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Sponsored by: |
Danish Headache Center |
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Information provided by: | Danish Headache Center |
ClinicalTrials.gov Identifier: | NCT00256802 |
To examine the ability of MRA to measure the effect of GTN on the intra-cranial vascular response during the GTN-induced headache in healthy volunteers.
Condition | Intervention |
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Headache, Migraine, MR-Angiography, Healthy Volunteers, GTN, Middle Cerebral Artery |
Device: MR-angiography, GTN |
Study Type: | Interventional |
Study Design: | Diagnostic, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Pharmacodynamics Study |
Official Title: | The Diameter of the Middle Cerebral Artery Measured With Magnetic Resonance Angiography (MRA) Under Provocation With Glyceryl Trinitrate in Healthy Volunteers. |
Estimated Enrollment: | 12 |
Study Start Date: | June 2004 |
Estimated Study Completion Date: | January 2005 |
The only intra cranial structures innervated by sensory nerves, and therefore a possible source of the headpain are the meninges and the large intracerebral arteries. The dilatation of the cerebral vessels may not be the origin of the head pain per se, but measurements of the intra cerebral vascular bed in the past has proven valuable in the migraine-research, and has helped elucidate the basis for the migraine aura (Olesen, Friberg et al. 1990). The effects of different signal molecules on the intra cerebral vasculature continue to be an important field in the migraine research, in the search for possible pain causing signaling molecules.
Therefore we have set up at study to examine if MR-Angiography (MRA) can be used for monitoring of the vascular response after challenge with the known vasodilator GTN. This drug was chosen because it is well characterized and a large body of evidence from earlier studies could serve as background data (Thomsen 1997).
Ages Eligible for Study: | 18 Years to 40 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | MRA-GTN2004 |
Study First Received: | November 21, 2005 |
Last Updated: | November 21, 2005 |
ClinicalTrials.gov Identifier: | NCT00256802 |
Health Authority: | Denmark: Den Centrale Videnskabsetiske Komité. |
Headache, migraine, MR-angiography, healthy volunteers, GTN, Middle cerebral artery |
Nitroglycerin Signs and Symptoms Migraine Disorders Headache Central Nervous System Diseases Neurologic Manifestations |
Headache Disorders, Primary Pain Healthy Brain Diseases Headache Disorders |
Nervous System Diseases |