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 Thursday, April 5, 2007     Volume 18   Number 14  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic research on
disease prevention & public health.
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Spotlight
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April is National Autism Awareness Month
Autism is one of a group of developmental disorders known as autism spectrum disorders (ASDs). Scientists think that both genes and the environment play a role in ASDs. Family studies have been helpful in understanding how genes contribute to autism. Read more.

CDC Announcements
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HuGE What's New
April 2007
   
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New issue of Spotlight newsletter by the University of Washington Center for Genomics and Public Health
This issue highlights colorectal cancer awareness and the importance of screening for prevention and early detection of the disease. It also discusses risk factors, including lifestyle behaviors, family history, and genetics. Download PDF pdf icon (635KB)

   
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April seminar presented by CDC’s National Office of Public Health Genomics
Knowledge integration in public health genomics: evaluation of the epidemiologic evidence
April 19th, 2007, 1:00-3:00 p.m. ~ Rockville, MD (ENVISION - Atlanta)

   
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April issue of Hope Health Letter
The April issue of the Hope Health Letter features the article Know Your Past, Protect Your Future about the importance of family health history. This newsletter is produced by Hope Health, and helps to educate, motivate, and empower readers to take charge of their health. CDC’s National Office of Public Health Genomics has formed a partnership with Hope Health to provide readers information about family health history. For more information about the newsletter, please visit the Hope Health  This reference links to a non-governmental website website.

 
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CDC request for applications on Improving Public Health Practice through Translation Research (R18) (last accessed 2/2008)
The purpose of the RFA is the achievement of new scientific knowledge that can accelerate the translation of research findings into public health practice through implementation, dissemination, and diffusion research. Components are included from various CDC offices and centers. Genomics translation research priorities include family history, genetic testing, and genetics for early disease detection and intervention.
   
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Preparing for genetic testing”  This reference links to a non-governmental website
(Apr 3) United Press International reports, “Before looking into the genetic crystal ball for your future health prospects, the National Society of Genetic Counselors recommends you ask the following questions”

“Emerging genetic research may help scientists recognize children with autism at a younger
age”
 This reference links to a non-governmental website
(Apr 4) News-Medical.Net reports, “Emerging genetic research may help scientists recognize children with autism at a younger and potentially treatable age, according to an editorial in the April issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.”

“Gene behind autoimmune diseases identified by researchers”   This reference links to a non-governmental website
(Apr 2) Medical News Today reports, “A report in the March 22 issue of the New England Journal of Medicine reveals that a pinpointed region of chromosome 17, a gene named NALP1, could be a new target of treatment for autoimmune diseases.”

“Multiple genetic risk factors for prostate cancer found”   This reference links to a non-governmental website
(Apr 2) News-Medical.Net reports, “A study led by researchers at the Keck School of Medicine of the University of Southern California (USC) and Harvard Medical School has identified seven genetic risk factors DNA sequences carried by some people but not others that predict risk for prostate cancer.”

“Mutation in HNF4A associated with an increase in birthweight and macrosomia”   This reference links to a non-governmental website
(Apr 2) EurekAlert! reports, “A mutation in one gene HNF4A, associated with diabetes in the young, has been shown to be associated with an average increase in birthweight of 790g.”

“New genetic biomarkers could predict coronary heart disease”   This reference links to a non-governmental website
(Apr 2) Science Daily reports, “New genetic markers may be able to predict whether a person is likely to have coronary heart disease (CAD) in the future.”

“NIDA study identifies genes that might help some people abstain from smoking”   This reference links to a non-governmental website
(Apr 2) EurekAlert! reports, “Scientists supported by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, have for the first time identified genes that might increase a person’s ability to abstain from smoking.”

“People who are pre-diabetic or who have Type 2 diabetes have much shorter telomeres”   This reference links to a non-governmental website
(Apr 2) News-Medical.Net reports, “New genetic markers may be able to predict whether a person is likely to have coronary heart disease (CAD) in the future.”

“Brain tissue reveals possible genetic trigger for schizophrenia”   This reference links to a non-governmental website
(Apr 1) Medical News Today reports, “A study led by scientists from the University of North Carolina at Chapel Hill may have identified a molecular mechanism involved in the development of schizophrenia.”

