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 Thursday, June 15, 2006     Volume 16   Number 24  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
Spotlight
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Obesity and Genetics: A Public Health Perspective (PHP)
This updated PHP examines obesity as it relates to genes and the environment and includes helpful resources for a healthy weight, journal articles, and presentations.

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CDC Announcements
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CDC sponsored material

New HuGE Case Studies

   
CDC sponsored material HuGE What's New
June 2006
   
CDC sponsored material

New HuGE Review
Factor XIII Val34Leu Variant Is Protective against Venous Thromboembolism: A HuGE Review and Meta-Analysis you will need a Free Acrobat reader to view this file(169KB)
Philip S. Wells et al.  American Journal of Epidemiology (June 2006)

   
CDC sponsored material New HuGE Review
XRCC3 and XPD/ERCC2 Single Nucleotide Polymorphisms and the Risk of Canceryou will need a Free Acrobat reader to view this file (3.0MB / Web tables included)
Maurizio Manuguerra et al. Genetics in Medicine (April 2006)
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles. 
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“Too Much Information” This reference links to a non-governmental website 
(June13) Washingtonpost.com reports, “Imagine being able to order a genetic test over the Internet -- to see if you have inherited a predisposition to cancer or whether there might be a genetic component to your infertility -- without having to get approval from your doctor, consult a genetic counselor or risk the fallout that might result from filing an insurance claim.”

“Gene Variation Affects Asthma Drug Treatment” This reference links to a non-governmental website 
(June15) Medical News Today reports, “Researchers at the University of Dundee have discovered that a significant proportion of young asthmatics may not benefit from a commonly used asthma medicine known as salmeterol, due to a gene variation which is present in around 13% of the population.”

“NIH Encourages African Americans to Make Health A 'Family Reunion' Affair”
(June13) NIH reports, “As African-American families across the country plan their reunions this summer, the National Kidney Disease Education Program (NKDEP), an initiative of the National Institutes of Health, is encouraging them to talk about several health issues that disproportionately affect African Americans — diabetes, high blood pressure, and kidney disease.”

“Gene called "Nanog" could be key to master cells”
(June14) Reuters Health reports, “A gene named after the mythical Celtic land of the ever young could help explain how to reprogramme adult cells into embryonic stem cells to treat diseases, researchers at the University of Edinburgh reported Wednesday.”

“Scientists watch the behavior of a single gene in real time” This reference links to a non-governmental website 
(June14) News-Medical.net reports, “Scientists at the Albert Einstein College of Medicine of Yeshiva University have observed for the first time that gene expression can occur in the form of discrete "pulses" of gene activity.”

“Gene Expression In Labor; And More -- Press Release From PLoS Medicine” This reference links to a non-governmental website 
(June14) Medical News Today reports, “A Research Article, Perspective and e-Letter all published today discuss the use of microarrays to discover genes involved in childbirth.”

“Gene research hope to ease brittle bone pain for men” This reference links to a non-governmental website 
(June13) News.scotsman.com reports, “Scientists in Edinburgh are set to carry out groundbreaking genetic research into the soaring number of men suffering from the crippling bone condition osteoporosis.”

“Two Seville Doctors Discover The Gene That Causes The Hereditary Cushing's Syndrome” This reference links to a non-governmental website 
(June13) Medical News Today reports, “Two Seville-based scientists of the Molecular Genetics Laboratory of Virgen Macarena Hospital have discovered the gene responsible for the hereditary Cushing's syndrome, a disease that is the result of an increase of the blood cortisol level, a hormone produced by the adrenal glands.”

“Activation of microRNA inhibits cancer gene in human cancer cells” This reference links to a non-governmental website 
(June12) EurekAlert! reports, “Scientists report that tumor cells display a dramatic reduction of cancer-causing genes when a newly discovered method is used to activate the expression of protective microRNAs in the cancer cell genome.”

“Single copy of Parkinson's-risk gene mutation may lead to earlier symptom onset” This reference links to a non-governmental website 
(June12) EurekAlert! reports, “Mutations in a gene already known to play a role in causing an inherited form of Parkinson disease may also influence the age at which symptoms of the neurological disorder appear.”

“Gene Test May Show Who Can Skip Chemo” This reference links to a non-governmental website (last accessed 2/2008)
(June12) USA Today reports, “Claudia Lowry had a scary decision: Could she safely skip chemotherapy after surgeons removed her breast cancer?”

“Scientists tie several cancers to common 'oncogene engine'” This reference links to a non-governmental website 
(June12) EurekAlert! reports, “Researchers at Dana-Farber Cancer Institute report that a common "oncogene engine" – a small family of malfunctioning cell growth switches – drives several seemingly unrelated, lethal forms of cancer, including malignant melanoma. The finding suggests that it may be possible to attack these different cancers with the same therapy.”

“Speeding the search for elusive chromosomal errors” This reference links to a non-governmental website 
(June12) EurekAlert! reports, “A pediatric research team has used commercially available gene chips to scrutinize all of a patient's chromosomes to identify small defects that cause genetic diseases.”

“3 new cataract causing genes found”
(June12) Zeenews.com reports, “Geneticists at the Centre for Genetic Disorders of Guru Nanak Dev University (GNDU) have identified three genes that lead to cataract among the Indian population.”

“Lack of key enzyme associated with development of rare tumor” This reference links to a non-governmental website 
(June11) EurekAlert! reports, “Researchers at the National Institutes of Health have discovered that a rare tumor of the adrenal glands appears to result from a genetic deficiency of an important enzyme.”

