October is National Breast Cancer Awareness Month. See the USPSTF recommendations on BRCA mutation testing for breast and ovarian cancer susceptibility, and learn more about breast cancer from the CDC and NIH.
	NIH's National Institute on Alcohol Abuse and Alcoholism is now accepting applications for projects on epigenomics of human health and disease. Read the announcement.
	New article, Genes and Health published in the Fall 2008 issue of the CDC Foundation newsletter FrontLine. Read about genomics activities and achievements of CDC's National Office of Public Health Genomics.

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer
More Women Undergoing Breast, Ovarian Cancer Genetic Testing,  NBC6.net, October 9	Womansday.com survey asks how much do you know about your cancer risk,  Market Watch, October 6
Breast cancer gene tests — not worth the price,  MSNBC, October 9	October is National Breast Cancer Awareness Month,  Woodlands Online, October 6
Firm says test judges risk for common breast cancers,  Washington Post, October 8	Documenting a devastating genetic illness,  Chicago Tribune, October 5
Researchers kill off pancreatic cancer cells with ‘suicide gene’,  Drug Discovery News, October 7	Psychological impact of gene test for breast cancer,  Medical News Today, October 5

Design of the BRISC study: a multicentre controlled clinical trial to optimize the communication of breast cancer risks in genetic counselling Ockhuysen-Vermey CF, et al. BMC Cancer 2008 Oct;8(1):283

The Renin-Angiotensin-Aldosterone System: Approaches to Guide Angiotensin-Converting Enzyme Inhibition in Patients with Coronary Artery Disease
Brugts JJ, et al.
Cardiology 2008 Oct;112(4):303-12

Genetic Variations in Cytokines and Cytokine Receptors Associated with Psoriasis  Found by Genome-Wide Association
Duffin KC & Krueger GG
J Invest Dermatol 2008 Oct

Long QT Syndrome
Goldenberg I, et al.
Curr Probl Cardiol 2008 Nov;33(11):629-94

A Combinatorial Approach to Detecting Gene-Gene and Gene-Environment Interactions in Family Studies
Lou XY, et al.
Am J Hum Genet 2008 Oct

Chronic heart failure: beta-blockers and pharmacogenetics
Azuma J & Nonen S
Eur J Clin Pharmacol 2008 Oct

Contralateral Risk-Reducing Mastectomy in Young Breast Cancer Patients with and without Genetic Cancer Risk Assessment
Mai PL, et al.
Ann Surg Oncol 2008 Oct

What do we know about the genetics of aspirin intolerance?
Palikhe NS, et al.
J Clin Pharm Ther 2008 Oct;33(5):465-72

New advances in hematopoietic cell transplantation
Petersdorf EW & Hansen JA
Curr Opin Hematol 2008 Nov;15(6):549-54

The challenges for molecular nutrition research 3: comparative nutrigenomics research as a basis for entering the systems level
Daniel H, et al.
Genes Nutr 2008 Oct

A customized genetic approach to the number one killer: coronary artery disease
Roberts R
Curr Opin Cardiol 2008 Nov;23(6):629-33

Mammographic screening for young women with a family history of breast cancer: knowledge and views of those at risk
Tyndel S, et al.
Br J Cancer 2008 Oct;99(7):1007-12

The influence of parental history of Alzheimer's disease and apolipoprotein E {varepsilon}4 on the BOLD signal during recognition memory
Xu G, et al.
Brain 2008 Oct

The analysis of genetics and associated autoimmune diseases in Chinese vitiligo patients
Zhang Z, et al.
Arch Dermatol Res 2008 Oct

Familial clustering of Crohn's disease in Israel: Prevalence and association with disease severity
Ben-Horin S, et al.
Inflamm Bowel Dis 2008 Oct

Family history of type 2 diabetes is increased in patients with type 1 diabetes
Barone B, et al.
Diabetes Res Clin Pract 2008 Oct;82(1):e1-4

The effect of parental type 2 diabetes on the offspring with type 1 diabetes
Thorn LM, et al.
Diabetes Care 2008 Oct

 

Guidance for considering ethical, legal, and social issues in health technology assessment: Application to genetic screening
Potter BK, et al.
Int J Technol Assess Health Care 2008 Fall;24(4):412-22

All in the family: Disclosure of "unwanted" information to an adolescent to benefit a relative
Denny CC, et al.
Am J Med Genet A 2008 Oct

 

Association of three genetic loci with uric acid concentration and risk of gout:  a genome-wide association study
Dehghan A, et al.
Lancet 2008 Sep

A genome-wide association study identifies an association of a common variant in  TERT with susceptibility to idiopathic pulmonary fibrosis
Mushiroda T, et al.
J Med Genet 2008 Oct;45(10):654-6

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending October 8, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page