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 Thursday, June 1, 2006     Volume 16   Number 22  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
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HuGE Published Literature Database
The HuGE Published Literature Database (HuGE Pub Lit) is a searchable, online knowledge base of published, population-based epidemiologic studies of human genes. The database contains links to PubMed articles and can be searched by gene, disease, interacting factor, type of study design or analysis, or any combination of terms in these categories. Read the scientific article in the American Journal of Epidemiology that provides an overview of the database.

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CDC Announcements
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CDC's 2006 National Health Promotion Conference
September 12-14, 2006 ~ Atlanta, GA
A joint conference presented by CDC’s Coordinating Center for Health Promotion (CoCHP) as related to birth defects and developmental disabilities, chronic disease, and genomics. Registration is now open.

   
CDC sponsored material

New HuGE Review
Factor XIII Val34Leu Variant Is Protective against Venous Thromboembolism: A HuGE Review and Meta-Analysis you will need a free Acrobat reader to view this file(169KB)
Philip S. Wells et al.  American Journal of Epidemiology (June 2006)

   
CDC sponsored material New HuGE Review
XRCC3 and XPD/ERCC2 Single Nucleotide Polymorphisms and the Risk of Cancer you will need a free Acrobat reader to view this file (3.0MB / Web tables included)
Maurizio Manuguerra et al. Genetics in Medicine (April 2006)
   
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Integrating the Evidence on Gene-Disease Association:Methods and applications of HuGE systematic reviewsThis reference links to a non-governmental website 
November 6-8, 2006 ~ Cambridge, UK
Apply now, space is limited.
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Mayo Clinic Studies Find Association Between Acid Reflux And Esophageal Cancer”This reference links to a non-governmental website
(May 31) Science Daily reports, “Two new Mayo Clinic studies draw attention to the risk factors and possible genetic basis for Barrett's esophagus and esophageal cancer (adenocarcinoma).”

“The New Algorithm Analysizes Gene Chips To Detect Certain Cancer Genes”This reference links to a non-governmental website
(June 1) New Materials International reports, “Researchers at New York University's Courant Institute of Mathematical Sciences have developed a new algorithm that makes it much easier to detect certain cancer genes, and as a test, have applied it to map a set of tumor-suppressor genes involved in lung cancer.”

“Jefferson Scientists Identify Gene Mutation Potentially Involved in Breast Cancer Initiation”This reference links to a non-governmental website
(May 31) Thomas Jefferson University Hospital reports, “Researchers at Jefferson Medical College and the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia and at the Albert Einstein College of Medicine in New York have found evidence suggesting that a mutation in a gene that normally helps block the formation of breast tumors could play a role in the initiation of a major form of breast cancer.”

“Overcoming A Genetic Defect”This reference links to a non-governmental website
(May 31) Medical News Today reports, “The European Union has approved a grant of about € 2.4 million to a team of European scientists, led by the Kiel biochemist Professor Paul Saftig, to carry out research on the rare hereditary disease alpha-mannosidosis.”

“Blood Compatibility - It's All In The Genes!”This reference links to a non-governmental website
(May 30) Medical News Today reports, “In most developed countries safe blood transfusion is taken for granted. But blood grouping is a complex business, and not all blood groups are compatible.”

“Genetic disorder could cause strokes”This reference links to a non-governmental website
(May 30) WebIndia123.com reports, “A rare genetic disorder may be responsible for causing strokes in young people, though the condition''s progress can be slowed using enzyme replacement treatment, says a study.”

“Research Suggests Cause Of Neurodegeneration In Huntington's Disease”This reference links to a non-governmental website
(May 30) Science Daily reports, “The severe neurodegeneration associated with Huntington's disease may result from molecular mutations that block the transport of nutrients within cells.”

“RNA Interference Genetic Screen Suggests New Targets for Cancer Therapies”This reference links to a non-governmental website
(May 29) National Cancer Institute reports, “Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, have developed a new method to identify genes that keep cancer cells active and that could be potential targets of anticancer therapies.”

“RNA Interference Gene Therapy Takes Two Steps Forward, One Step Back” This reference links to a non-governmental website
(May 28) Science Daily reports, “Three years ago Mark Kay, MD, PhD, published the first results showing that a hot new biological phenomenon called RNA interference was an effective gene-therapy technique in mice.”

“New pathways for autoimmune treatment identified” This reference links to a non-governmental website (last accessed 2/2008)
(May 28) Medical News Today reports, “A rare genetic defect that can trigger a host of diseases from type 1 diabetes to alopecia has helped explain the imbalance of immune regulator and killer cells in autoimmune disease.”

