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 Thursday, Feb. 23, 2006     Volume 16   Number 8  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
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Genomics and Public Health - June 4-7, 2006
International Conference on “Genomics and Public Health”
This conference will address key questions relating to genomics and public health, including newborn screening programs, the role of international stakeholders, the role of citizens, and more.  Co-organizers include the University of Montreal,
Centers for Disease Control and Prevention, Public Health Genetics Unit, and the Public Health Agency of Canada. 
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CDC Announcements
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Family history of type 2 diabetes: A population-based screening tool for prevention
Hariri et al.
Genet Med 2006 Feb;8(2):102-108

   
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Inaugural Meeting - CDC Public Health Genomics Collaboration
March 17, 2006 ~ Atlanta, Georgia
Meeting open to CDC employees/contractors only

   
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New HuGE Review
NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis
Franceschini, Nora, et al.
(February 2006)
   
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What's New in HuGENet™
February 2006
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Gene linked to HIV progression among Chinese” This reference links to a non-governmental website
(February 20) SciDev reports, “Researchers in China have identified a human gene that could explain why some Chinese HIV patients develop full-blown AIDS more rapidly than others.”

“Genetic variations help predict risk for salt-induced high blood pressure” This reference links to a non-governmental website
(February 23) News Medical.net reports, “Researchers led by UVa Health System pathologist Robin Felder, Ph.D., have demonstrated that looking for several variations of genes that control blood pressure can predict the risk for high blood pressure caused by high levels of salt.”

“Gene mutation protects fetus from alcohol's effects” This reference links to a non-governmental website
(February 22) Reuters Health reports, “A mutation of an enzyme gene seems to protect the fetus against alcohol consumed by the mother, according to a study of mothers and their infants.”

“Single chip could probe 30,000 genetic conditions”
(February 22) Business Weekly reports, “A software company in Cambridge has branched out to develop a product that could genuinely revolutionise the diagnosis of thousands of serious illnesses.”

“NIH seeks strategies to preserve brain health” This reference links to a non-governmental website
(February 21) EurekAlert reports, “With the rapid aging of the population, the National Institutes of Health (NIH) is intensifying the search for strategies to preserve brain health as people grow older.”

“Gene Patterns In White Blood Cells Quickly Diagnose If Someone Has Been Exposed To A Bioterrorism Agent” This reference links to a non-governmental website
(February 21) Medical News Today reports, “Researchers at Walter Reed Army Institute of Research are developing a method to determine in a matter of hours if someone has been exposed to a bioterrorism agent just by looking at the pattern of active genes in that person's white blood cells.”

“The Epstein Barr Virus (EBV) Slumbers In The Cells Of 90 Per Cent Of The World's Population And Can Activate About 100 Genes” This reference links to a non-governmental website
(February 21) Medical News Today reports, “A detailed structural picture of a molecule that plays a key role in activating the Epstein Barr Virus in human cells has now been obtained by researchers at the European Molecular Biology Laboratory (EMBL) and the Institut de Virologie Moléculaire et Structurale (IVMS), associated with the Université Joseph Fourier and the CNRS, in Grenoble.”

“Gene Mutations May Boost Breast Cancer Risk”
(February 20) Forbes.com reports, “Women with a genetic mutation in one of two related genes are at an increased risk of developing breast cancer, a new study suggests.”

“Scientists link gene to increased risk of Parkinson's in men” This reference links to a non-governmental website
(February 20) BioPortfolio reports, “US-based scientists have discovered a new role for a gene that could explain why men are one and a half times more likely to develop Parkinson's disease than women, researchers announced.”

“The Big Science of Genomics” This reference links to a non-governmental website
(February 20) Duke News reports, “In President Bush’s budget submitted to Congress this week, $40 million was devoted to the "Genes and Environment Initiative," whose goal is "to accelerate discovery of the major genetic factors for diseases that have a substantial public health impact."

“Large European study finds gene variant is no strong risk factor for osteoporosis” This reference links to a non-governmental website
(February 20) EurekAlert! reports, “Variations in a number of different genes and environmental factors affect an individual's risk for osteoporosis.”

“Mapping offers cancer hope”
(February 20) myDNA reports, “Researchers recently identified the genes that predispose some individuals to prostate cancer, marking a scientific breakthrough that could help reduce the number of future deaths.”

“Ernst Mayr's theory illustrated in genetic epidemiology studies” This reference links to a non-governmental website
(February 18) EutekAlert! reports, “The late, famed evolutionary biologist Ernst Mayr's theory of genetic revolution , introduced in 1954, remains controversial to this day and has many detractors.”

“Columbia Receives Up To $15 Million From Spinal Muscular Atrophy Foundation” This reference links to a non-governmental website
(February 17) Columbia University Medical Center reports, “Columbia University has been awarded up to $15 million from the Spinal Muscular Atrophy (SMA) Foundation.”

“Recombinomics Inc. Predicts a New Genetic Change in the H5N1 (Avian Flu) Virus” This reference links to a non-governmental website
(February 17) Yahoo reports, “Recombinomics is issuing a new prediction and warning of a likely alteration in the avian influenza H5N1 hemagglutinin gene.”

“Gene design program from Johns Hopkins simplifies, automates and speeds design of 'artificial' genes” This reference links to a non-governmental website
(February 16) Innovations Report reports, “Johns Hopkins researchers have announced the development of a Web-based, automated computer program that they say greatly simplifies the time-consuming and error-prone process of manually designing artificial pieces of DNA.”

“Chromosome rearrangements not as random as believed” This reference links to a non-governmental website
(February 16) EurekAlert! reports, “As the human genome gradually yields up its secrets, scientists are finding some genetic events, such as rearrangements in chromosomes, are less random than they had previously thought.”

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Genomics in Scientific Literature
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Family history of type 2 diabetes: A population-based screening tool for prevention?
Hariri S, et al.
Genet Med 2006 Feb;8(2):102-8

An approach to the patient with a family history of breast cancer. Benefits, harms and making an informed choice
Kirk J, et al.
Aust Fam Physician 2006 Jan;35(1):43-7

Environmental factors and gene-environment interactions in the aetiology of asthma
Marks GB
Clin Exp Pharmacol Physiol 2006 Mar;33(3):285-9

Genetic research and testing in critical care: Surrogates' perspective*
Freeman BD, et al.
Crit Care Med 2006 Apr;Publish Ahead of Print

Family history of type 2 diabetes: A population-based screening tool for prevention?
Hariri S, et al.
Genet Med 2006 Feb;8(2):102-8

SNP selection at the NAT2 locus for an accurate prediction of the acetylation phenotype
Sabbagh A & Darlu P
Genet Med 2006 Feb;8(2):76-85

Pooled DNA genotyping on Affymetrix SNP genotyping arrays
Kirov G, et al.
BMC Genomics 2006 Feb;7(1):27

Ischemic stroke as a complex genetic disorder
Meschia JF
Semin Neurol 2006 Mar;26(1):49-56

Single-gene stroke disorders
Majersik JJ & Skalabrin EJ
Semin Neurol 2006 Mar;26(1):33-48

Fifty years of genetic epidemiology, with special reference to Japan
Morton NE
J Hum Genet 2006 Feb

Screening for hemochromatosis in asymptomatic subjects with or without a family history
Powell LW, et al.
Arch Intern Med 2006 Feb;166(3):294-301

Interethnic Differences in Genetic Polymorphisms of CYP2D6 in the U.S. Population: Clinical Implications
Bernard S, et al.
Oncologist 2006 Feb;11(2):126-35

Genetics of allergic disease
Steinke JW & Borish L
Med Clin North Am 2006 Jan;90(1):1-15

Candidate gene association studies and evidence for gene-by-gene interactions
Kabesch M
Immunol Allergy Clin North Am 2005 Nov;25(4):681-708

           
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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending February 22, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

 
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Upcoming Events
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New this week

1st Pan Arab Human Genetics Conference This reference links to a non-governmental website
April 4-6, 2006 ~ Dubai, United Arab Emirates

Cancer Susceptibility and Cancer Susceptibility Syndromes This reference links to a non-governmental website
March 1-5, 2006 ~ Maui, HI

   
New this week Birth Defects In Texas: Research Symposium 2006
April 19, 2006 ~ Austin, Texas
   
  The 2006 CDC Diabetes and Obesity Conference This reference links to a non-governmental website
May 16-19, 2006 ~ Denver, Colorado
   
New this week The International Conference on Proteomics: "Bridging the Gap Between Gene Expression and Biological Function" This reference links to a non-governmental website
October 11-14, 2006 ~ Luxembourg
   
 

From Genomes to Protective Antigens – Designing Vaccines This reference links to a non-governmental website
November 15-17, 2006 ~ Prague, Czech Republic

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Let's Go Surfing
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GeNeYouS (Genomics Network for Young Scientists) This reference links to a non-governmental website
From Genomes to Protective Antigens, GeNeYouS offers a platform for information exchange between scientists working in the fast evolving field of genomics.

Collaboration Education and Test Translation Program (CETT) This reference links to a non-governmental website
The Collaboration, Education, and Test Translation (CETT) Program for Rare Genetic Diseases was developed by the NIH Office of Rare Diseases. 

Centre for Society and Genomics This reference links to a non-governmental website
The objective of the Centre for Society and Genomics is to assess and influence the societal impact of genomics.

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: February 23, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics