Centers for Disease Control and Prevention Centers for Disease Control and Prevention CDC Home Search CDC CDC Health Topics A-Z site search
National Office of Public Health Genomics
Centers for Disease Control and Prevention
Office of Genomics and Disease Prevention
Site Search
 
     
 Thursday, February 8, 2007     Volume 18   Number 6  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic research on disease prevention and public health. open mailbox for email deliveryGet email updates
Spotlight
view the current Update
image of heart and objects in cubes

February is American Heart Month
Heart disease is the leading cause of death in the United States and a major cause of disability.

Click here for more information.

CDC Announcements
back to top
bullhorn
HuGE What's New
February 2007
   
line
Genomics In The News
back to top
  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
light bulb
Featured item

“Grafts Against Cancer” This reference links to a non-governmental website
(Feb 3) Medial News Today reports, “A research team led by Prof. Claude Perreault, Université de Montréal, is announcing a major discovery in Genomics.”

“International consortium to get to heart of coronary artery disease” This reference links to a non-governmental website
(Feb 7) News-Medical.Net reports, “An international consortium has been launched to tackle coronary artery disease using the latest scientific tools.”

“Researchers identify 5 genetic variations associated with risk of venous thrombosis in
women”
 This reference links to a non-governmental website
(Feb 7) EurekAlert! reports, “Researchers have identified new genetic variations that may be associated with the risk of developing nonfatal venous thrombosis in postmenopausal women, according to a study in the February 7 issue of JAMA.”

“Human Proteins Evolving Slowly Thanks To Multitasking Genes” This reference links to a non-governmental website
(Feb 6) Science Daily reports, “Many human proteins are not as good as they might be because the gene sequences that code for them have a double role which slows down the rate at which they evolve, according to new research published in PLoS Biology.”

“Genes contributing to genetic disease ID'd” This reference links to a non-governmental website
(Feb 6) Science Daily reports, “U.S.-led scientists have identified two genes that contribute to Cornelia deLange syndrome, a genetic disease affecting about one in 10,000 children.”

“Simulating Human Metabolism” This reference links to a non-governmental website
(Feb 6) Biosearch Online reports, “Bioengineering researchers at UC San Diego have painstakingly assembled a virtual human metabolic network that will give researchers a new way to hunt for better treatments for hundreds of human metabolic disorders, from diabetes to high levels of cholesterol in the blood.”

“Gene Found For Rare Disorder May Reveal New Pathway In Mental Retardation” This reference links to a non-governmental website
(Feb 6) Medical News Today reports, “Studying mutations that give rise to a rare genetic disease, genetics researchers have identified a novel biological pathway that may have a broader role during human development, potentially in cases of mental retardation and autism.”

“OpenHelix Announces Free Trial Subscriptions to its Database of Tutorials on Genomics and Bioinformatics Resources” This reference links to a non-governmental website (last accessed 3/2007)
(Feb 5) hum-molgen.org reports, “OpenHelix announced today a program to give free access to researchers and scientists on its database of tutorial suites on genomic and bioinformatics resources.”

“Human genome study breakthrough reported” This reference links to a non-governmental website
(Feb 5) Earthimes.org reports, “U.S. cancer researchers say they have made a breakthrough in identifying functional elements in the human genome.”

“Gene linked to blood pressure” This reference links to a non-governmental website
(Feb 5) Earthimes.org reports, “University College London has demonstrated for the first time the structure and function of a gene crucial to the regulation of blood pressure.”

“Severe form of "enlarged prostate" discovered” This reference links to a non-governmental website
(Feb 5) News-Medical.Net reports, “Millions of middle-aged and older men experience the symptoms of an enlarged prostate multiple times during the day and night.”

“WHAT IS ALD?” This reference links to a non-governmental website
(Feb 5) The Mercury News reports, “Adrenoleukodystrophy (ALD) is one of a group of genetic disorders that cause damage to the myelin sheath, an insulating membrane that surrounds nerve cells in the brain.”

“Apolipoprotein E gene raises newborns' cerebral palsy risk” This reference links to a non-governmental website
(Feb 5) News-Medical.Net reports, “Apolipoprotein E (APOE), a gene associated with heightened risk for Alzheimer's disease in adults, can also increase the likelihood that brain-injured newborns will develop cerebral palsy, researchers at Children's Memorial Research Center have discovered.”

“Med BioGene announces futher promising results on the diagnostic value of its lymphoma genetic biomarkers” This reference links to a non-governmental website
(Feb 5) Bionity.com reports, “Med BioGene Inc. announced the results of its latest pre-clinical studies involving its Gene Expression Profiling System(TM) for diagnosing lymphoma.”

“Beyond the DNA: Chemical signatures reveal genetic switches in the genome” This reference links to a non-governmental website
(Feb 4) EurekAlert! reports, “Investigators from the Ludwig Institute for Cancer Research (LICR) and the University of California, San Diego (UCSD) School of Medicine have made a breakthrough in identifying functional elements in the human genome, according to a report published online today in Nature Genetics.”

“Gene research” This reference links to a non-governmental website
(Feb 2) Telegraph.co.uk reports, “A new study of the influenza strain that killed more people than the First World War underlines why the Government is taking the prospect of a bird flu pandemic seriously.”

“Study finds genetic link to women's heart disease” This reference links to a non-governmental website
(Feb 2) inside BayArea.com reports, “A certain gene variant may make women more susceptible to developing heart disease, researchers at Children's Hospital Oakland Research Institute reported Thursday.”

“Stanford-Led Study Closes in on Severe Depression Gene” This reference links to a non-governmental website
(Feb 1) GEN reports, “Stanford University researchers located a specific region on one chromosome they believe contributes to predisposition to severe depression.”

line
Genomics in Scientific Literature
back to top
light bulb
Featured item

Inference on haplotype/disease association using parent-affected-child data: the projection conditional on parental haplotypes method
Allen AS & Satten GA
Genet Epidemiol 2007 Jan

SNPassoc: an R package to perform whole genome association studies
Gonzalez JR, et al.
Bioinformatics 2007 Jan

Genetic variation of human adrenergic receptors: from molecular and functional properties to clinical and pharmacogenetic implications
Schaak S, et al.
Curr Top Med Chem 2007;7(2):217-31

Pharmacogenetics of antipsychotics: useful for the clinician?
Bondy B & Spellmann I
Curr Opin Psychiatry 2007 Mar;20(2):126-30

Living with Multiple Endocrine Neoplasia Type 1: Decent Care-Insufficient Medical and Genetic Information A Qualitative Study of MEN 1 Patients in a Swedish Hospital
Stromsvik N, et al.
J Genet Couns 2007 Feb

Increasing Utilization of Cancer Genetic Counseling Services Using a Patient Navigator Model
Rahm AK, et al.
J Genet Couns 2007 Feb

The Effect of Disruptions During Counseling on Recall of Genetic Risk Information: The Case of Cystic Fibrosis
Dillard JP, et al.
J Genet Couns 2007 Feb

Assessing the Informational Needs of Adolescents with a Genetic Condition: What Do They Want to Know?
Szybowska M, et al.
J Genet Couns 2007 Feb

Characterization of the Practice and Attitudes of Genetic Counselors with Doctoral Degrees
Atzinger CL, et al.
J Genet Couns 2007 Feb

Implications of conflicting definitions of probability to health risk communication: a case study of familial cancer and genetic counselling
C O'doherty K
Aust Health Rev 2007 Feb;31(1):24-33

Upward bias in odds ratio estimates from genome-wide association studies
Garner C
Genet Epidemiol 2007 Jan

A spatial probit model for fine-scale mapping of disease genes
De Iorio M & Verzilli CJ
Genet Epidemiol 2007 Jan

A partially linear tree-based regression model for assessing complex joint gene-gene and gene-environment effects
Chen J, et al.
Genet Epidemiol 2007 Jan

Pharmacogenomics of cancer chemotherapy-induced toxicity
Miller CR & McLeod HL
J Support Oncol 2007 Jan;5(1):9-14

Assessing Environmental Modifiers of Disease Risk Associated with Rare Mutations
Whittemore AS
Hum Hered 2007 Feb;63(2):134-43

Exploiting Gene-Environment Interaction to Detect Genetic Associations
Kraft P, et al.
Hum Hered 2007 Feb;63(2):111-9

The Impact of Genotype Misclassification Errors on the Power to Detect a Gene-Environment Interaction Using Cox Proportional Hazards Modeling
Tung L, et al.
Hum Hered 2007 Feb;63(2):101-10

The Use of the Restricted Partition Method with Case-Control Data
Culverhouse R
Hum Hered 2007 Feb;63(2):93-100

Strategy for Detecting Susceptibility Genes with Weak or No Marginal Effect
Kotti S, et al.
Hum Hered 2007 Feb;63(2):85-92

Detection of Gene x Gene Interactions in Genome-Wide Association Studies of Human Population Data
Musani SK, et al.
Hum Hered 2007 Feb;63(2):67-84

Risk Perception, Worry and Satisfaction Related to Genetic Counseling for Hereditary Cancer
Bjorvatn C, et al.
J Genet Couns 2007 Feb

Genomic diagnosis of thrombophilia in women: clinical relevance
Luxembourg B & Lindhoff-Last E
Hamostaseologie 2007;27(1):22-31

The Genetic Basis of Abdominal Aortic Aneurysms: A Review
Sandford RM, et al.
Eur J Vasc Endovasc Surg 2007 Feb

Application of nutrigenomic concepts to Type 2 diabetes mellitus
Kaput J, et al.
Nutr Metab Cardiovasc Dis 2007 Jan

Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: A complex genotype-phenotype relationship
Kraemer KH, et al.
Neuroscience 2007 Jan

Genetic susceptibility to obstructive sleep apnea in the obese child
Kalra M & Chakraborty R
Sleep Med 2007 Jan

Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions
Chung Y, et al.
Bioinformatics 2007 Jan;23(1):71-6

The impact of CYP allelic variation on antidepressant metabolism: a review
Black Iii JL, et al.
Expert Opin Drug Metab Toxicol 2007 Feb;3(1):21-31

Genetic polymorphisms of drug-metabolizing enzymes and the susceptibility to antituberculosis drug-induced liver injury
Huang YS
Expert Opin Drug Metab Toxicol 2007 Feb;3(1):1-8

Family History
back to top

“Want a fight? Scientists say it’s all in your genes” This reference links to a non-governmental website
(Feb 1) Times Online reports, “Scientists have found an answer to one of the most intractable squabbles in family life – argumentative and disruptive children are born, not made.”

Classification of missense variants of unknown significance in BRCA1 based on clinical and tumor information
Osorio A, et al.
Hum Mutat 2007 Feb

Risks for familial and contralateral breast cancer interact multiplicatively and cause a high risk
Hemminki K, et al.
Cancer Res 2007 Feb;67(3):868-70

Lack of aggregation of ischemic stroke subtypes within affected sibling pairs
Wiklund PG, et al.
Neurology 2007 Feb;68(6):427-31

Genetic Testing
back to top

“New test shows which breast cancers will recur” This reference links to a non-governmental website
(Feb 7) News-Medical.Net reports, “Approval has been granted by the FDA for a gene-based test that helps tell early-stage breast cancer patients whether they need chemotherapy after their surgery.”

“Expand prenatal gene tests, MDs urge” This reference links to a non-governmental website
(Feb 6) The Globe and Mail reports, “In an effort to identify more babies with disabilities before they are born, Canada's obstetricians and gynecologists are recommending that all pregnant women, regardless of their age, should undergo prenatal genetic screening if they choose.”

“Has Personalized Medicine Arrived?” This reference links to a non-governmental website
(Feb 2) Technology Review reports, “It may have arrived for real this month with a largely bureaucratic announcement by a government agency.”

“New Down's test eliminates miscarriage risk” This reference links to a non-governmental website (last accessed 3/2007)
(Feb 1) Reuters reports, “A new non-invasive test that examines fetal DNA can pick up genetic abnormalities such as Down's syndrome, researchers said on Friday.”

Retention and Use of Breast Cancer Recurrence Risk Information from Genomic Tests: The Role of Health Literacy
Lillie SE, et al.
Cancer Epidemiol Biomarkers Prev 2007 Jan

line
HuGE Published Literature
back to top

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending February 7, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Congenital Anomalies

For more information on HuGE, please visit the HuGENet™ home page

line
Upcoming Events
back to top

Click here for more information about upcoming events.

light bulb
Featured item

New This Week

Conference On The Medical Genetics With International Participation - Fetus – As A Part Of Family; SMA symposium, cystic fibrosis symposium 
you will need a free Acrobat reader to view this file (386KB) This reference links to a non-governmental website
May 22-24, 2007 ~ Kharkiv, Ukraine

How do we assess the contribution of complex genotypes and gene-environment interaction to the population burden of common diseases?
February 15, 2007 ~ Rockville, MD (ENVISION- Atlanta, GA)

   
New This Week

The 2nd World Congress on Gender-Specific Medicine This reference links to a non-governmental website
March 8-11, 2007 ~ Rome, Italy

   
New This Week

BIRD International Conference on Bioinformatics Research and Development This reference links to a non-governmental website
March 12-14, 2007 ~ Berlin, Germany

   
 

2007 Annual Clinical Genetics Meeting - American College of Medical Genetics  This reference links to a non-governmental website
March 21-25, 2007 ~ Nashville, Tennessee

line
 
Let's Go Surfing
back to top
light bulb
Featured item

FHS Offspring Cohort 100K Genome Scan This reference links to a non-governmental website
The GMED website displays the results from the first high-density (116,000 SNPs/individual) genome-wide scan of the Framingham Heart Study (FHS) Offspring Cohort. 1320 participants in the FHS Offspring Cohort were genotyped as part of this project. The overall goal of the project has been to identify common genetic variants that contribute to the heritability of medically relevant traits such as body mass index, fasting blood glucose, plasma cholesterol, QT-interval and hypertension among others.

Genetic Breast Cancer This reference links to a non-governmental website
A resource search engine on breast cancer links

Tutorial Suite for free This reference links to a non-governmental website
OpenHelix provides tutorials for free on genomic and bioinformatic resources

 

 

Send websites that you would like to see included in a future update to genetics@cdc.gov

To receive notification of this update by e-mail, please send the following message:
To: listserv@listserv.cdc.gov
Subject: (leave blank)
Message: subscribe genetics

The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: February 8, 2007 (archived document)
Content Source: National Office of Public Health Genomics