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Sponsors and Collaborators: |
University of Texas Southwestern Medical Center Donald W. Reynolds Foundation |
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Information provided by: | University of Texas Southwestern Medical Center |
ClinicalTrials.gov Identifier: | NCT00344903 |
The Dallas Heart Study (DHS-1) is a large, multi-ethnic, population-based epidemiological study designed to identify determinants of atherosclerotic heart disease (ASHD) in a representative United States (US) urban environment. This study completed enrollment in 2003.
Our objective is to pinpoint factors contributing to progression:
Identification of the critical factors in these transitions will enable targeted implementation of appropriate therapy to interdict before clinical ASHD develops.
Condition |
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Atherosclerosis Congestive Heart Failure Left Ventricular Hypertrophy Diabetes Mellitus Hypertension Obesity Metabolic Syndrome X Myocardial Infarction |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Longitudinal Cohort Study of Dallas County Residents to Identify Novel Determinants of Atherosclerotic Heart Disease: The DHS 2 |
Estimated Enrollment: | 3000 |
Study Start Date: | September 2007 |
Estimated Study Completion Date: | December 2008 |
Early medical intervention in asymptomatic individuals at risk is the most effective strategy to combat atherosclerotic heart disease (ASHD). The major roadblock to effective ASHD prevention is that conventional tools to assess ASHD risk are inadequate and new methods are needed to identify susceptible individuals before the disease process is established. Other successful public-health screening programs have incorporated direct imaging procedures (e.g. mammography, colonoscopy); yet in ASHD, direct imaging of the vasculature has not been incorporated into the risk stratification algorithms.
The Dallas Heart Study (DHS-1) is a large, multi-ethnic, population-based epidemiological study designed to identify determinants of ASHD in a representative US urban environment. This study completed enrollment in 2003.
In DHS-2 we will transform the Dallas Heart Study from a cross-sectional health survey (DHS-1) into a longitudinal cohort study (DHS-2). We will perform state-of-the-art cardiovascular (CV) imaging coupled to biomarkers, genetic markers and classical ASHD risk factors. We will repeat the detailed clinical phenotyping performed between 2000-2003 to capture interval changes in ASHD risk and disease burden. Our objective is to pinpoint factors contributing to progression:
Identification of the critical factors in these transitions will enable targeted implementation of appropriate therapy to interdict before clinical ASHD develops.
Ages Eligible for Study: | 35 Years to 70 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
Adults who participated in DHS-1. The study will include equal numbers of men and women and will include 50% African Americans
Inclusion Criteria:
Exclusion Criteria:
Contact: Kate Wilikinson, MS | 214-648-1438 | kathleen.wilkinson@utsouthwestern.edu |
Contact: Teresa Eversole, BS | 214-648-1600 | teresa.eversole@utsouthwestern.edu |
United States, Texas | |
UT Southwestern Medical Center | Recruiting |
Dallas, Texas, United States, 75390-9047 |
Study Chair: | Helen Hobbs, MD | UT Southwestern Medical Center |
Responsible Party: | UT Southwestern Medical Center ( Helen Hobbs, MD ) |
Study ID Numbers: | DHS-2-001 |
Study First Received: | June 23, 2006 |
Last Updated: | June 19, 2008 |
ClinicalTrials.gov Identifier: | NCT00344903 |
Health Authority: | United States: Institutional Review Board |
Atherosclerosis Heart Failure Ventricular Hypertrophy Myocardial Infarction Screening |
Hypertension Diabetes Obesity Metabolic Syndrome |
Atherosclerosis Pathological Conditions, Anatomical Myocardial Ischemia Overweight Arteriosclerosis Body Weight Hyperinsulinism Signs and Symptoms Necrosis Syndrome X Nutrition Disorders Myocardial Infarction Abdominal obesity metabolic syndrome Arterial Occlusive Diseases Obesity |
Hypertrophy, Left Ventricular Heart Failure Metabolic Syndrome X Heart Diseases Metabolic Diseases Diabetes Mellitus Vascular Diseases Endocrine System Diseases Ischemia Hypertrophy Overnutrition Endocrinopathy Insulin Resistance Metabolic disorder Infarction |
Disease Pathologic Processes Syndrome Cardiovascular Diseases |