TARPs and KARPs: Auxiliary Proteins that Modulate AMPA- and Kainate-receptor Kinetics |
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| Launch in standalone player | |
| Air date: | Monday, January 12, 2009, 12:00:00 PM |
| Category: | Neuroscience |
| Description: | Dr. James Howe did postdoctoral training with Stuart Cull-Candy and David Colquhoun at University College London before moving to Yale to work with Murdoch Ritchie where he is currently Professor of Pharmacology. Dr. Howe's research on the glutamate receptor ion channels which mediate synaptic transmission in the brain uses biophysical approaches to explore their mechanism of action. Most recently he has worked on how TARPS modulate AMPA receptor function and will present new work on a second family of modulatory proteins for kainate receptors.
Selected Publications: Robert, A., Armstrong, N., Gouaux, J.E., and Howe, J.R. (2005). AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization. J. Neurosci. 25:3752-3762. Tomita, S., et al. (2005). Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature 435:1052-1058. For more information - NIH Neuroscience Seminar Series |
| Author: | James Howe, Ph.D., Department of Pharmacology, Yale University School of Medicine |
| Runtime: | 75 minutes |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 14850 |
| CIT Live ID: | 7133 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14850 |