University of Michigan hosts Grand Rounds on Genomics Research, Policy and Practice. Read summary in June 27, 2008 issue of the ASPH Friday Letter. View keynote speech (webcast) by Muin J. Khoury MD, PhD, director, National Office of Public Health Genomics, CDC.
	Summary of the Institute of Medicine’s Roundtable on Translating Genomic-Based Research for Health: Diffusion and Use of Genomic Innovations in Health and Medicine, held April 1-2, 2008.

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer
Microchip-based device determines the genetic signature of lung tumors, News-Medical.com, July 3	Faulty DNA repair may increase lung cancer risk in nonsmokers, Medical News Today, June 27
Discovery of gene mechanism could lead to new therapeutic strategies to fight metastatic disease, News-Medical.com, July 1	Possible link between gene variants (snps) and prostate cancer risk, Medical News Today, June 27

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database Allen NC, et al. Nat Genet 2008 Jul;40(7):827-34

Polygenes, risk prediction, and targeted prevention of breast cancer
Pharoah PD, et al.
N Engl J Med 2008 Jun;358(26):2796-803

Genetic factors in drug metabolism
Belle DJ & Singh H
Am Fam Physician 2008 Jun;77(11):1553-60

An update on the pathophysiology and genetics of restless legs syndrome
Trotti LM, et al.
Curr Neurol Neurosci Rep 2008 Jul;8(4):281-7

Evaluating the Effects of Imputation on the Power, Coverage, and Cost Efficiency  of Genome-wide SNP Platforms
Anderson CA, et al.
Am J Hum Genet 2008 Jun

Hereditary breast cancer: new genetic developments, new therapeutic avenues
Campeau PM, et al.
Hum Genet 2008 Jun

Pharmacogenetic treatments for drug addiction: alcohol and opiates
Haile CN, et al.
Am J Drug Alcohol Abuse 2008;34(4):355-81

Genetic polymorphisms and endometrial cancer risk
Meyer LA, et al.
Expert Rev Anticancer Ther 2008 Jul;8(7):1159-67

A Test for Genetic Association that Incorporates Information about Deviation from Hardy-Weinberg Proportions in Cases
Wang J & Shete S
Am J Hum Genet 2008 Jun

Accuracy of Family History of Hemochromatosis or Iron Overload: The Hemochromatosis and Iron Overload Screening Study
Acton RT, et al.
Clin Gastroenterol Hepatol 2008 Jun

Familiality of major depressive disorder and patterns of lifetime comorbidity. The NEMESIS and GenMood studies : A comparison of three samples
Verhagen M, et al.
Eur Arch Psychiatry Clin Neurosci 2008 Jun

Family history of malignancies and risk of breast cancer: prospective data from the Shanghai women's health study
Kilfoy BA, et al.
Cancer Causes Control 2008 Jun

Family History of Pancreatic Cancer in a High-Risk Cancer Clinic: Implications for Risk Assessment
Hall MJ, et al.
J Genet Couns 2008 Jun

 

Tolerance for ambiguity could influence awareness of breast cancer genetic testing and inform health education
Quillin JM, et al.
Cancer Causes Control 2008 Jul

A model for offering carrier screening for fragile X syndrome to nonpregnant women: results from a pilot study
Metcalfe S, et al.
Genet Med 2008 Jun

Confidentiality, privacy, and security of genetic and genomic test information in electronic health records: points to consider
McGuire AL, et al.
Genet Med 2008 Jun

Primary care physicians' willingness to offer a new genetic test to tailor smoking treatment, according to test characteristics
Shields AE, et al.
Nicotine Tob Res 2008 Jun;10(6):1037-45

Infant hearing loss and connexin testing in a diverse population
Schimmenti LA, et al.
Genet Med 2008 Jun

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending July 2, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies

For more information on HuGE, please visit the HuGENet™ home page