“Discovery of SLIRP gene could lead to cancer breakthroughs” This reference links to a non-governmental website 
(June 9) News-Medical.Net reports, “Western Australian researchers have discovered a new gene that could lead to breakthroughs in breast and prostate cancer, as well as diabetes.”

“Danes find the asthma gene” This reference links to a non-governmental website 
(June 9) The Copenhagen Post reports, “A Danish team of scientists has found the gene responsible for the development of asthma.”

“Protein From The Wrong Side Of The Tracks Aids Cancer Virus” This reference links to a non-governmental website 
(June 8) Research News reports, “A protein made by a cancer-causing virus using an unusual gene enables that virus to infect immune cells and persist in the host, new research shows.”

“New step toward treatment for Duchenne muscular dystrophy” This reference links to a non-governmental website 
(June 8) EurekAlert! reports, “The team led by Dr. Jacques P. Tremblay, a researcher with the Human Genetics Department at Quebec City's Centre Hospitalier Universitaire de Québec (CHUQ) and professor with Université Laval's Faculty of Medicine, has taken an important step toward a cure for Duchenne muscular dystrophy.”
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Genomics in Scientific Literature
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Genetics and genomics nursing: scope and standards of practice
Greco KE
Nurs Health Sci 2006 Jun;8(2):125
**View associated articles below

Exploring Genetic Counseling Communication Patterns: The Role of Teaching and Counseling Approaches
Ellington L, et al.
J Genet Couns 2006 Jun

Is Self-Disclosure Part of the Genetic Counselor's Clinical Role?
Thomas BC, et al.
J Genet Couns 2006 Jun

Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease)
Roses AD, et al.
Pharmacogenomics J 2006 Jun

Family history of inflammatory bowel disease in patients with idiopathic ocular inflammation
Lin P, et al.
Am J Ophthalmol 2006 Jun;141(6):1097-104

Genetic Issues in Pediatric Pancreatitis
Kandula L, et al.
Curr Gastroenterol Rep 2006 Jun;8(3):246-51

Using Family History to Assess Women's Cancer Risk in a Parish Nurse Setting
Cherry C
Nurs Health Sci 2006 Jun;8(2):129

Sharing Information with Children about Their Genetic Conditions
Gallo A, et al.
Nurs Health Sci 2006 Jun;8(2):128

Concerns of Young Women Who are Positive for Brca1 and/or Brca2
Hamilton R
Nurs Health Sci 2006 Jun;8(2):127

A pioneer nursing genomics staff development program
Pestka E, et al.
Nurs Health Sci 2006 Jun;8(2):127

Smokers' Perceptions about Genetic Contributions to Smoking
Houfek JF, et al.
Nurs Health Sci 2006 Jun;8(2):126

Statewide cancer genomics integration in Michigan
Zenger-Hain J, et al.
Nurs Health Sci 2006 Jun;8(2):126

Demystifying online genetic databases
Driscoll C, et al.
Nurs Health Sci 2006 Jun;8(2):125

Genetics of osteoporosis
Huang QY & Kung AW
Mol Genet Metab 2006 Jun

Protocol for Stage 1 of the GaP Study (Genetic Testing Acceptability for Pagets Disease of Bone): An Interview Study about Genetic Testing and Preventive Treatment: Would relatives of people with Pagets disease want testing and treatment if they were avai
Langston AL, et al.
BMC Health Serv Res 2006 Jun;6(1):71

BRCA1 and BRCA2 genetic testing in Italian breast and/or ovarian cancer families: mutation spectrum and prevalence and analysis of mutation prediction models
Capalbo C, et al.
Ann Oncol 2006 Jun;17 Suppl 7:vii34-vii40

Resources for Genetic Variation Studies
Serre D & Hudson TJ
Annu Rev Genomics Hum Genet 2006 Jun

   
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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending June 14, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Certain Conditions Originating in the Perinatal Period
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New this week Neurodegenerative Diseases: Molecular Mechanisms in a Functional Genomics Framework This reference links to a non-governmental website 
September 6-9, 2006 ~ Berlin, Germany
 

2006 Genetic Alliance Conference: Celebrating 20 years of Excellence in Advocacy This reference links to a non-governmental website 
July 28-30, 2006 ~ Bethesda, MD

   
  11th International Congress of Human Genetics This reference links to a non-governmental website 
August 6-10, 2006 ~ Brisbane, Australia
   
New this week Aging Research in Immunology
September 4-5, 2006 ~ Paris, France
   
  From Genomes to Protective Antigens – Designing Vaccines This reference links to a non-governmental website 
November 15-17, 2006 ~ Prague, Czech Republic
   
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Let's Go Surfing
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Public Health Genetics Unit, UK, Newsletter, June 2006 This reference links to a non-governmental website 
The Public Health Genetics Unit (PHGU) of the United Kingdom (UK) aims to keep abreast of developments in molecular and clinical genetics, and in their ethical, legal, social and public health implications.

Famous DNA This reference links to a non-governmental website 
DNA Haplotypes (DNA signatures) for famous, or infamous, homo sapiens

SOURCE This reference links to a non-governmental website 
“Developed by the Genetic Department of Stanford University, SOURCE is a unification tool which dynamically collects and compiles data from many scientific databases, and thereby attempts to encapsulate the genetics and molecular biology of genes from the genomes of Homo sapiens, Mus musculus, Rattus norvegicus into easy to navigate GeneReports.”

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: June 15, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics