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 Thursday, December 18, 2008 Volume 21   Number 24
Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genomic research on disease prevention & population health. open mailbox for email deliveryGet email updates
Spotlight

figures standing on a helix NIH and CDC Convene Personal Genomics Workshop
On December 17-18, 2008, the National Institutes of Health and the Centers for Disease Control and Prevention convened a workshop, Establishing the Scientific Foundation for Using Personal Genome Profiles for Risk Assessment, Health Promotion, and Disease Preventionnon-gov warning icon in Bethesda, Maryland. Presentations and other materials from this meeting will be posted soon.

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 Upcoming Events
Genomics Announcements
   
CDC logo
CDC's National Office of Public Health Genomics is looking for a nurse consultant. For more information about the position, click on the U.S. Department of Health and Human Services web site non-gov warning icon and enter the vacancy number (HHS-CDC-T2-2009-0188 pdf only (408KB) – for current employees or HHS-CDC-D2-2009-0085 pdf only (318KB) – for non-federal applicants). The deadline to apply is December 31, 2008.
   
CDC logo

Two new family history-related articles published in the January 2009 issue of Preventing Chronic Disease: Influence of Family History of Diabetes on Health Care Provider Practice and Patient Behavior Among Nondiabetic Oregonians, authors: Zlot AI, Bland MP, Silvey K, Epstein B, Mielke B, Leman RF., and Developing Family Healthware, a Family History Screening Tool to Prevent Common Chronic Diseases, authors: Yoon PW, Scheuner MT, Jorgensen C, Khoury MJ.

   
Department of Health and Human Services, USA
New version of My Family Health Portrait Internet-based family health history tool to be released by the U.S. Surgeon General in January 2009. Read more  pdf only (24 KB)
   
CDC logo

Summer Institute in Public Health Genetics: Translating Genomics into Policy and Practice pdf only (66 KB) offered by the University of Washington Center for Genomics & Public Health and CDC's National Office of Public Health Genomics on June 22-26, 2009, in Seattle, Washington. For more information, send an email to: cgph@u.washington.edu.

   
Department of Health and Human Services, USA

Become part of the U.S. Department of Health and Human Services Healthy People Consortium or submit your comments and suggestions as part of a collaborative process of building Healthy People 2020.


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Cancer

New anti-tumor gene called SARI, non-gov warning icon News-Medical.Net, December 16

SABCS: Breast cancer risk varies in young women with benign breast... non-gov warning icon Medpage Today, December 15

Breast cancer genome shows instability of cancer, non-gov warning icon News-Medical.Net, December 16

Stopping ovarian cancer by blocking proteins coded by notorious gene, non-gov warning icon EurekAlert, December 15

Gene subnetworks provide new prognostic markers for breast... non-gov warning icon News-Medical.Net, December 16

Test all colon cancers for inherited form, non-gov warning icon Emax Health, December 15

GUMC researchers find gene inactivated in two aggressive cancers, non-gov warning icon News-Medical.Net, December 15

Postmenopausal patients being considered for tamoxifen therapy... non-gov warning icon News-Medical.Net, December 14

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Cardiovascular Health

Single letter in the human genome points to risk for high cholesterol, non-gov warning icon News-Medical.Net, December 16

New cause of heart arrhythmia found, non-gov warning icon Medical News Today, December 12

Amish have gene that keeps blood fats down and may protect heart, non-gov warning icon Medical News Today, December 12

 

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Ethical, Legal and Social Issues (ELSI)

VCU survey: US public supports genetic research, testing and government spending on research, non-gov warning icon EurekAlert, December 17

Publication announcement - Public expectations for return of results from large-cohort genetic research, non-gov warning icon Medical News Today, December 15

FDA verdict could determine future of personalized medicine, non-gov warning icon Forbes, December 15

SABCS: Women at genetic risk of breast cancer don't want to hear it by phone, non-gov warning icon Medpage Today, December 12

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Family History

Family history updates recommended in breast cancer survivors, non-gov warning icon cancerpage.com, December 11

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Genetic Testing

New test aims to predict breast cancer risk better, non-gov warning icon ajc.com, December 17 DeCODE turning genes into medical practice, non-gov warning icon ZDNet, December 15

Medcan first in Canada to offer genetic testing for Warfarin, non-gov warning icon CNW Group, December 16

Exiqon announces launch of first molecular diagnostic test for colon cancer, non-gov warning icon Market Watch, December 15

Archived blood from infant heel stick tests could lead to discoveries about diseases that have roots in perinatal period, non-gov warning icon News-Medical.Net, December 16

New test may predict breast cancer risk better, non-gov warning icon wpxi.com, December 12

Rosetta Genomics launches first test, non-gov warning icon Washington G-2 Reports, December 16

 

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Mental Health

MU researcher identifies possible genetic causes of borderline personality disorder, non-gov warning icon Medical News Today, December 18

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Nutrigenomics

New gene variants present opportunities in nutrigenomics, non-gov warning icon EurekAlert, December 15

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Obesity

Discovery of seven new sites in the human genome found to influence obesity, non-gov warning icon News-Medical.Net, December 15

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Other News

DeCODE discovers common genetic variations contributing to low bone mineral density and risk of osteoporosis, non-gov warning icon Medical News Today, December 16

NIH expands open-access dataset of genetic and clinical data to include asthma, non-gov warning icon NIH News, December 15

Premature Aging Disease: Gene discovery to clinical trial of potential treatment, all done in just 5 years, non-gov warning icon Science Daily, December 16

Metagene 'portraits' used by UC San Diego researchers to reveal distinct stages of kidney formation, non-gov warning icon Medical News Today, December 12

New genetic cause of boy in the bubble syndrome, non-gov warning icon EurekAlert, December 15

 
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Genomics in Scientific Literature
Featured Item
Gene Prospector: An evidence gateway for evaluating potential susceptibility genes and interacting risk factors for human diseases
Yu W, et al.
BMC Bioinformatics 2008 Dec;9(1):528

 General Articles

Public health genomics: translating obesity genomics research into population health benefits
Agurs-Collins T, et al.
Obesity (Silver Spring) 2008 Dec;16 Suppl 3:S85-94

Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme
Whitehead J, et al.
Pharm Stat 2008 Dec

Ethical considerations in psychiatric genetics
Hoop JG
Harv Rev Psychiatry 2008;16(6):322-38

Predictive Genomics of Cardioembolic Stroke
Ramoni RB, et al.
Stroke 2008 Dec

Nutritional genomics and dietetic professional practice
Ryan-Harshman M, et al.
Can J Diet Pract Res 2008 Winter;69(4):177-82

Genome-wide association studies in the genetics of asthma
Willis-Owen SA, et al.
Curr Allergy Asthma Rep 2009 Jan;9(1):3-9

Genetic susceptibility in Parkinson's disease
Bras JM & Singleton A
Biochim Biophys Acta 2008 Nov

Pharmacogenetics: from description to prediction
Weber WW
Clin Lab Med 2008 Dec;28(4):499-511

The contribution of genes to osteoarthritis
Valdes AM & Spector TD
Med Clin North Am 2009 Jan;93(1):45-66

Genetics of ischemic stroke: inheritance of a sporadic disorder
Ross OA & Meschia JF
Curr Neurol Neurosci Rep 2009 Jan;9(1):19-27

Clinical implications of low-penetrance breast cancer susceptibility alleles
Freisinger F & Domchek SM
Curr Oncol Rep 2009 Jan;11(1):8-14

Progress and challenges in genome-wide association studies in humans
Donnelly P
Nature 2008 Dec;456(7223):728-31

Pharmacogenetics of asthma
Lima JJ, et al.
Curr Opin Pulm Med 2009 Jan;15(1):57-62

Detecting Gene-Environment Interactions Using a Combined Case-Only and Case-Control Approach
Li D & Conti DV
Am J Epidemiol 2008 Dec

Pharmacogenomics of G Protein-Coupled Receptor Ligands in Cardiovascular Medicine
Rosskopf D & Michel MC
Pharmacol Rev 2008 Dec

 
 Family History

Developing family healthware, a family history screening tool to prevent common chronic diseases
Yoon PW, et al.
Prev Chronic Dis 2009 Jan;6(1):A33

Influence of family history of diabetes on health care provider practice and patient behavior among nondiabetic oregonians
Zlot AI, et al.
Prev Chronic Dis 2009 Jan;6(1):A27

Familial lung cancer risk among women in Poland
Rachtan J, et al.
Lung Cancer 2008 Dec

 

 Genetic Testing

Dystrophin gene analysis in Hungarian Duchenne/Becker muscular dystrophy families - Detection of carrier status in symptomatic and asymptomatic female relatives
Piko H, et al.
Neuromuscul Disord 2008 Dec

Psychosocial impact of presymptomatic genetic testing for transthyretin amyloidotic polyneuropathy
Graceffa A, et al.
Neuromuscul Disord 2008 Dec

Clinical question: When should genetic testing be obtained in a patient with pheochromocytoma or paraganglioma?
Erlic Z & Neumann HP
Clin Endocrinol (Oxf) 2008 Dec

Barriers to Genetic Testing Among Persons at Risk for Alpha-1 Antitrypsin Deficiency
Dickson MR, et al.
Genet Test 2008 Dec;12(4):501-5

Development and Pilot Testing of a Decision Aid for Men Considering Genetic Testing for Breast and/or Ovarian Cancer-Related Mutations (BRCA1/2)
Juan AS, et al.
Genet Test 2008 Dec;12(4):523-32

Analysis: Secretary's Advisory Committee on Genetics, Health, and Society Report  falls short
Klein RD
Hum Pathol 2008 Dec

 

 Genome Wide

Variants in TF and HFE Explain approximately 40% of Genetic Variation in Serum-Transferrin Levels
Benyamin B, et al.
Am J Hum Genet 2008 Dec

Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk
Moskvina V, et al.
Mol Psychiatry 2008 Dec

Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study
Mead S, et al.
Lancet Neurol 2009 Jan;8(1):57-66

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Willer CJ, et al.
Nat Genet 2008 Dec

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
Thorleifsson G, et al.
Nat Genet 2008 Dec

Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
Sullivan PF, et al.
Mol Psychiatry 2008 Dec

 

 HuGE

Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease
Smyth DJ, et al.
N Engl J Med 2008 Dec

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Page last updated: December 18, 2008 (archived document)
Content Source: National Office of Public Health Genomics