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 Thursday, July 6, 2006     Volume 17   Number 1  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
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Genetic testing for susceptibility to breast and ovarian cancer: Evaluating the impact of a direct-to-consumer marketing campaign on physicians’ knowledge and practices (2006)
Melanie F. Myers, et al.
Genetics in Medicine;8(6):361-370.

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CDC Announcements
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CDC sponsored material

Obesity and Genetics: A Public Health Perspective (PHP)
This updated PHP examines obesity as it relates to genes and the environment and includes helpful resources for a healthy weight, journal articles, and presentations.

   
CDC sponsored material Storage and use of residual dried blood spots from state newborn screening programs
Olney RS, et al.
J Pediatr 2006 May;148(5):618-22
   
CDC sponsored material

New HuGE Case Studies

CDC sponsored material HuGE What's New
July 2006
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Scientists Identify an Inherited Gene That Strongly Affects Risk for the Most Common Form of Melanoma” This reference links to a non-governmental website
(June 30) National Cancer Institute reports, “Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, have identified a link between inherited and acquired genetic factors that dramatically increase the chance of developing a very common type of melanoma.”

“Illicit Drug Use And Abuse May Be Genetic”  This reference links to a non-governmental website
(July 5) VCU News reports, “Researchers have found that genetic factors may play an important role in a person’s use, misuse or dependence of illicit drugs like marijuana, stimulants, opiates, cocaine and psychedelics.”

“Variations in detoxifying genes linked to Lou Gehrig's disease”  This reference links to a non-governmental website
(July 5) EurekAlert! reports, “Genetic variations in three enzymes that detoxify insecticides and nerve gas agents as well as metabolize cholesterol-lowering statin drugs may be a risk factor for developing sporadic amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease), and possibly responsible for a reported twofold increased risk of ALS in Gulf War veterans.”

“Genetic link found to noise-induced hearing loss”  This reference links to a non-governmental website (last accessed 3/2007)
(July 5) Reuters Health via deafness research uk reports, “Belgian scientists have pinpointed three genes that may explain why some people exposed to loud noise suffer hearing loss.”

“Scientists identify overactive protein that plays a key role in cystic fibrosis”  This reference links to a non-governmental website
(July 5) News-Medical.net reports, “A team led by Johns Hopkins Children's Center scientists has identified and successfully tamed an overactive protein that plays a key role in cystic fibrosis (CF), a genetic disorder that interferes with the body's ability to transport chloride in and out of cells.”

“Monitoring genetic counseling” 
(July 5) Daily News Tribune reports, “Genetic counselors would have to obtain licenses to practice in Massachusetts under pending legislation that also gives state regulators authority to discipline counselors who specialize in this emerging medical field.”

“Dawn of home genetic testing offers promise and controversy” This reference links to a non-governmental website
(July 4) The Charlotte Observer reports, “You no longer need a doctor or genetic counselor to test your risk of developing certain diseases that run in families, such as breast cancer or Alzheimer's.”

“Sleep gene discovery” This reference links to a non-governmental website
(July 4) News-Medical.net reports, “Proteins that regulate sleep and biological timing in the body work much differently than previously thought, meaning drug makers must change their approach to making drugs for sleep disorders and depression and other timing-related illnesses.”

“New diagnostic approach for carriers of recessive genetic disorders” This reference links to a non-governmental website
(July 3) News-Medical.net reports, “Scientists Vivian Cheung and Warren Ewens from the University of Pennsylvania have developed a new approach for the diagnosis of medical disorders that are inherited in a recessive manner.”

“Researchers develop T-cells from human embryonic stem cells” This reference links to a non-governmental website
(July 3) News-Medical.net reports, “Researchers from the UCLA AIDS Institute and the Institute for Stem Cell Biology and Medicine have demonstrated for the first time that human embryonic stem cells can be genetically manipulated and coaxed to develop into mature T-cells, raising hopes for a gene therapy to combat AIDS.”

“New class of experimental drug that targets master regulator gene called c-Jun” This reference links to a non-governmental website
(July 3) News-Medical.net reports, “University of New South Wales (UNSW) researchers have announced they are developing a new class of experimental drug that has the potential to treat a diverse range of health problems, from inflammation and cancer through to eye and heart disease.”

“Genetic parallels found between lung development and lung cancer” This reference links to a non-governmental website
(July 3) EurekAlert! reports, “For over 100 years, biologists have speculated that cancer growth shares common features with embryonic development.”

