Population-based study of the prevalence of family history of cancer: Implications for cancer screening and prevention (169 KB)
Scott D. Ramsey et al.
Genet Med. 2006 Sep;8(9):571-575

Newborn Screening Translation Research Initiative
The mission of NSTRI is to assure that the translation of research methods into routine laboratory tests for newborn screening leads to sustainable high-quality testing and healthier babies worldwide

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.
  

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“Protein duo 'blocks cancer gene” (Sep 20) The Sidney Morning Herald reports, “Australian scientists have discovered a pair of proteins that team up to attack a notorious enzyme responsible for cancer.”

“Alzheimer's Symptoms May Arise From Mutant Genes”
(Sep 19) Health Scout reports, “Researchers at the University of Texas Southwestern Medical Center at Dallas and colleagues have been studying genes known as "presenilins," known to be mutated in people with an inherited form of Alzheimer's disease.”

“Gene variant may raise lung cancer risk from radon” (last accessed 3/2007)
(Sep 19) Reuters Health reports, “Gene variants that lead to decreased amounts of an enzyme known as GSTM1 may raise the risk of lung cancer related to radon exposure, new research suggests.”

“Nanocantilever biosensors detect multiple genes”
(Sep 19) News Medical.Net reports, “Using nanoscale cantilevers in a microfluidics device, a team of European researchers has developed a portable biosensor capable of detecting specific genetic sequences.”

“Genetic susceptibility in viral encephalitis”
(Sep 18) Medindia.com reports, “According to a study published in Science X-Press, an advanced, online edition of the journal Science on Sept. 14, a single gene immunodeficiency may cause susceptibility to herpes simplex virus.”

“Structure determined for key molecular complex involved in long-term gene storage”
(Sep 17) EurekAlert! reports, “Around the home, regularly used tools are generally kept close at hand: a can opener in a kitchen drawer, a broom in the hall closet. Less frequently used tools are more likely to be stored in less accessible locations, out of immediate reach, perhaps in the basement or garage.”

“UC Davis study finds distinct genetic profiles”
(Sep 14) EurekAlert! reports, “An international team of scientists lead by researchers at UC Davis Health System has found that, with respect to genetics, modern Europeans fall into two groups: a Northern group and a Southern, or Mediterranean one.”

“Genetic Discovery Allows Diabetic Girl to Swap Insulin Pump for Pill”
(Sep 14) RedOrbit reports, “When Lilly Jaffe, 6, gleefully disconnected her insulin pump from her hip last month, her mother, Laurie, forced herself to be brave.”

Role of BRCA1/2 mutations in pancreatic cancer
Greer JB & Whitcomb DC
Gut 2006 Sep

Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus
Forabosco P, et al.
Genes Immun 2006 Sep

Genetics and epidemiology of tourette syndrome
Keen-Kim D & Freimer NB
J Child Neurol 2006 Aug;21(8):665-71

Genetic, Ethnic, and GenderDifferences in the Pharmacokinetics of Antiretroviral Agents
Rotger M, et al.
Curr HIV/AIDS Rep 2006 Sep;3(3):118-25

Pharmacogenetics, drug-metabolizing enzymes, and clinical practice
Gardiner SJ & Begg EJ
Pharmacol Rev 2006 Sep;58(3):521-90

Pharmacogenetics of warfarin: current status and future challenges
Wadelius M & Pirmohamed M
Pharmacogenomics J 2006 Sep

Pharmacogenomics of colorectal cancer prevention and treatment
Nguyen H, et al.
Cancer Invest 2006 Sep;24(6):630-9

Diagnostic yield in the clinical genetic evaluation of autism spectrum disorders
Schaefer GB & Lutz RE
Genet Med 2006 Sep;8(9):549-56

Test of association between haplotypes and phenotypes in case-control studies: Examination of validity of the application of an algorithm for samples from cohort or clinical trials to case-control samples using simulated and real data
Furihata S, et al.
Genetics 2006 Sep

Genetic databases and pharmacogenetics: introduction
Ashcroft RE & Hedgecoe AM
Stud Hist Philos Biol Biomed Sci 2006 Sep;37(3):499-502

Candidate gene studies of attention-deficit/hyperactivity disorder
Faraone SV & Khan SA
J Clin Psychiatry 2006;67 Suppl 8:13-20

 Population-based study of the prevalence of family history of cancer: Implications for cancer screening and prevention
Ramsey SD, et al.
Genet Med 2006 Sep;8(9):571-5

Predictors of breast cancer development in a high-risk population
Chun J, et al.
Am J Surg 2006 Oct;192(4):474-7

“The mixed blessing of genetic choice” (last accessed 2/2008)
(Sep 19) The Manila Times reports, “The advance of knowledge is often a mixed blessing. Over the past 60 years, nuclear physics has been one obvious example of this truth. Over the next 60 years, genetics may be another.”

 “FTC warns consumers about at-home genetic tests”
(Sep 18) HeartCenterOnline reports, “Federal agencies want consumers to understand the facts about at-home genetic tests before choosing to use a product.”

“Single genetic assay could help physicians decide when to switch patients from Gleevec to
Sutent”
(Sep 14) EurekAlert! reports, “Researchers have found that the same gene mutation responsible for a tepid response to Gleevec (imatinib) in treatment of gastrointestinal stromal tumors (GIST), bestows benefit when a newer targeted therapy, Sutent (sunitinib), is used.”

“Human Genetic Testing Center Receives International Quality Accreditation in Germany”
(Sep 14) Yahoo reports, “IntegraGen, the personalized healthcare company focused on the development and commercialization of genetic tests for complex diseases, announced today that its German Competence Centre based in Bonn has received accreditation under ISO Standard 17025 for performing human genetic analyses.”

BRCA1/2 testing in hereditary breast and ovarian cancer families III: Risk perception and screening
McInerney-Leo A, et al.
Am J Med Genet A 2006 Sep

Advances in congenital long QT syndrome
Collins KK & Van Hare GF
Curr Opin Pediatr 2006 Oct;18(5):497-502

Low rates of acceptance of BRCA1 and BRCA2 test results among African American women at increased risk for hereditary breast-ovarian cancer
Halbert CH, et al.
Genet Med 2006 Sep;8(9):576-82

Exploring barriers to long-term follow-up in newborn screening programs
Hoff T, et al.
Genet Med 2006 Sep;8(9):563-70

Comprehensive genetic analysis of the cystic fibrosis transmembrane conductance regulatorfrom dried blood specimens - Implications for newborn screening
Kammesheidt A, et al.
Genet Med 2006 Sep;8(9):557-62

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending September 20, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

Table Browser
Use this program to get the data associated with a track in text format, to calculate intersections between tracks, and to retrieve DNA sequence covered by a track.

Request for Information (RFI): Proposed Policy for Sharing of Data obtained in NIH supported or conducted Genome-Wide Association Studies (GWAS)
The NIH is seeking comments regarding a proposed policy for NIH supported or conducted Genome-Wide Association Studies (GWAS).