“Gladstone scientists identify critical gene factor in heart development”   This reference links to a non-governmental website
(Apr 1) Medical News Today reports, “Researchers at the Gladstone Institute of Cardiovascular Disease (GICD) announced recently that they have identified a critical genetic factor in the control of many aspects of heart form and function.”

“Penn State scientists reveal structure of gateways to gene control”   This reference links to a non-governmental website
(Mar 31) News-Medical.Net reports, “Scientists at Penn State University will reveal in the journal Nature the first complete high-resolution map of important structures that control how genes are packaged and regulated throughout an entire genome.”

“New clues to gene expression in cystic fibrosis”   This reference links to a non-governmental website
(Mar 30) Science Daily reports, “Genetics tests could help provide cystic fibrosis (CF) patients with targeted treatment in future, pilot study authors suggest.”

“Child fights genetic disease”   This reference links to a non-governmental website
(Mar 29) Science Daily reports, “Kaitlyn Hart ran and squealed with joy, smiling and playing with a rubber ball like so many other 3-year-old girls.”

“Gene mutations linked to hereditary lung disease”   This reference links to a non-governmental website
(Mar 29) Science Daily reports, “Scientists at Johns Hopkins have identified the genetic culprits that trigger a hereditary form of a fatal lung disease.”

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Genomics in Scientific Literature
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Pooled Analysis and Meta-analysis of the Glutathione S-Transferase P1 Ile 105Val Polymorphism and Bladder Cancer: A HuGE-GSEC Review
Kellen E, et al.
Am J Epidemiol 2007 Apr

Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms
Holgate ST, et al.
Eur Respir J 2007 Apr;29(4):793-803

The role of genetic and environmental influences on heart rate variability in middle-aged men
Uusitalo AL, et al.
Am J Physiol Heart Circ Physiol 2007 Mar

Genetics of gestational diabetes mellitus
Shaat N & Groop L
Curr Med Chem 2007;14(5):569-83

Endocannabinoid system and CNR1 gene polymorphisms in schizophrenia and addictive disorders
Martinez-Gras I, et al.
Actas Esp Psiquiatr 2007 Mar-2007 Apr;35(2):122-9

The future of genomic nursing research
Conley YP & Tinkle MB
J Nurs Scholarsh 2007;39(1):17-24

Establishing the essential nursing competencies for genetics and genomics
Jenkins J & Calzone KA
J Nurs Scholarsh 2007;39(1):10-6

Communicating genetic information in families - a review of guidelines and position papers
Forrest LE, et al.
Eur J Hum Genet 2007 Mar

Human rights and ethics in genomic research: rethinking the model
Ashcroft RE
Pharmacogenomics 2007 Apr;8(4):391-5

Nutrigenomics: concepts and applications to pharmacogenomics and clinical medicine
Kaput J, et al.
Pharmacogenomics 2007 Apr;8(4):369-90

Polymorphisms in the CYP19 gene that influence bone mineral density
Riancho JA
Pharmacogenomics 2007 Apr;8(4):339-52

Gene-environment studies: any advantage over environmental studies?
Bermejo JL & Hemminki K
Carcinogenesis 2007 Mar

The FMR1 premutation and reproduction
Wittenberger MD, et al.
Fertil Steril 2007 Mar;87(3):456-65

Heritability of autistic traits in the general population
Hoekstra RA, et al.
Arch Pediatr Adolesc Med 2007 Apr;161(4):372-7

Family History
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 In The News

“Knowledge of relatives' health histories is helpful”   This reference links to a non-governmental website
(Mar 28) Our Midland.com reports, “Genealogists collect names and facts about ancestors, linking families together.”

 In The Scientific Literature

Building a bridge between clinical and basic research: the phenotypic elements of familial predisposition to type 1 diabetes
Matteucci E & Giampietro O
Curr Med Chem 2007;14(5):555-67

Screening Preferences of Patients at Familial Risk of Colorectal Cancer
Schroy Iii PC, et al.
Dig Dis Sci 2007 Apr

Family History of Diabetes, Awareness of Risk Factors, and Health Behaviors Among African Americans
Baptiste-Roberts K, et al.
Am J Public Health 2007 Mar

Genetic Testing
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 In The News

“NY hospitals agree to informed consent about genetic testing”   This reference links to a non-governmental website
(Apr 3) North Country Gazette reports, “The state Attorney General's office has reached new agreements with Columbia University Medical Center and New York-Presbyterian Hospital to ensure that patients can make educated decisions about genetic testing.”

