Effects of Exercise on Markers of Inflammation in Skeletal Muscle in Elderly Hip Fracture Patients

This study has been completed.

Sponsored by:	National Center for Research Resources (NCRR)
Information provided by:	National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:	NCT00006194

Purpose

Decreased skeletal muscle mass is a prevalent condition among the elderly, and an important cause of disability and functional decline. The declines in muscle mass associated with aging may be related to alterations in specific kinds of growth factors in the muscle. Elderly hip fracture patients often have significant decreases in muscle mass. The purpose of this study is to investigate whether an exercise program can induce changes in muscle growth factors that are associated with increases in muscle mass and strength in elderly hip fracture patients.

Condition	Intervention
Hip Fractures Muscular Atrophy	Behavioral: Exercise

MedlinePlus related topics: Exercise and Physical Fitness Fractures Hip Injuries and Disorders Hip Replacement

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Single Group Assignment

Eligibility

Ages Eligible for Study:	65 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Enrollment in HSC protocol #97-0695 "Rehabilitation Intensification Post Hip Fracture"
Community-dwelling
Hip fracture within 16 weeks of the screening assessment for protocol 97-0695
Persistent mobility and/or ADL impairments, but independent in ambulation
Modified Physical Performance Test (PPT) score between 12 and 28

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00006194

Locations

United States, Missouri
Washington University
St. Louis, Missouri, United States, 63110

Sponsors and Collaborators

National Center for Research Resources (NCRR)

More Information

Study ID Numbers:	NCRR-M01RR00036-0764, M01RR00036
Study First Received:	September 7, 2000
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00006194
Health Authority:	United States: Federal Government

Keywords provided by National Center for Research Resources (NCRR):

sarcopenia

Study placed in the following topic categories:

Pathological Conditions, Anatomical
Signs and Symptoms
Hip Fractures
Femoral Fractures
Fractures, Bone
Wounds and Injuries

Neurologic Manifestations
Disorders of Environmental Origin
Leg Injuries
Atrophy
Muscular Atrophy
Inflammation

Additional relevant MeSH terms:

Neuromuscular Manifestations
Nervous System Diseases
Hip Injuries

ClinicalTrials.gov processed this record on January 13, 2009