tunnel syndrome.
Ongoing infection (fever and inflammatory biologic syndrome), progressive inflammatory syndrome.
Heart failure, renal and respiratory insufficiency. Allergy to solvent. Any condition making impossible the follow-up of the patient during the study. Person participating in another clinical trial or taking another medication under investigation within one month before inclusion.
Responsible Party: | Hospices Civils de Lyon ( Alain Lachaux ) |
Study ID Numbers: | 2002.301 |
Study First Received: | September 12, 2005 |
Last Updated: | October 30, 2008 |
ClinicalTrials.gov Identifier: | NCT00169637 |
Health Authority: | France: Afssaps - French Health Products Safety Agency |
Short bowel syndrome Growth hormone Children |
Digestive System Diseases Postoperative Complications Gastrointestinal Diseases |
Malabsorption Syndromes Short Bowel Syndrome Intestinal Diseases |
Disease Pathologic Processes Syndrome |