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Sponsors and Collaborators: |
Radboud University ZonMw: The Netherlands Organisation for Health Research and Development |
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Information provided by: | Radboud University |
ClinicalTrials.gov Identifier: | NCT00141466 |
The purpose of this study is to compare two different strategies to implement a new method to identify patients with HNPCC, which appeared cost-effective and feasible. The effectiveness, costs and feasibility of both of the implementation strategies will be assessed.
Condition | Intervention |
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Colorectal Neoplasms Hereditary Nonpolyposis Colorectal Cancer |
Behavioral: Education for professionals Behavioral: Distribution of educational materials Behavioral: Feedback for professionals Behavioral: Reminders for professionals |
Study Type: | Interventional |
Study Design: | Randomized, Single Blind, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | Cost Effectiveness of Two Different Implementation Procedures to Change Clinicians Practice Roles in the Detection of Hereditary Colorectal Cancer |
Estimated Enrollment: | 360 |
Study Start Date: | September 2005 |
Estimated Study Completion Date: | July 2007 |
The Radboud University Nijmegen Medical Centre developed a new method to identify patients with HNPCC. This method appeared cost-effective and feasible. Using this new method 70% of the HNPCC patients will be identified as compared to less than 30% when the current method is used. However, this new method does not implement itself; large gaps exists between best evidence and daily practice. This study will compare an intensive strategy, consisting of distribution of educational materials, education, feedback and reminders, with a minimal strategy, only consisting of distribution of a critical care pathway. The aim is to find the most cost-effective strategy to implement the new method to identify patients with HNPCC in the Netherlands.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Contact: Lucy I Overbeek, MSc | +31-24-3613946 | l.overbeek@antrg.umcn.nl |
Contact: Nicoline Hoogerbrugge, MD PhD | +31-24-3613946 | n.hoogerbrugge@antrg.umcn.nl |
Netherlands | |
St. Elisabeth Ziekenhuis | Recruiting |
Tilburg, Netherlands | |
Contact: Anneke van der Wurff, MD PhD | |
Laboratorium voor pathologie Oost-Nederland | Recruiting |
Enschede, Netherlands | |
Contact: Sietske Riemersma, MD | |
Elkerliek Ziekenhuis | Recruiting |
Helmond, Netherlands | |
Contact: Cilia M Ferrier, MD PhD | |
Jeroen Bosch Ziekenhuis | Recruiting |
's-Hertogenbosch, Netherlands | |
Contact: Stan J Ketelaars, MD | |
Ziekenhuis Rijnstate | Recruiting |
Arnhem, Netherlands | |
Contact: Jos Meijer, MD | |
Canisius Wilhelmina Ziekenhuis | Recruiting |
Nijmegen, Netherlands | |
Contact: Erik Thunnissen, MD PhD | |
Meander Medisch Centrum | Recruiting |
Amersfoort, Netherlands | |
Contact: Els JM Ahsmann, MD PhD | |
Laboratorium Volksgezondheid Friesland | Recruiting |
Leeuwarden, Netherlands | |
Contact: Joris J Grond, MD PhD | |
Martini Ziekenhuis | Recruiting |
Groningen, Netherlands | |
Contact: Ton Tiebosch, MD PhD | |
Pathologie laboratorium voor Dordrecht | Recruiting |
Dordrecht, Netherlands | |
Contact: Pieter J Westenend, MD PhD | |
HagaZiekenhuis | Recruiting |
Den Haag, Netherlands | |
Contact: Paul Blok, MD PhD | |
Medisch Centrum Rijnmond Zuid | Recruiting |
Rotterdam, Netherlands | |
Contact: Sonja Henzen, MD PhD | |
Stichting laboratoria voor pathologische anatomie en medische microbiologie | Recruiting |
Eindhoven, Netherlands | |
Contact: Ineke van Lijnschoten, MD PhD |
Principal Investigator: | Nicoline Hoogerbrugge, MD PhD | Department of Human Genetics, Radboud University Nijmegen Medical Center |
Principal Investigator: | Rosella P Hermens, MSc PhD | Center of Quality of Care Research, Radboud University Nijmegen Medical Center |
Study ID Numbers: | MIPA-2005, ZonMw nr. 945-14-107 |
Study First Received: | August 31, 2005 |
Last Updated: | April 22, 2008 |
ClinicalTrials.gov Identifier: | NCT00141466 |
Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
Hereditary colorectal cancer Microsatellite instability Physician roles Health care implementation Intervention |
Metabolic Diseases Digestive System Neoplasms Microsatellite Instability Gastrointestinal Diseases Colonic Diseases Hereditary nonpolyposis colon cancer Intestinal Diseases Rectal Diseases Intestinal Neoplasms |
Digestive System Diseases Neoplastic Syndromes, Hereditary Colorectal Neoplasms, Hereditary Nonpolyposis Genetic Diseases, Inborn Colorectal cancer, hereditary nonpolyposis, type 1 Gastrointestinal Neoplasms Metabolic disorder Colorectal Neoplasms |
Neoplasms Neoplasms by Site DNA Repair-Deficiency Disorders |