Inclusion Criteria:

• A male or female between and including 18-40 years at the time of first vaccination.
• Written informed consent obtained from the subject prior to any study procedure.
• Subjects who the investigator believes that they can and will comply with the requirements of the protocol.
• Good general health without significant medical history, physical examination findings, or clinically significant abnormal laboratory results.
• If the subject is female, she must be of non-childbearing potential, or if she is of childbearing potential, she must practice adequate contraception for 30 days prior to vaccination, have a negative pregnancy test and continue such precautions for 2 months after completion of the vaccination series.
• Negative for antibodies against HIV-1, HIV-2 and negative for HIV p24 antigen within 56 days (8 weeks) prior to enrolment. Subjects must be willing to accept HIV test results. Individuals who elect not to receive test results will not be enrolled.
• Negative for anti-HBc Ab, HBsAg and anti-HCV Ab.

Exclusion Criteria:

• Women who are pregnant or breast-feeding.
• Subjects with a history of, or current, alcohol or substance abuse.
• The subject is at high risk of acquiring HIV according to the behavioural risk assessment questionnaire.
• Morbid obesity
• Previous inclusion in a HIV vaccines trial.
• Receipt of live attenuated vaccines within 30 days of enrolment.
• Receipt of medically indicated subunit or killed vaccines or allergy treatment with antigen injections within 14 days of study vaccine administration.
• Use of any investigational or non-registered product (drug or vaccine) other than the study vaccines within 30 days preceding the first dose of study vaccine, or planned use during the study period.
• Prior receipt of HIV-1 vaccines or placebo in a previous HIV vaccine trial.
• Receipt of blood products 120 days prior to HIV screening.
• Receipt of immunoglobulin 120 days prior to HIV screening.
• History of serious adverse reactions including anaphylaxis and related symptoms such as hives, respiratory difficulty, angioedema and abdominal pain to vaccines.
• History of serious allergic reaction to any substance requiring hospitalization or emergency medical care.
• History of immunodeficiency or autoimmune disease.
• History of malignancy (unless there has been surgical excision followed by a sufficient observation period, of at least 5 years, to give a reasonable assurance of sustained cure and which, in the estimate of the investigator, is not likely to recur during the study period).
• Chronic administration of immunosuppressants or other immune-modifying drugs within six months prior to the first vaccination.
• History of type I or type II diabetes mellitus including cases controlled with diet alone. A subject with past gestational diabetes is eligible.
• Thyroid disease including history of thyroidectomy and diagnoses requiring medication. A subject not requiring thyroid medicine within the past 12 months is eligible.
• Acute disease at the time of enrolment.
• Asthma requiring daily steroid or long acting β agonist prevention.
• Unstable asthma.
• Food- or wine-induced asthma.
• Known sensitivity to sulfites or aspirin.
• Bleeding disorder that was diagnosed by a physician. A subject who states that he or she has easy bruising or bleeding, but does not carry a formal diagnosis and has intramuscular (IM) injections and blood draws without any adverse experience is eligible.
• History of any serious neurologic disorder or seizure
• History of major congenital defect
• History of chronic fatigue syndrome or fibromyalgia
• Splenectomy
• Hypertension. A subject with hypertension is eligible if he or she is controlled on medication and the documented blood pressure is less than 150/100.
• Any medical, psychiatric or social condition, or occupational or other responsibility that, in the judgement of the investigator, would interfere with or serve as a contradiction to adherence to the study protocol or ability to give informed consent.