“Philadelphia Inquirer examines efficacy of genetic testing to determine risk of breast cancer relapse”   This reference links to a non-governmental website
(Apr 3) News-Medical.Net reports, “Oncotype DX is one new tool that examines the DNA of a woman's tumor cells for mutations in 16 genes linked to breast cancer development.”

 

 In The Scientific Literature

Impact of pharmacogenomics on clinical practice in oncology
Marsh S
Mol Diagn Ther 2007;11(2):79-82

Information seeking and intentions to have genetic testing for hereditary cancers in rural and appalachian kentuckians
Kelly KM, et al.
J Rural Health 2007 Spring;23(2):166-72

Newborn screening: a literature review
Kayton A
Neonatal Netw 2007 Mar-2007 Apr;26(2):85-95

Psychosocial Impact of Genetic Testing for Hemochromatosis in The HEIRS Study: A Comparison of Participants Recruited in Canada And in The United States
Power TE, et al.
Genet Test 2007 Spring;11(1):55-64

Genomic health, inc
Baker J
Pharmacogenomics 2007 Apr;8(4):397-9

The Cost-Effectiveness of Expanding Newborn Screening for up to 21 Inherited Metabolic Disorders Using Tandem Mass Spectrometry: Results from a Decision-Analytic Model
Cipriano LE, et al.
Value Health 2007 Mar-2007 Apr;10(2):83-97

Genetic testing in colorectal cancer: who, when, how and why
Davidson NO
Keio J Med 2007 Mar;56(1):14-20

Population screening and cascade testing for carriers of SMA
Smith M, et al.
Eur J Hum Genet 2007 Mar

Testing And Reporting ACMG Cystic Fibrosis Mutation Panel Results
Lebo RV & Grody WW
Genet Test 2007 Spring;11(1):11-31

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending April 4, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Seminar Series of National Human Genome Research Institute, NIH
April 12, 2007 ~ Bethesda, MD

  EuroGP 2007- 10th European conference on Genetic Programming  This reference links to a non-governmental website
April 11-13, 2007 ~ Valencia, Spain
   
 

Microbial Genomes 2007  This reference links to a non-governmental website (last accessed 2/2008)
April 11-14, 2007 ~ Hinxton, UK

   

Epigenetics: Regulation of Chromatin Structure in Development and Disease   This reference links to a non-governmental website
April 11-16, 2007 ~ Breckenridge, CO

   
 

American Association for Cancer Research Annual Meeting 2007  This reference links to a non-governmental website (last accessed 2/2008)
April 14-18, 2007 ~ Los Angeles, CA

   
 

 Knowledge integration in public health genomics: evaluation of the epidemiologic evidence
 CDC's Public Health Genomics Monthly Seminar Series  
 April 19, 2007 ~ Rockville, MD (ENVISION - Atlanta, GA)

   
New Listing NCI Symposium on Chromosome Biology  This reference links to a non-governmental website
April 26-27, 2007 ~ Bethesda, MD
   
New Listing

Statistical Methods for Genetic Epidemiology  This reference links to a non-governmental website
May 7-11, 2007 ~ Edinburgh, UK


small triangle For a full listing of genetic and genomics-related events, please visit the 2007 Upcoming Events page.
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Let's Go Surfing
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Genetic Science Learning Center, University of Utah  This reference links to a non-governmental website
The Genetic Science Learning Center is an outreach education program located in the midst of bioscience research at the University of Utah. The mission of this center is to help people understand how genetics affects their lives and society.  

Genome  This reference links to a non-governmental website
This is an interactive website through the Dolan DNA Learning Center  This reference links to a non-governmental website that provides a tour of your genomes, and information about the Human Genome Project and genome mining

Personalized Medicine: Drugs designed for you  This reference links to a non-governmental website
This website is provided through the Genetic Science Learning Center This reference links to a non-governmental website at the University of Utah, and explains pharmacogenetics and pharmacogenomics, and their role in personalized medicine.

 

 

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: April 5, 2007 (archived document)
Content Source: National Office of Public Health Genomics