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Mefloquine
Mefloquine would be the only drug recommended for a pregnant
woman traveling to Afghanistan. Current information suggests
that its use at prophylactic doses during the second and third
trimesters of pregnancy is not associated with adverse fetal
or pregnancy outcomes. More limited data suggest it is also
safe to use during the first trimester.
Doxycycline would be
contraindicated because of potential adverse effects on the
fetus (discoloration and dysplasia of the teeth and inhibition
of bone growth). Because of insufficient information on the
use of atovaquone-proguanil, this drug is not currently recommended
for prevention of malaria in pregnant women. However, if
at all possible, women who are pregnant or likely to become
pregnant should be advised to avoid travel in areas with malaria
risk, because: a) malaria in pregnant women can be more severe
than in non-pregnant women; b) malaria can increase the risk
of adverse pregnancy outcomes, including prematurity, abortion
and stillbirth; and c) no chemoprophylactic regimen offers complete
protection.
Page last modified : April 23, 2004
Content source: Division of Parasitic Diseases
National Center for Zoonotic, Vector-Borne, and Enteric Diseases (ZVED)
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