“Nobel Laureate Nüsslein-Volhard To Discuss Mysteries Of Genetics” This reference links to a non-governmental website
(May 28) Medical News Today reports, “Why do children look like their parents? How does an embryonic cell know how to become an eye rather than an eyelash? How do simple egg cells develop into so many different life forms?”

“Researchers Identify Genetic Defects That Cause Main Types Of Non-Hodgkin Lymphoma, Paving The Way For Potential New Targeted Therapies” This reference links to a non-governmental website
(May 27) Medical News Today reports, “Researchers will report on the discovery of genetic defects that cause particular types of non-Hodgkin lymphoma (NHL), making these genes rational targets for new anti-lymphoma treatments, in the next issue of Blood.”

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Genomics in Scientific Literature
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Genetics as a tool to improve cancer outcomes: ethics and policy
Burke W & Press N
Nat Rev Cancer 2006 Jun;6(6):476-82

Genetics of autism spectrum disorder
Klauck SM
Eur J Hum Genet 2006 Jun;14(6):714-20

Molecular genetic studies of schizophrenia
Riley B & Kendler KS
Eur J Hum Genet 2006 Jun;14(6):669-80

Genetics of affective (mood) disorders
Craddock N & Forty L
Eur J Hum Genet 2006 Jun;14(6):660-8

The human cytochrome P450 Allele Nomenclature Committee website: submission criteria, procedures, and objectives
Sim SC & Ingelman-Sundberg M
Methods Mol Biol 2006;320:183-91

Toward evidence-based assessment for coverage and reimbursement of laboratory-based diagnostic and genetic tests
Ramsey SD, et al.
Am J Manag Care 2006 Apr;12(4):197-202

Ethical, social and legal implications of genetic testing in liver disease
van Leeuwen DJ & Bernat JL
Hepatology 2006 May;43(6):1195-201

HLA and Leprosy in the Pre and Postgenomic Eras
Geluk A & Ottenhoff TH
Hum Immunol 2006 Jun;67(6):439-45

Acceptance of Preventive Surgeries by Israeli Women Who had Undergone BRCA Testing
Kram V, et al.
Fam Cancer 2006 May

Power and sample size calculations in the presence of phenotype errors for case/control genetic association studies
Edwards BJ, et al.
BMC Genet 2005;6(1):18

The future prospects of pharmacogenetics in oral anticoagulation therapy
Kamali F & Pirmohamed M
Br J Clin Pharmacol 2006 Jun;61(6):746-51

Human genetics and pharmacology of neurotransmitter transporters
Lin Z & Madras BK
Handb Exp Pharmacol 2006(175):327-71

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending May 31, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New this week The Fifth International Conference on Bioinformatics of Genome Regulation and Structure (BGRS'2006) This reference links to a non-governmental website
July 16-22, 2006 ~ Novosibirsk, Russia
New this week

The Human Variome Project Meeting- International Collection of Human Gene VariationThis reference links to a non-governmental website
June 20-23, 2006 ~ Melbourne, Australia

   
New this week 47th Annual Short Course on Medical and Experimental Mammalian Genetics
July 16-28, 2006 ~ Bar Harbor, Maine
   
New this week 6th Australasian Workshop on Mutation Detection - Methods, Cancer Gene Analysis & Diagnostic ApplicationsThis reference links to a non-governmental website
August 2-5, 2006 ~ South Stradbroke Island, Australia
   
New this week The Second International Human ES Cell Workshop
August 3-6, 2006 ~ Bar Harbor, Maine
   
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Let's Go Surfing
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From the Human Genome Through Health Disparities to Public Health This reference links to a non-governmental website
A videotaped presentation from the Public Health Roundtable held at the University of Minnesota.

Understanding Genetics: A Guide for Patients and Health ProfessionalsThis reference links to a non-governmental website
This comprehensive manual provides a wealth of genetic education materials for patients and health professionals to increase awareness of specialty care in genetics.

The Mentor NetworkThis reference links to a non-governmental website
Provides as in-depth and personal learning opportunities for students and is sponsored by The American Society of Human Genetics, The National Human Genome Research Institute, The Genetic Alliance, National Society for Genetic Counselors, and the Genetics Society of America Mentorship Program.

HUGO Gene Nomenclature CommitteeThis reference links to a non-governmental website (last accessed 2/2008)
The Committee has approved over 23,000 symbols which are stored in the HGNC database.

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
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This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: June 1, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics