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 Thursday, January 26, 2006     Volume 16   Number 4  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
Spotlight
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Nature Genetics article: A road map for efficient & reliable human genome epidemiology

A road map for efficient and reliable human genome epidemiology This reference links to a non-governmental website
John P A Ioannidis, Marta Gwinn, Julian Little, et al.
Nature Genetics 38, 305 (2006)
“Networks of investigators have begun sharing best practices, tools and methods for analysis of associations between genetic variation and common diseases. A Network of Investigator Networks has been set up to drive the process……”

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CDC Announcements
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CDC’s National Health Promotion Conference - Save the Date
September 12-14, 2006 ~ Atlanta, GA
The 2006 National Health Promotion Conference is the first joint conference presented by CDC’s Coordinating Center for Health Promotion (CoCHP) and its constituent groups: the National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), the National Center on Birth Defects and Developmental Disabilities (NCBDDD), and the Office of Genomics and Disease Prevention (OGDP).
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EPHX1 Polymorphisms and the Risk of Lung Cancer
Chikako Kiyohara, et al.

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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“The Personal Genome Project” This reference links to a non-governmental website
(January 19) Technology Review reports, “Church and collaborators plan to build a database that will integrate individual genomes, medical histories and other information about each participant, enabling scientists to do more comprehensive genetic research -- and help advance the field of personalized medicine.”

“Researchers identify gene mutation as major cause of Parkinson's in Ashkenazi Jewish patients” This reference links to a non-governmental website
(January 25) EurekAlert! reports, “Researchers at the Albert Einstein College of Medicine of Yeshiva University and its Manhattan hospital affiliate, Beth Israel Medical Center, have found that a specific mutation in a single gene is a major cause of Parkinson's disease among Ashkenazi (Eastern European) Jews.”

“UW scientists unravel critical genetic puzzle for flu virus replication” This reference links to a non-governmental website
(January 25) EurekAlert! reports, “Like any other organism, an influenza virus's success in life is measured by its genetic track record, its ability to pass on genes from one generation to the next.”

“Carbon nanotubes that detect disease-causing mutations developed by Pitt researcher” This reference links to a non-governmental website
(January 25) EurekAlert! reports, “University of Pittsburgh researcher Alexander Star and colleagues at California-based company Nanomix, Inc., have developed devices made of carbon nanotubes that can find mutations in genes causing hereditary diseases, they report in the Jan. 16 issue of the journal Proceedings of the National Academy of Science.”

“Cigarettes, Our Genes Decide How Many We Smoke A Day” This reference links to a non-governmental website
(January 25) Medical News Today reports, “A study to be published in the European Respiratory Journal (ERJ) demonstrates that most Japanese smokers' cigarette consumption is conditioned by their genetic heritage.”

“All-in-one Remote Control Gene Expression Tool, Ecole Polytechnique Fédérale De Lausanne” This reference links to a non-governmental website
(January 24) Medical News Today reports, “In an article appearing online today in the journal Nature Methods, researchers at the EPFL (Ecole Polytechnique Fédérale de Lausanne) unveil a powerful new tool that will facilitate genetic research and open up new avenues for the clinical treatment of genetic disease.”

“Depression more genetic for women”
(January 23) Times Dispatch reports, “Genes contribute more to women's risk of depression than to men's, and different genes may be at work in affected women than in men, a study of more than 42,000 Swedish twins concludes.”

“Genetic technology offers insight into diseases” This reference links to a non-governmental website
(January 23) The Chronicle Online reports, “A physician is faced with the tough decision of whether or not to place a catheter in an elderly patient with a partially clogged artery.”

“Mayo Clinic Collaboration Discovers Protein Amplifies DNA Injury Signals - Cues Genetic Repair Mechanism To Prevent Tumors” This reference links to a non-governmental website
(January 23) Medical News Today reports, “A Mayo Clinic-led research collaboration has discovered that the protein MDC1 amplifies weak DNA injury signals so genetic repair can begin.”

“U of MN researchers identify ataxia gene” This reference links to a non-governmental website
(January 22) EurekAlert! reports, “Researchers at the University of Minnesota Medical School have discovered the gene responsible for a type of ataxia, an incurable degenerative brain disease affecting movement and coordination.”

“Scientists Find Unusual Lung-cancer Tumor-suppressor Gene” This reference links to a non-governmental website
(January 21) Medical News Today reports, “Researchers have identified a new and unusual tumor suppressor gene that may be important in cancers of the lung and head and neck.”

“Study Examines IGF1 Gene, HNPCC, and Colorectal Cancer Risk” This reference links to a non-governmental website
(January 20) Medical News Today reports, “A new study has shown that having a low number of specific sequences of the IGF1 gene called CA-repeats is associated with an increased risk of colorectal cancer in people with the disorder hereditary nonpolyposis colorectal cancer (HNPCC).”

“Researchers at Orion Genomics and University of Glasgow Collaborate to Identify Epigenetic Biomarkers for Early Cancer Diagnosis and Personalized Therapy Selection“ This reference links to a non-governmental website
(January 20) myDNA reports, “Orion Genomics announced today that it has initiated a collaboration with leading researchers at University of Glasgow to discover novel epigenetic biomarkers for the development of tests that screen for cancer at an early stage and provide personalized information about how tumors are most effectively treated.”

“Birth defect gene discovered” This reference links to a non-governmental website
(January 20) myDNA reports, “One out of every 33 babies is born with a birth defect, according to the Centers for Disease Control and Prevention (CDC).”

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Genomics in Scientific Literature
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Singapore Human Mutation/Polymorphism Database: a country-specific database for mutations and polymorphisms in inherited disorders and candidate gene association studies
Tan EC, et al.
Hum Mutat 2006 Jan

The role of genetics and cigarette smoking in the development of pulmonary fibrosis
Steele MP, et al.
Respirology 2006 Jan;11 Suppl 1:S23

Pharmacogenetics, pharmacogenomics and ecogenetics
Motulsky AG & Qi M
J Zhejiang Univ Sci B 2006 Feb;7(2):169-70

Genetics of complex diseases
Motulsky AG
J Zhejiang Univ Sci B 2006 Feb;7(2):167-8

Genomics and world health: hopes and realities
Weatherall D
J Zhejiang Univ Sci B 2006 Feb;7(2):161

Genetic counseling and ethical issues for autism
McMahon WM, et al.
Am J Med Genet C Semin Med Genet 2006 Jan

Autism spectrum disorders: Molecular genetic advances
Bacchelli E & Maestrini E
Am J Med Genet C Semin Med Genet 2006 Jan

2005 Human Genome Variation Society Scientific Meeting
Oetting WS
Hum Mutat 2006 Jan

Family history may be misleading in the diagnosis of Dent's disease
Anglani F, et al.
Urol Res 2006 Jan:1-3

Principal genetic syndromes and autism:from phenotypes,proteins to genes
Hou M, et al.
Beijing Da Xue Xue Bao 2006 Feb;38(1):110-5

Newborn screening of inherited metabolic diseases by tandem mass spectrometry
Yu CL & Gu XF
Beijing Da Xue Xue Bao 2006 Feb;38(1):103-6

Pharmacogenetics and pharmacogenomics: origin, status, and the hope for personalized medicine
Kalow W
Pharmacogenomics J 2006 Jan

Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies
Skol AD, et al.
Nat Genet 2006 Jan

Does use of hormonal contraceptives among women with thrombogenic mutations increase their risk of venous thromboembolism? A systematic review
Mohllajee AP, et al.
Contraception 2006 Feb;73(2):166-78

Screening for the alpha-adducin Gly460Trp variant in hypertensive patients: a cost-effectiveness analysis
Meckley LM & Veenstra DL
Pharmacogenet Genomics 2006 Feb;16(2):139-47

Genetic Aspects of Hyperhomocysteinemia in Chronic Kidney Disease
Sunder-Plassmann G, et al.
Semin Nephrol 2006 Jan;26(1):8-13

Hemochromatosis: genetics and pathophysiology
Beutler E
Annu Rev Med 2006;57:331-47

Pharmacogenomics and individualized drug therapy
Eichelbaum M, et al.
Annu Rev Med 2006 Feb;57:119-37

Results of a randomized study of telephone versus in-person breast cancer risk counseling
Helmes AW, et al.
Patient Educ Couns 2006 Jan

Update on pharmacogenetics in epilepsy: a brief review
Szoeke CE, et al.
Lancet Neurol 2006 Feb;5(2):189-96

Measures of familial aggregation depend on definition of family history: meta-analysis for colorectal cancer
Baglietto L, et al.
J Clin Epidemiol 2006 Feb;59(2):114-24

Cystic Fibrosis Mutations with Widely Variable Phenotype: The D1152H Example
Mussaffi H, et al.
Pediatr Pulmonol 2006 Jan

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending January 25, 2006, there are HuGE articles in the following areas:

Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

 
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Upcoming Events
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New this week

Mechanisms & Models of Cancer This reference links to a non-governmental website (last accessed 2/2008)
August 16-20, 2006 ~ Cold Spring Harbor, NY

Signaling Networks This reference links to a non-governmental website
January 30 - February 4, 2006 ~ Vancouver, Canada

   
Alzheimer's Disease: Genes, Cellular Pathways and Therapies This reference links to a non-governmental website
February 21-26, 2006 ~ Breckenridge, CO, United States
   
  Human Reproductive Health Through the Ages This reference links to a non-governmental website
March 7-10, 2006 ~ Adelaide, Australia
   
New this week Atherothrombosis This reference links to a non-governmental website
April 2-7, 2006 ~ Keystone, Colorado
   
New this week Mutagenesis Gordon Research Conference This reference links to a non-governmental website
August 6-11, 2006 ~ Newport, Rode Island
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Let's Go Surfing
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U.S. Surgeon General’s Family History Initiative-Resource Packet for Health Professionals
This free resource packet has been developed to help health professionals educate the public about the importance of family health history.

Laboratory of Genetics at the University of Wisconsin-Madison This reference links to a non-governmental website
“The Laboratory of Genetics is the oldest and one of the finest genetics centers in the nation.”

CDC’s Coordinating Center for Health Promotion (CoCHP)
CoCHP brings together the resources and missions of the National Center for Chronic Disease Prevention and Health Promotion, including the Office of Genomics and Disease Prevention, and the National Center on Birth Defects and Developmental Disabilities, enabling CDC to better integrate programs, messages to the public, and health policies.

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: January 26, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics