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Colon and Rectal Cancer Home Page
NCI's gateway for information about colon and rectal cancer.

What You Need To Know About Colon & Rectal Cancer
Information about detection, symptoms, diagnosis, and treatment of colon and rectal cancer.
NIH Publication No. 03-1552

Screening and Testing
Colorectal Cancer Screening (PDQ®)
[ patient ] [ health professional ]
Expert-reviewed information summary about tests used to detect or screen for colorectal cancer.

Clinical Trials to Screen for Colon Cancer
Check for colon cancer screening trials from NCI's PDQ® Cancer Clinical Trials Registry now accepting patients. The list of clinical trials can be refined by location, stage of disease, drug, and other features.

Clinical Trials to Screen for Rectal Cancer
Check for rectal cancer screening trials from NCI's PDQ® Cancer Clinical Trials Registry now accepting patients. The list of clinical trials can be refined by location, stage of disease, drug, and other features.

Colorectal Cancer Screening
This fact sheet discusses the advantages and disadvantages of several colorectal cancer screening tests. National Cancer Institute Fact Sheet 5.31

Large, Multi-Center Trial Demonstrates Comparable Accuracy for Virtual Colonoscopy and Standard Colonoscopy
Computerized tomographic colonography, also known as virtual colonoscopy, is comparable to standard colonoscopy, which uses a long, flexible tube with a camera to view the lining of the colon, in its ability to accurately detect cancer and precancerous polyps and could serve as an initial screening exam for colorectal cancer, according to the results of the American College of Radiology Imaging Network National CT Colonography Trial.

Flat and Depressed Colorectal Growths May Change Screening
A study from the Veterans Affairs (VA) Health Care System in Palo Alto, CA, published in the March 5, 2008 Journal of the American Medical Association adds to a growing body of evidence that nonpolypoid colorectal neoplasms (NP-CRNs) - abnormalities that can appear either flat or depressed relative to the surrounding membrane - can also contain precancerous or cancerous cells.

New Fecal Occult Blood Test (FOBT) Promising for Detection of Colon Cancer
A type of fecal occult blood test called a fecal immunochemical test (FIT) showed high sensitivity and specificity for detecting left-sided colorectal cancer in a study published September 25, 2007, by the Journal of the National Cancer Institute.

Colorectal Cancer Research from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial: NCI Fact Sheet
In the PLCO trial, researchers are testing flexible sigmoidoscopy. During a sigmoidoscopy, a thin, lighted viewing instrument is inserted into the rectum to examine the left, or distal, portion of the colorectum.

National Cancer Institute Trial Yields New Data on Colon Cancer Screening Test
New data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial give fresh insight into the appropriate screening intervals for colorectal cancer after a negative exam.

Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
A large-scale clinical trial to determine whether certain cancer screening tests reduce deaths from prostate, lung, colorectal, and ovarian cancer. In addition, there are numerous epidemiologic and ancillary studies going on that will answer other crucial questions about these cancers and these screening tests.

Study Suggests Physicians Overperform Surveillance Colonoscopies
Physicians appear to be performing surveillance colonoscopies at frequencies higher than those recommended by evidence-based medical guidelines, according to results of a survey conducted by the National Cancer Institute (NCI), part of the National Institutes of Health. Questions and Answers

HHS Urges Colorectal Cancer Screening to Save Lives
HHS Secretary Tommy G. Thompson today affirmed the value of colorectal cancer screening and encouraged Americans age 50 or older to get screened.

U.S. Preventive Services Task Force Urges Colorectal Cancer Screening for All Americans 50 and Older
The U.S. Preventive Services Task Force, in its strongest ever recommendation for colorectal cancer screening, today urged that all adults age 50 and over get screened for the disease.

Interpreting Laboratory Test Results
A fact sheet that describes the role of screening and diagnostic laboratory tests. Includes a brief discussion of factors affecting the results. National Cancer Institute Fact Sheet 5.27

Tumor Markers: Questions and Answers
A fact sheet that defines tumor markers and describes how they can be used to aid diagnosis and treatment. National Cancer Institute Fact Sheet 5.18

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