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 Thursday, December 11, 2008 Volume 21   Number 23
Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genomic research on disease prevention & population health. open mailbox for email deliveryGet email updates
Spotlight

blue helixCDC Funds New Genomics Translation Projects
CDC’s National Office of Public Health Genomics has awarded funding for five new projects to state health departments and academic and research institutions for translating human-genome information and applications into education, surveillance, and policy interventions. Read more.

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blue dotGenomics In The News
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Genomics Announcements
   
bullhorn

New article, Comparison of risk persceptions nad beliefs across common chronic diseases,non-gov warning icon to be published in Preventive Medicine.non-gov warning icon Authors: Wang C, O'Neill SM, Rothrock N. Gramling R, Sen A, Acheson LS, et al. and for the Family Healthware(tm) Impact Trial (FHITr) group.

   
CDC logo

New article, Gene Prospector: An evidence gateway for evaluating potential susceptibility genes and interacting risk factors for human diseases,non-gov warning icon published in the December 2008 issue of BMC Bioinformatics. Authors: Yu W, Wulf A, Liu T, Khoury MJ, and Gwinn M.

   
CDC logo

Summer Institute in Public Health Genetics: Translating Genomics into Policy and Practice pdf only (66 KB) offered by the University of Washington Center for Genomics & Public Health and CDC's National Office of Public Health Genomics on June 22-26, 2009, in Seattle, Washington. For more information, send an email to: cgph@u.washington.edu.

   
Department of Health and Human Services, USA

Become part of the U.S. Department of Health and Human Services Healthy People Consortium or submit your comments and suggestions as part of a collaborative process of building Healthy People 2020.


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

 

Birth Defects
Calls for all pregnant women to be screened for Down syndrome, non-gov warning icon News-Medical.Net, December 8 Breakthrough in sickle cell disease and thalassemia research, non-gov warning icon News-Medical.Net, December 5

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Cancer

Gene mutation that causes eye cancer discovered by UBC researchers, non-gov warning icon Medical News Today, December 11

Networks of interactive genes may predict Leukemia's development, non-gov warning icon News-Medical.Net, December 8

Seattle Genetics reports durable objective responses with SGN-35 in lymphoma - American Society of Hematology 50th Annual Meeting, non-gov warning icon Medical News Today, December 8

Few Ontario women with invasive ovarian cancer referred for genetic testing of breast cancer genes, non-gov warning icon Medical News Today, December 6

Genetic signature may lead to better treatments for pediatric liver cancers, non-gov warning icon News-Medical.Net, December 8

 

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Diabetes

Genetic links found between type 1 diabetes and celiac disease, non-gov warning icon News-Medical.Net, December 10 deCODE to integrate new genetic risk factor for type 2 diabetes into its personal genome scan service, non-gov warning icon News-Medical.Net, December 8
Genetic variant, poor glycemic control linked to coronary artery disease, non-gov warning icon Science Daily, December 9 Body clock and sleep patterns linked to diabetes and high blood sugar, non-gov warning icon News-Medical.Net, December 7

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ELSI

Many parents clueless about newborn genetic tests, non-gov warning icon wcco.com, December 10

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Family History

Know your family's medical history, know your risk, non-gov warning icon Orlando Sentinel, December 9 Family history of breast cancer increases risk regardless of BRCA status, non-gov warning icon Cancer Consultants.com, December 4

Families to be screened for heart disease, non-gov warning icon Wales Online, December 8

 

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Mental Health

PTSD risk rooted in stress and genetics, non-gov warning icon MSN, December 9

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Genetic Testing

Genetic testing for breast cancer, non-gov warning icon Tampa Bay 10, December 11 Faster genetic diagnosis for hereditary diseases enabled by new technique, non-gov warning icon Medical News Today, December 9
All couples should be offered genetic test for spinal muscular atrophy, says the ACMG, non-gov warning icon Medical News Today, December 10 U.K. geneticists concerned patent ruling on breast cancer gene test could stifle innovation, non-gov warning icon Medical New Today, December 8

The day I had my genes tested, non-gov warning icon The Hindu, December 10

Genetic self testing, non-gov warning icon Newsdesk, December 5

Genetic test for Adolescent Idiopathic Scoliosis launched, non-gov warning icon Emax Health, December 10

My genes and me, non-gov warning icon Forbes, December 4

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Obesity

Gene variant makes children eat more calories, non-gov warning icon Medical News Today, December 11

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Personalized Health Care

Gene tests: progress and pandora's box, non-gov warning icon Medical New Today, December 5

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Smoking, Tobacco, and Alchohol

Genetic underpinnings of nicotine addiction probed by Penn researchers, non-gov warning icon Medical News Today, December 10

