No. |
Method |
ICCVAM Evaluation |
U.S. Regulatory Acceptance/ Endorsement |
OECD Adoption |
EU Regulatory Acceptance/ Endorsement1 |
1 |
CORROSITEX Skin Corrosivity Test |
ICCVAM peer review and report; recommended in 1999 |
Yes, accepted by U.S. in 2000; as OECD TG 435 in 2006 |
OECD Test Guideline (TG) 435 (2006) |
Yes, via OECD |
2 |
Local Lymph Node Assay for skin sensitization |
ICCVAM peer review and report; recommended in 1999 |
Yes, accepted by U.S. in 1999; as OECD TG 429 in 2002 |
OECD TG 429 (2002) |
Yes, via OECD |
3 |
Up and Down Procedure (UDP) |
ICCVAM peer review and report; recommended in 2001 |
Yes, accepted by U.S. in 2003; as OECD TG 425 in 2003 |
OECD TG 425 (2006) |
Yes, via OECD |
4 |
Fixed Dose Procedure (FDP) |
ICCVAM Working Group (WG) contributed to TG development |
Yes, as OECD TG 420 in 2001 |
OECD TG 420 (2001) |
Yes, via OECD |
5 |
Acute Toxic Class Method (ATC) |
ICCVAM WG contributed to TG development |
Yes, as OECD TG 423 in 2001 |
OECD TG 423 (2001) |
Yes, via OECD |
6 |
EpiSkin Skin Corrosivity Test |
ICCVAM review and report; recommended in 2002 |
Yes, as OECD TG 431 in 2004 |
OECD TG 431 (2004) |
67/548/EEC |
7 |
EpiDerm Skin Corrosivity Test |
ICCVAM review and report; recommended in 2002 |
Yes, as OECD 431 in 2004 |
OECD TG 431 (2004) |
67/548/EEC |
8 |
SkinEthic Skin Corrosivity Test |
ICCVAM contributed to U.S. OECD TG review |
Yes, as OECD 431 in 2004 |
OECD 431 (2004) |
Yes, via OECD |
9 |
Rat TER Skin Corrosivity Test |
ICCVAM review and report; recommended in 2002 |
Yes, as OECD TG 430 in 2004 |
OECD TG 430 (2004) |
67/548/EEC |
10 |
3T3 NRU Phototoxicity Test |
ICCVAM contributed to U.S. OECD TG review |
Yes, as OECD TG 432 in 2004 |
OECD TG 432 (2004) |
67/548/EEC |
11 |
3T3 NRU Phototoxicity Test: Application to UV Filter Chemicals |
ICCVAM contributed to U.S. OECD TG review |
Yes, as OECD TG 432 in 2004 |
OECD TG 432 (2004) |
OECD TG 432 |
12 |
In vitro dermal absorption methods |
ICCVAM contributed to U.S. OECD TG review, expert consultation meetings |
Yes, as OECD TG 428 in 2004 |
OECD TG 428 (2004) |
Yes, via OECD |
13 |
Use of Humane Endpoints in Animal Testing of Biological Products |
ICCVAM agency initiative |
Yes, 9 CFR 117.4e |
|
|
14 |
Rabies Vaccine, Humane Endpoints |
ICCVAM agency initiative |
Yes, 9 CFR 117.4e |
|
|
15 |
Bovine Corneal Opacity and Permeability (BCOP) Test Method |
Yes, peer review and report; recommended in 2007 |
Yes, acceptance in 2008 |
(Draft TG in preparation) |
|
16 |
Isolated Chicken Eye (ICE) Test Method |
Yes, peer review and report; recommended in 2007 |
Yes, acceptance in 2008 |
(Draft TG in preparation) |
|
17 |
Acute Toxicity In Vitro Starting Dose Procedure, 3T3 cells |
Yes, 2001 workshop report; 2006 peer review and report; recommended in 2008 |
Yes |
OECD TGs 420 (2001), 423 (2001), 425 (2006) |
Yes, via OECD |
18 |
Acute Toxicity In Vitro Starting Dose Procedure, NHK cells |
Yes, 2001 workshop report; 2006 peer review and report; recommended in 2008 |
Yes |
OECD TGs 420 (2001), 423 (2001), 425 (2006) |
Yes, via OECD |
