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In Vitro Test Methods for Detecting Ocular Corrosives and
Severe Irritants |
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Back to Background Review Documents Page
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Introduction and Rationale for the Proposed Use of In Vitro Test Methods
to Identify Ocular Corrosives and Severe Irritants [PDF]
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Test Method Protocol Components [PDF]
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Substances Used for Validation of the ICE Test Method [PDF]
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In Vivo Reference Data Used for an Assessment of Test Method Accuracy [PDF]
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Test Method Data and Results [PDF]
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Test Method Accuracy [PDF]
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Test Method Reliability [PDF]
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Test Method Data Quality [PDF]
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Other Scientific Reports and Reviews [PDF]
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Animal Welfare Considerations [PDF]
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Practical Considerations [PDF]
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References [PDF]
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Glossary [PDF]
Appendices in PDF [1.9 MB,
84 pages]
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Appendix A - Publicly Available Protocols for the ICE Test Method [PDF]
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A1 - INVITTOX Protocol 80. The Chicken Enucleated Eye Test (CEET) - Method of
Prinsen [PDF]
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A2 - Table of ICE Protocols from the Reviewed Literature [PDF]
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Appendix B - Chemical and Product Class Information for the Substances Tested
in the ICE Test Method [PDF]
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Appendix C - In Vitro Data for Substances Tested in the ICE Assay [PDF]
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C1 - Data Sorted by Reference [PDF]
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C2 - Data Sorted by Substance Name [PDF]
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Appendix D - In Vivo and In Vitro Comparison of Ocular Irritancy
Classification [PDF]
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D1 - Data Sorted by Reference [PDF]
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D2 - Data Sorted by Substance Name [PDF]
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Appendix E - Interlaboratory Correlation Coefficients from the EC/HO Validation
Study (Balls et al., 1995) [PDF]
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