New article “Size matters: just how big is BIG? Quantifying realistic sample size requirements for human genome epidemiology”  (479KB) published in the August 2008 issue of the International Journal of Epidemiology. Authors: Paul R. Burton, Anna L. Hansell, Isabel Fortier, Teri A. Manolio, Muin J. Khoury, Julian Little and Paul Elliott.
	HuGENet™ What's New August 2008

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Genetic associations with schizophrenia: Meta-analyses of 12 candidate genes Shi J, et al. Schizophr Res 2008 Aug

Interethnic variability of plasma paraoxonase (PON1) activity towards organophosphates and PON1 polymorphisms among Asian populations--a short review
Mohamed Ali S & Chia SE
Ind Health 2008 Aug;46(4):309-17

Identification of low penetrance alleles for lung cancer: The GEnetic Lung CAncer Predisposition Study (GELCAPS)
Eisen T, et al.
BMC Cancer 2008 Aug;8(1):244

Genetic polymorphisms, the metabolism of estrogens and breast cancer: a review
Bugano DD, et al.
Eur J Gynaecol Oncol 2008;29(4):313-20

Individual genomes instead of race for personalized medicine
Ng PC, et al.
Clin Pharmacol Ther 2008 Sep;84(3):306-9

Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease
Dubois PC & van Heel DA
Clin Exp Immunol 2008 Aug;153(2):162-73

Clinical perspectives on hereditary hemochromatosis
Ayonrinde OT, et al.
Crit Rev Clin Lab Sci 2008;45(5):451-84

Newborn screening for cystic fibrosis: a lesson in public health disparities
Ross LF
J Pediatr 2008 Sep;153(3):308-13

Long-term outcome of presymptomatic testing in Huntington disease
Gargiulo M, et al.
Eur J Hum Genet 2008 Aug

Current Developments in the Genetics of Autism: From Phenome to Genome
Losh M, et al.
J Neuropathol Exp Neurol 2008 Aug

Pilot study of the breast cancer experiences of African American women with a family history of breast cancer: implications for nursing practice
Underwood SM, et al.
ABNF J 2008 Summer;19(3):107-13

Sudden Cardiac Arrest in Children and Young Athletes: The Importance of a Detailed Personal and Family History in the Pre-Participation Evaluation
Campbell RM, et al.
Br J Sports Med 2008 Aug

 

Irinotecan and uridine diphosphate glucuronosyltransferase 1A1 pharmacogenetics:  to test or not to test, that is the question
Deeken JF, et al.
Cancer 2008 Aug

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending August 27, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page