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National Center for Research Resources, National Institutes of Health. Providing clinical and translational researchers with the training and tools they need to transform basic discoveries into improved human health.

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NCRR's Division of Comparative Medicine helps meet the needs of biomedical researchers for high-quality, disease-free animals and specialized animal research facilities.

NCRR's Division of Biomedical Technology supports research to develop innovative technologies and helps make them accessible to the biomedical research community.

NCRR's Division of Research Infrastructure supports programs to enhance the competitiveness of investigators in underserved states and institutions and also provides funding to build, expand, remodel, or renovate research facilities throughout the nation.

NCRR's Science Education Partnership Awards are designed to improve life science literacy throughout the nation.

NCRR's Division for Clinical Research Resources provides funding to biomedical research institutions to establish and maintain specialized clinical research facilities and clinical-grade biomaterials that enable clinical and patient-oriented research.

Small Business Funding Opportunities

SBIR/STTR Links

Take Note

Small Business Funding Opportunities

Probes for Microimaging The Nervous Systemexternal link, opens in new window
PA-09-062 (R43/R44)

Development and Translation of Medical Technologies that Reduce Health Disparitiesexternal link, opens in new window
RFA-EB-09-001 (R43/R44)

Innovative Toxicity Assays of Pollutants, Therapeutics, and Drugsexternal link, opens in new window
PA-09-007 (R41/R42)

Innovative Toxicity Assays of Pollutants, Therapeutics, and Drugsexternal link, opens in new window
PA-09-006 (R43/R44)

Technological Innovations for Interdisciplinary Research Incorporating the Behavioral and Social Sciencesexternal link, opens in new window
PAR-08-202 (R43/R44)

Technological Innovations for Interdisciplinary Research Incorporating the Behavioral and Social Sciencesexternal link, opens in new window
PAR-08-201 (R41/R42)

Lab to Marketplace: Tools for Biomedical and Behavioral Researchexternal link, opens in new window
PA-08-114 (R43/R44)

New Technologies for Transient Molecular Complex Characterizationexternal link, opens in new window
PA-08-111 (R41/R42)

New Technologies for Transient Molecular Complex Characterizationexternal link, opens in new window
PA-08-110 (R43/R44)

Visualizing Biomedical Research Characteristicsexternal link, opens in new window
(Contract Solicitation) (Contrac/Etc.)

PHS 2008-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applicationsexternal link, opens in new window
PA-08-051 (R41/R42)

PHS 2008-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applicationsexternal link, opens in new window
PA-08-050 (R43/R44)

New Technology for Proteomics and Glycomicsexternal link, opens in new window
PA-07-452 (R41/R42)

New Technology for Proteomics and Glycomicsexternal link, opens in new window
PA-07-451 (R43/R44)

Innovations in Biomedical Computational Science and Technology Initiativeexternal link, opens in new window
PAR-07-161 (R41/R42)

Innovations in Biomedical Computational Science and Technology Initiativeexternal link, opens in new window
PAR-07-160 (R43/R44)

Manufacturing Processes of Medical, Dental, and Biological Technologiesexternal link, opens in new window
PA-06-013 (R43/R44)

Manufacturing Processes of Medical, Dental, and Biological Technologiesexternal link, opens in new window
PA-06-012 (R41/R42)

Other NIH Small Business Funding Opportunitiesexternal link, opens in new window
(R41/R42/R43/R44)


NCRR seeks to increase small business participation in federally supported research and development as well as the private-sector commercialization of technology developed with federal support. The center achieves this through the federal government's Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs.

During the 2007 federal fiscal year, NCRR awarded nearly $29 million to small businesses through these programs, in amounts ranging from $86,730 to $674,161.

Programs and Eligibility

Small Business Innovation Research (R43/R44) grants support domestic small businesses engaging in research and development that has the potential for commercialization. Phase I, which uses the R43 funding mechanism, typically offers up to $100,000 for six months. Phase II, which uses the R44 funding mechanism, typically offers up to $750,000 for two years. These award amounts and durations are guidelines that can be exceeded with appropriate justification.

READ FULL SBIR ELIGIBILITY CRITERIAexternal link, opens in new window

Small Business Technology Transfer (R41/R42) grants also support innovative research that results in commercial products or services that benefit the public. Funding applicants must have a formal research partnerships with universities or other non-profit research institutions. Phase I, which uses the R41 funding mechanism, typically offers up to $100,000 for one year. Phase II, which uses the R42 mechanism, typically offers up to $750,000 for two years. These award amounts and durations are guidelines that can be exceeded with appropriate justification.

READ FULL STTR ELIGIBILITY CRITERIAexternal link, opens in new window

The SBIR and STTR programs have three application periods each year. Application deadlines for these periods are April 5, August 5, and December 5.

There are significant differences between the SBIR and STTR programs. For detailed information, see the program descriptionsexternal link, opens in new window on the NIH Small Business Funding Opportunities Web site.

Scientific Program Areas and Contacts

NCRR provides SBIR and STTR funding in areas that complement its core programs:

Clinical Technology Applications

NCRR is interested in the application of clinical technology, instruments, devices, and related methodologies that may have broad application to clinical research. In particular, NCRR funds applications that enhance clinical research and patient care. READ MORE >>

Instrumentation and Specialized Technologies for Biomedical Research

NCRR supports research to discover, create, and develop innovative technologies and provides access to these technologies to the biomedical research community. READ MORE >>

Comparative Medicine

NCRR helps meet the needs of biomedical researchers for high-quality, disease-free animals and specialized animal research facilities. Of particular interest to scientists are a variety of sources for genetic analysis services, biological materials such as cultures and reagents, and online information about model organisms. READ MORE >>

Discovery-Oriented Software and Tools for Science Education

NCRR is interested in developing discovery oriented, user-friendly educational software and applying educational technology and tools to health science topics for K-12 and undergraduate students. READ MORE >>

SBIR Technical Assistance Programs

To help small businesses with SBIR funding move their products into the marketplace, NIH offers a range of technical assistance programs providing technical and commercialization assistance. These programs include:

Commercialization Assistance Program—provides assistance with developing and implementing an appropriate business strategy that will help commercialize the products that have resulted from federally funded SBIR research projects.

Niche Assessment Program—assesses if there are other applications or niches for the SBIR-developed technology and evaluates the market opportunities, needs and concerns of the end-users, and helps to discover new markets for possible entry.

Pilot Manufacturing Assistance Program—in partnership with the NIST Manufacturing Extension Partnership program, this pilot program assists SBIR awardees with making decisions when developing their operational manufacturing transition strategies. READ MOREexternal link, opens in new window

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