Genetic Information Nondiscrimination Act (GINA)  approved by the U.S. House of Representatives (414-1) today! President Bush is expected to sign the bill. GINA will protect against the misuse of Americans' genetic information.
	The Newborn Screening Saves Lives Act of 2007 was signed into law by President Bush Thursday, April 24. Read a summary of this Act.
	New publication, GAPscreener: An Automatic Tool for Screening Human Genetic Association Literature in PubMed Using the Support Vector Machine Technique,  published in the April 22 2008 issue of BMC Bioinformatics. Authors: Yu W, Clyne M, Dolan SM, Yesupriya A, Wulf A, Liu T, Khoury MJ, Gwinn M. The GAPscreener software can be downloaded free of charge from the HuGE Navigator Web site.

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Genetic association tests in the presence of epistasis or gene-environment interaction
Wang K
Genet Epidemiol 2008 Apr

Genomics, heart failure and sudden cardiac death
Darbar D
Heart Fail Rev 2008 Apr

GAPscreener: An Automatic Tool for Screening Human Genetic Association Literature in PubMed Using the Support Vector Machine Technique
Yu W, et al.
BMC Bioinformatics 2008 Apr;9(1):205

beta-Blocker pharmacogenetics in heart failure
Shin J & Johnson JA
Heart Fail Rev 2008 Apr

The Genetic Aspects of Pre-eclampsia: Achievements and Limitations
Nejatizadeh A, et al.
Biochem Genet 2008 Apr

Mutations in human monoamine-related neurotransmitter pathway genes
Haavik J, et al.
Hum Mutat 2008 Apr

The interaction of genetic polymorphisms with lifestyle factors: implications for the dietary prevention of prostate cancer
Nelson EC, et al.
Nutr Cancer 2008 May-2008 Jun;60(3):301-12

Pharmacogenetics in ovarian stimulation--current concepts
Loutradis D, et al.
Ann N Y Acad Sci 2008 Apr;1127:10-9

Hereditary diffuse gastric cancer : diagnosis, genetic counseling, and prophylactic total gastrectomy
Lynch HT, et al.
Cancer 2008 Apr

Androgens and the molecular epidemiology of prostate cancer
Chu LW, et al.
Curr Opin Endocrinol Diabetes Obes 2008 Jun;15(3):261-70

Gene-Environment Interactions in the Development of Complex Disease Phenotypes
Ramos RG & Olden K
Int J Environ Res Public Health 2008 Mar;5(1):4-11

The genetics of suicide: a critical review of molecular studies
Brezo J, et al.
Psychiatr Clin North Am 2008 Jun;31(2):179-203

P450 oxidoreductase: genetic polymorphisms and implications for drug metabolism and toxicity
Hart SN & Zhong XB
Expert Opin Drug Metab Toxicol 2008 Apr;4(4):439-52

Pharmacogenetics of aspirin resistance: a comprehensive systematic review
Goodman T, et al.
Br J Clin Pharmacol 2008 Apr

Testing for association on the X chromosome
Clayton D
Biostatistics 2008 Apr

GenoWatch: a disease gene mining browser for association study
Chen YH, et al.
Nucleic Acids Res 2008 Apr

Stress, genes and the biology of suicidal behavior
Currier D & Mann JJ
Psychiatr Clin North Am 2008 Jun;31(2):247-69

Schizophrenia: genome, interrupted
Cantor RM & Geschwind DH
Neuron 2008 Apr;58(2):165-7

Family communication between children and their parents about inherited genetic conditions: a meta-synthesis of the research
Metcalfe A, et al.
Eur J Hum Genet 2008 Apr

Population-based estimates of the relation between breast cancer risk, tumor subtype, and family history
Welsh ML, et al.
Breast Cancer Res Treat 2008 Apr

 

Loci Related to Metabolic-Syndrome Pathways Including LEPR,HNF1A, IL6R, and GCKR  Associate with Plasma C-Reactive Protein: The Women's Genome Health Study
Ridker PM, et al.
Am J Hum Genet 2008 Apr

Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer
Stacey SN, et al.
Nat Genet 2008 Apr

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending April 30, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page