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In Vitro Test Methods for Detecting Ocular Corrosives and
Severe Irritants |
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Back to Background Review Documents Page
- Introduction and Rationale for the Proposed Use of In Vitro Test Methods
to Identify Ocular Corrosives and Severe Irritants [PDF]
- Test Method Protocol Components [PDF]
- Substances Used for Validation of the HET-CAM Test Method [PDF]
- In Vivo Reference Data Used for an Assessment of Test Method Accuracy [PDF]
- Test Method Data and Results [PDF]
- Test Method Accuracy [PDF]
- Test Method Reliability [PDF]
- Test Method Data Quality [PDF]
- Other Scientific Reports and Reviews [PDF]
- Animal Welfare Considerations [PDF]
- Practical Considerations [PDF]
- References [PDF]
- Glossary [PDF]
Appendices in PDF
[6.8 MB, 430 pages]
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Appendix A - Publicly Available Protocols for the HET-CAM Test Method [PDF]
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A1 - INVITTOX Protocol 47. The HET-CAM Test - Method of Spielmann and Liebsch [PDF]
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A2 - Table of HET-CAM Protocols from the Reviewed Literature Used to Assess
Ocular Irritancy [PDF]
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Appendix B - Chemical and Product Class Information for the Substances Tested
in the HET-CAM Test Method [PDF]
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B1 - Table of Chemical and Product Class Information
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B2 - Table of Formulation Components in Gettings et al. (1991)
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B3 - Table of Formulation Components in Gettings et al. (1994)
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B4 - Table of Formulation Components in Gettings et al. (1996)
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Appendix C - In Vitro Data for Substances Tested in the HET-CAM Test
Method [PDF]
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C1 - Test Method Protocols used to Generate In Vitro Data [PDF]
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C2 - Data Sorted by Reference [PDF]
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C3 - Data Sorted by Substance Name for IS(A) Analysis Method [PDF]
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C4 - Data Sorted by Substance for IS(A)-10 Analysis Method [PDF]
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C5 - Data Sorted by Substance for IS(A)-100 Analysis Method [PDF]
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C6 - Data Sorted by Substance for IS(B) Analysis Method [PDF]
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C7 - Data Sorted by Substance for IS(A)-10 Analysis Method [PDF]
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C8 - Data Sorted by Substance for IS(A)-100 Analysis Method [PDF]
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C9 - Data Sorted by Substance for Q-Score Analysis Method [PDF]
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C10 - Data Sorted by Substance for S-Score Analysis Method [PDF]
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Appendix D - In Vivo and In Vitro Comparison of Ocular Irritancy
Classification [PDF]
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D1 - Data Sorted by Reference [PDF]
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D2 - Data Sorted by Substance for IS(A) Analysis Method [PDF]
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D3 - Data Sorted by Substance for IS(A)-10 Analysis Method [PDF]
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D4 - Data Sorted by Substance for IS(A)-100 Analysis Method [PDF]
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D5 - Data Sorted by Substance for IS(B) Analysis Method [PDF]
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D6 - Data Sorted by Substance for IS(B)-10 Analysis Method [PDF]
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D7 - Data Sorted by Substance for IS(B)-100 Analysis Method [PDF]
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D8 - Data Sorted by Substance for Q-Score Analysis Method [PDF]
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D9 - Data Sorted by Substance for S-Score Analysis Method [PDF]
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Appendix E - Intralaboratory Repeatability and Intralaboratory Reproducibility
Data and Results for Gilleron et al. (1996, 1997) [PDF]
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E1 - Individual Egg HET-CAM Scores (Endpoints Evaluated and Overall Irritancy)
for Data of Gilleron et al. (1996) [PDF]
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E2 - Individual Egg HET-CAM Scores (Endpoints Evaluated and Overall Irritancy)
for Data of Gilleron et al. (1997) [PDF]
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E3 - Intralaboratory Repeatability Results (Expressed as %CV) for Data of
Gilleron et al. (1996) [PDF]
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E4 - Intralaboratory Repeatability Results (Expressed as %CV) for Data of
Gilleron et al. (1997) [PDF]
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E5 - Intralaboratory Reproducibility Results (Expressed as %CV) for Data of
Gilleron et al. (1996) [PDF]
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E6 - Intralaboratory Reproducibility Results (Expressed as %CV) for Data of
Gilleron et al. (1997) [PDF]
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Appendix F - Interlaboratory Reproducibility Data [PDF]
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F1 - Individual HET-CAM Test Laboratory Data for CEC (1991) [PDF]
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F2 - Average HET-CAM Scores and Coefficient of Variations for Substances
Evaluated in Hagino et al. (1999) and Ohno et al. (1999) [PDF]
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Appendix G - Interlaboratory Correlation Coefficients from the EC/HO Validation
Study (Balls et al., 1995) [PDF]
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Appendix H - Positive Control Data [PDF]
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H1 - Individual HET-CAM Egg Data for Dimethylformamide (provided by Drs.
Vanparys and van Goethem) [PDF]
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H2 - Individual HET-CAM Egg Data for Imidazole (provided by Drs. Vanparys and
van Goethem) [PDF]
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H3 - Individual HET-CAM Egg Data for Sodium Dodecyl Sulfate and Sodium
Hydroxide (provided by Drs. Spielmann and Liebsch) [PDF]
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Appendix I - Individual HET-CAM Scores for Eggs Treated with 0.9% Sodium
Chloride [PDF]
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