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Atovaquone-proguanil
(Malarone®)
Atovaquone-proguanil would be the drug of choice because of its demonstrated
efficacy, low frequency of side effects, and relative ease of administration
(single daily dose for 3 days). Mefloquine would also be effective but has
a greater risk of side effects at therapeutic doses. Quinine plus doxycycline
would also be effective, but requires a more complex regimen of administration
over seven days, and quinine can produce side effects (tinnitus). Artesunate
would be effective, but requires a complex regimen of administration over
5 - 7 days, and is not yet approved by the US Food and Drug Administration.
Halofantrine is not recommended because of its association with cardiotoxicity.
(If the person has been taking prophylaxis when the suspected malaria
attack occurs, the drug used for presumptive treatment should not
be the same as the drug used for prophylaxis!)
Page last modified : April 23, 2004
Content source: Division of Parasitic Diseases
National Center for Zoonotic, Vector-Borne, and Enteric Diseases (ZVED)
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