The President's Council of Advisors on Science and Technology issues 2008 report on Priorities for Personalized Medicine (2008). (7 MB)
	New genetics fellowship position with CDC’s Division of Laboratory Systems in the National Center for Preparedness, Detection, and Control of Infectious Disease. Read the announcement. (75 KB) For more information, contact Ira Lubin at ilubin@cdc.gov.
	New scientific journal Circulation: Cardiovascular Genetics  releases first issue.
	UPDATED! The Oregon State Genetics Program releases 2007 results on BRFSS questions (41 KB) related to family history of cardiovascular disease and direct-to-consumer marketing of genetic tests, as well as 2007 results from the General Knowledge Survey (146 KB) , a telephone health survey about health knowledge and beliefs related to genetics and family history.
	What's New in HuGENet™ October 2008

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

NQO1 Polymorphisms and De Novo Childhood Leukemia: A HuGE Review and Meta-Analysis Guha N, et al. Am J Epidemiol 2008 Oct

HGVbaseG2P: a central genetic association database
Thorisson GA, et al.
Nucleic Acids Res 2008 Oct

PharmGKB: understanding the effects of individual genetic variants
Sangkuhl K, et al.
Drug Metab Rev 2008;40(4):539-51

Genetic predisposition to statin myopathy
Vladutiu GD
Curr Opin Rheumatol 2008 Nov;20(6):648-55

Genetic prediction of renal transplant outcome
Goldfarb-Rumyantzev AS & Naiman N
Curr Opin Nephrol Hypertens 2008 Nov;17(6):573-9

Risk-reduction surgery in BRCA mutation carriers in a Spanish population: adherence and results
Perez Segura P, et al.
Clin Transl Oncol 2008 Oct;10(10):660-4

Lactose intolerance--genotyping simplifies and improves diagnosis
Vestergaard EM, et al.
Ugeskr Laeger 2008 Oct;170(42):3312-4

Genome-wide association studies
Feenstra B, et al.
Ugeskr Laeger 2008 Oct;170(41):3216-20

Dominant versus recessive: Molecular mechanisms in metabolic disease
Zschocke J
J Inherit Metab Dis 2008 Oct

Detecting Interactions in Association Studies by Using Simple Allele Recoding
Sillanpaa MJ
Hum Hered 2008 Oct;67(1):69-75

Optimal DNA Pooling-Based Two-Stage Designs in Case-Control Association Studies
Zhao Y & Wang S
Hum Hered 2008 Oct;67(1):46-56

MDPD: an integrated genetic information resource for Parkinson's disease
Tang S, et al.
Nucleic Acids Res 2008 Oct

Impact and Quantification of the Sources of Error in DNA Pooling Designs
Jawaid A & Sham P
Ann Hum Genet 2008 Oct

Understanding emotional responses to breast/ovarian cancer genetic risk assessment: an applied test of a cognitive theory of emotion
Phelps C, et al.
Psychol Health Med 2008 Oct;13(5):545-58

Genome-wide association studies in neurological disorders
Simon-Sanchez J & Singleton A
Lancet Neurol 2008 Nov;7(11):1067-72

Locus-specific databases and recommendations to strengthen their contribution to  the classification of variants in cancer susceptibility genes
Greenblatt MS, et al.
Hum Mutat 2008 Oct;29(11):1273-81

Psychosocial outcome following genetic risk counselling for familial colorectal cancer. A comparison of affected patients and family members
Keller M, et al.
Clin Genet 2008 Nov;74(5):414-24

Genetic epidemiology: the use of old and new tools for multiple sclerosis
Ramagopalan SV, et al.
Trends Neurosci 2008 Oct

Perceptions of Familial Risk in those Seeking a Genetic Risk Assessment for Alzheimer's Disease
Hiraki S, et al.
J Genet Couns 2008 Oct

Occupational exposure to dust, gases and fumes, a family history of asthma and impaired respiratory health
Hedlund U, et al.
Scand J Work Environ Health 2008 Oct;34(5):381-6

 

A Systematic Review of the Effects of Disclosing Carrier Results Generated Through Newborn Screening
Hayeems RZ, et al.
J Genet Couns 2008 Oct

Sequence variant classification and reporting: recommendations for improving the  interpretation of cancer susceptibility genetic test results
Plon SE, et al.
Hum Mutat 2008 Oct;29(11):1282-91

Changing interpretations, stable genes: responsibilities of patients, professionals, and policy makers in the clinical interpretation of complex genetic information
Shirts BH & Parker LS
Genet Med 2008 Oct

The brave new era of human genetic testing
Bandelt HJ, et al.
Bioessays 2008 Nov;30(11-12):1246-51

Genetic Testing in Clinical Practice
Lamberts SW & Uitterlinden AG
Annu Rev Med 2008 Oct

 

Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder
Lasky-Su J, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Oct

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending October 29, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page