“Novel gene therapy may lead to cure in hemophilia A patients” This reference links to a non-governmental website
(July 3) EurekAlert! reports, “A discovery by Medical College of Wisconsin and BloodCenter of Wisconsin researchers in Milwaukee may be a key to a permanent genetic cure for hemophilia A patients, including a subset who do not respond to conventional blood transfusions.”

“Lexicon Genetics Files Application For LX6171 Phase 1 Trial For Cognitive Disorders” This reference links to a non-governmental website
(June 30) Medical News Today reports, “Lexicon Genetics Incorporated (Nasdaq: LEXG) announced today that it has submitted a Clinical Trial Authorization (CTA) filing to the United Kingdom Medicines and Healthcare Products Regulatory Agency (MHRA) for LX6171, an internally- developed small molecule compound for cognitive disorders.”

“Johns Hopkins Lab Scientists Tame Overactive Cf Protein” This reference links to a non-governmental website
(June 29) Johns Hopkins Medicine reports, “A team led by Johns Hopkins Children’s Center scientists has identified and successfully tamed an overactive protein that plays a key role in cystic fibrosis (CF), a genetic disorder that interferes with the body’s ability to transport chloride in and out of cells.”

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Genomics in Scientific Literature
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Family History, and Impact on Clinical Presentation and Prognosis, in a Population-based Breast Cancer Cohort from the Stockholm County
Margolin S, et al.
Fam Cancer 2006 Jul

Role of CYP pharmacogenetics and drug-drug interactions in the efficacy and safety of atypical and other antipsychotic agents
Murray M
J Pharm Pharmacol 2006 Jul;58(7):871-85

The genetics of neurodegenerative diseases
Hardy J & Orr H
J Neurochem 2006 Jun;97(6):1690-9

Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer
Giovannetti E, et al.
Mol Cancer Ther 2006 Jun;5(6):1387-95

Genetics of obesity
O'rahilly S & Farooqi IS
Philos Trans R Soc Lond B Biol Sci 2006 Jul;361(1471):1095-105

TPMT, UGT1A1 and DPYD: genotyping to ensure safer cancer therapy?
Maitland ML, et al.
Trends Pharmacol Sci 2006 Jun

Nutrigenetics, plasma lipids, and cardiovascular risk
Ordovas JM
J Am Diet Assoc 2006 Jul;106(7):1074-81

Breast cancer as a second primary in patients with prostate cancer-estrogen treatment or association with family history of cancer?
Karlsson CT, et al.
J Urol 2006 Aug;176(2):538-43

Genetic and Cultural Transmission of Smoking Initiation: An Extended Twin Kinship Model
Maes HH, et al.
Behav Genet 2006 Jun

Genetic diagnosis and testing in clinical practice
McPherson E
Clin Med Res 2006 Jun;4(2):123-9

Attitudes of urban American Indians and Alaska Natives regarding participation in research
Buchwald D, et al.
J Gen Intern Med 2006 Jun;21(6):648-51

Pharmacogenomics: Catechol O-Methyltransferase to Thiopurine S-Methyltransferase
Weinshilboum RM
Cell Mol Neurobiol 2006 Jun

Single gene disorders causing ischaemic stroke
Razvi SS & Bone I
J Neurol 2006 Jun;253(6):685-700

Direct-to-patient BRCA1 testing: the Twoj Styl experience
Gronwald J, et al.
Breast Cancer Res Treat 2006 Jun

Genetic causes of male infertility
Ferlin A, et al.
Reprod Toxicol 2006 Jun

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending July 5, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New This Week

Genomics Momentum 2006
November 9, 2006 ~ Rotterdam, Netherlands

New This Week

Quality Assurance Program for Cystic Fibrosis: IRT and DNA The Good and The Baaaaad
July 11, 2006 ~ Atlanta, GA

   
  5th European Congress of Biogerontology This reference links to a non-governmental website
September 16-20, 2006 ~ Istanbul, Turkey
   
New This Week 15th Annual Meeting of the Australasian Epidemiological Association This reference links to a non-governmental website
September 18-19, 2006 ~ Melbourne, Australia
   
New This Week Cardiofaciocutaneous Syndrome and Noonan Syndrome This reference links to a non-governmental website
November 17-19, 2006 ~ Potomac, Maryland
   
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Let's Go Surfing
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Genetics Society of America This reference links to a non-governmental website
The Society promotes the communication of advances in genetics through publication of the journal GENETICS, and by sponsoring scientific meetings focused on key organisms widely used in genetic research.

Center for Genetics and Genomics This reference links to a non-governmental website
Harvard Medical School

Human Genetics Center This reference links to a non-governmental website (last accessed 1/2008)
The University of Texas-Houston

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: July 6, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics