National Toxicology Program

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NICEATM and ICCVAM have developed a Five-Year Plan to: Research, develop, translate, and validate new and revised non-animal and other alternative assays for integration of relevant and reliable methods into Federal agency testing programs Identify areas of high priority for new and revised non-animal and alternative assays or batteries of those assays to create a path forward for the replacement, reduction, and refinement of animal tests, when this is scientifically valid and appropriate Read the NICEATM-ICCVAM Five-Year Plan [PDF] Read the NICEATM-ICCVAM Five-Year Plan in webpage format [HTML] View Frequently Asked Questions about NICEATM and ICCVAM

Five-Year Plan Implementation Activities

NICEATM and ICCVAM have a number of activities ongoing to achieve the objectives presented in the Five-Year Plan. Please use the links below to view more information about these activities.

• ICCVAM Evaluation of a Non-Animal Assessment Approach for Evaluating Eye Irritation Potential of Antimicrobial Cleaning Products


• ICCVAM Recommendations on the Use of In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products


• ICCVAM Recommendations on the Use of In Vitro Test Methods for Detecting Ocular Corrosives and Severe Irritants


• NICEATM-ICCVAM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations


• NICEATM-ICCVAM Evaluation of the Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products


• Validation of Xenobiotic Detection Systems, Inc. LUMI-CELL® Assay of Estrogenic Activity


• ICCVAM Participation in Development of OECD Test Guidelines
  • Detection of Dermal Irritants
  • Use of In Vitro Test Methods for Detecting Ocular Corrosives and Severe Irritants
  • Detection of Endocrine-Disrupting Substances


• ICCVAM Participation in the International Cooperation on Alternative Test Methods (ICATM)

Development of the NICEATM-ICCVAM Five-Year Plan

• Poster presentation on the Five-Year Plan at the Society of Toxicology 47th Annual Meeting, March 2008:
  A Poland, M Wind, W Stokes, D Allen, S Fitzpatrick, J Kulpa-Eddy, D Hattan, A Jacobs, D McCarley, A Rispin, M Snyder, C Sprankle, R Tice, D Winters. The NICEATM-ICCVAM Five Year Plan: Creating a Path Forward to Reduce, Refine and Replace Animal Testing. View Poster
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• Summary version of the National Academy of Sciences report, "Toxicity Testing in the 21st Century: A Vision and a Strategy" (referenced in the NICEATM-ICCVAM Five-Year Plan) [PDF]


• NIEHS Press Release announcing the Five-Year Plan (February 5, 2008; view on NIEHS website)


• Federal Register notice announcing the Ten-Year Anniversary Symposium and the release of the Five-Year Plan [PDF]
  (Vol. 72, No. 245, pp. 72727-72728, December 21, 2007)


• ICCVAM Five-Year Plan Subcommittee Roster


• Federal Register notice announcing availability of the Draft Five-Year Plan and requesting public comments [PDF]
  (Vol. 72, No. 83, pp. 23832-23833, May 1, 2007)


• Public comments received on the Draft Five-Year Plan (May 1 - June 27, 2007)


• Federal Register notice requesting comments on the development of the Five-Year Plan [PDF]
  (Vol. 71, No. 218, pp. 66172-66173, November 13, 2006)


• Public comments received on the development of the Five-Year Plan (November 13 - December 31, 2006)