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Genetic toxicology is the study of compounds or physical agents that have the ability to damage the
DNA and/or chromosomes of cells. Such damage can lead to mutations that increase the likelihood of certain
diseases, such as cancer and birth defects. The U.S. Environmental Protection Agency, the U.S. Food and
Drug Administration, and the U.S. Consumer Product Safety Commission have testing requirements and
guidelines in place for assessing the genotoxicity of regulated products. ICCVAM and
its Genetic Toxicity Working Group review and provide comments to sponsors on proposed validation
studies, provide recommendations on test method nominations and submissions for alternative test
methods related to genetic toxicity, and evaluate proposed test guidelines and activities relevant
to genetic toxicity from the Organization for Economic Co-Operation and Development (OECD).
ICCVAM Comments on draft OECD Test Guideline 487, In Vitro Micronucleus Assay:
- OECD Draft Test Guideline 487: In Vitro Micronucleus Assay (December 2007) [PDF]
- Cover letter to OECD regarding ICCVAM comments on draft revised Test Guideline 487 [PDF]
- ICCVAM comments on draft revised Test Guideline 487 [PDF]
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