Genetics of alcohol response, non-gov warning icon Scientist Live, December 10

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Other News

Best careers 2009: Genetic counselor, non-gov warning icon US News & World Report, December 11 Genes for nine health indicators: Population study finds genetics clues, non-gov warning icon News-Medical.Net, December 7
Gene therapy effective treatment against gum disease, non-gov warning icon EurekAlert, December 11 Study finds six genetic variants associated with 'bad' cholesterol, non-gov warning icon News-Medical.Net, December 7
Genetic disease commonly misdiagnosed as urological disorder leads to unnecessary surgery in 75% of cases..., non-gov warning icon Marketwire, December 10

"MEDNIK:" A Novel genetic syndrome, non-gov warning icon Medical New Today, December 5

Irritable bowel syndrome can have genetic causes, non-gov warning icon Physorg.com, December 10

Prioritization of disease-associated SNPs improved by new approach, non-gov warning icon Medical New Today, December 5

WU genomics class expands to other schools, non-gov warning icon Student Life, December 8

An enhanced tool for storage and mining of genome-wide expression data, non-gov warning icon HUM-MOLGEN, December 4

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Genomics in Scientific Literature
Featured Item

Sample size requirements to detect the effect of a group of genetic variants in case-control studies
Moonesinghe R, et al.
Emerg Themes Epidemiol 2008 Dec;5(1):24


 General Articles

Degenerative periodontal-diseases and oral osteonecrosis: The role of gene-environment interactions
Baldi D, et al.
Mutat Res 2008 Nov

An update on pharmacogenomics in rheumatoid arthritis with a focus on TNF-blocking agents
Ranganathan P
Curr Opin Mol Ther 2008 Dec;10(6):562-7

Pharmacogenomics of statin response
Mangravite LM, et al.
Curr Opin Mol Ther 2008 Dec;10(6):555-61

Identification of new genetic risk factors for prostate cancer
Guy M, et al.
Asian J Androl 2008 Dec

Genetic issues in patients with breast cancer
Fossland VS, et al.
Surg Oncol Clin N Am 2009 Jan;18(1):53-71

Genetic risk assessment, counseling and testing
Rich TA & Salazar M
Surg Oncol Clin N Am 2009 Jan;18(1):19-38

Genetic epidemiology of bladder cancer: scaling up in the identification of low-penetrance genetic markers of bladder cancer risk and progression
Malats N
Scand J Urol Nephrol Suppl 2008 Sep(218):131-40

A critical evaluation of genomic control methods for genetic association studies
Dadd T, et al.
Genet Epidemiol 2008 Dec

Is obesity our genetic legacy?
Blakemore AI & Froguel P
J Clin Endocrinol Metab 2008 Nov;93(11 Suppl 1):S51-6

Experiences of genetic counseling for BRCA1/2 among recently diagnosed breast cancer patients: a qualitative inquiry
Vadaparampil ST, et al.
J Psychosoc Oncol 2008;26(4):33-52

An overview of genetic influences in alcoholism
Schuckit MA
J Subst Abuse Treat 2009 Jan;36(1):S5-14

The genetic and molecular basis of Fanconi anemia
de Winter JP & Joenje H
Mutat Res 2008 Nov

Pharmacogenetic tests in asthma therapy
Yu IW & Bukaveckas BL
Clin Lab Med 2008 Dec;28(4):645-65

Pharmacogenetics-guided dose modifications of antidepressants
Seeringer A & Kirchheiner J
Clin Lab Med 2008 Dec;28(4):619-26

Pharmacogenetics in pain management: the clinical need
Webster LR
Clin Lab Med 2008 Dec;28(4):569-79

Pharmacogenomics of tamoxifen and irinotecan therapies
Algeciras-Schimnich A, et al.
Clin Lab Med 2008 Dec;28(4):553-67

 
 Genetic Testing

Subjective interpretation of inconclusive BRCA1/2 cancer genetic test results and transmission of information to the relatives
Cypowyj C, et al.
Psychooncology 2008 Dec

Common genetic, clinical, demographic and psychosocial predictors of response to  pharmacotherapy in mood and anxiety disorders
Serretti A, et al.
Int Clin Psychopharmacol 2008 Dec

Newborn screening for hemoglobinopathies in California
Michlitsch J, et al.
Pediatr Blood Cancer 2008 Dec

Changes in diet and physical activity following BRCA1/2 testing
O'Neill SC, et al.
J Psychosoc Oncol 2008;26(3):63-80

Practice Parameter: Evaluation of distal symmetric polyneuropathy: Role of laboratory and genetic testing (an evidence-based review). Report of the American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine,
England JD, et al.
Neurology 2008 Dec

 

 Genome Wide

Common variants at 30 loci contribute to polygenic dyslipidemia
Kathiresan S, et al.
Nat Genet 2008 Dec

A variant near MTNR1B is associated with increased fasting plasma glucose levels  and type 2 diabetes risk
Bouatia-Naji N, et al.
Nat Genet 2008 Dec

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Aulchenko YS, et al.
Nat Genet 2008 Dec

 

 HuGE

Clinical utility of five genetic variants for predicting prostate cancer risk and mortality
Salinas CA, et al.
Prostate 2008 Dec

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Page last updated: December 11, 2008 (archived document)
Content Source: National Office of Public Health Genomics