Centers for Disease Control and Prevention Centers for Disease Control and Prevention CDC Home Search CDC CDC Health Topics A-Z site search
National Office of Public Health Genomics
Centers for Disease Control and Prevention
Office of Genomics and Disease Prevention
Site Search
 
     
 Thursday, Dec. 28, 2006     Volume 17   Number 25  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
Happy Holidays!
The NOPHG staff wishes you a wonderful holiday season!
Spotlight
view the current Update
2006 Program Review Book

CDC’s National Office of Public Health Genomics (NOPHG) is pleased to announce the 2006 Program Review Book is now available online.

line
   
CDC Announcements
back to top
bullhorn

The Emergence of Networks in Human Genome Epidemiology: Challenges and
Opportunities

Daniela Seminara, et al
Epidemiology 2007 Jan;18(1):1-8

line
Genomics In The News
back to top
  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
light bulb
Featured item

“Researchers Find That a ‘Silent’ Gene Mutation Can Change the Function of an Anticancer Drug Pump”  This reference links to a non-governmental website
(Dec 21) NIH News reports, “A genetic mutation that does not cause a change in the amino acid sequence of the resulting protein can still alter the protein’s expected function, according to a new study conducted at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH).”

“Do Sudden-Death Genes Strike Women Most?”  This reference links to a non-governmental website
(Dec 27) CBS News reports, “Women are more likely than men to carry -- and to pass on -- mutant genes that cause long-QT syndrome, a defect in the heart's electrical system linked to sudden death, according to new research.”

“Gene discovered for form of brittle bone disease”  This reference links to a non-governmental website
(Dec 27) EurekAlert! reports, “Researchers at the National Institutes of Health have discovered that a previously unexplained fatal form of Osteogenesis Imperfecta--a disorder that weakens bones and which may cause frequent fractures--results from a genetic defect in a protein involved in the production of collagen.”

“Inflammatory genes linked to salt-sensitive hypertension”  This reference links to a non-governmental website (last accessed 2/2008)
(Dec 27) Medical College of Georgia reports, “One key to your high blood pressure might just be your inflammatory genes.”

“VA to launch large-scale genetic data collection”  This reference links to a non-governmental website (last accessed 2/2008)
(Dec 27) Government Health IT reports, “Aiming for breakthroughs in genomic medicine, the Department of Veterans Affairs has begun collecting genetic information from patients and will link the information to each patient’s electronic health record.”

“HIV-1 Kills Immune Cells In The Gut That May Never Bounce Back”  This reference links to a non-governmental website
(Dec 27) Science Daily reports, “People with HIV have been living longer, healthier lives since the development of highly active antiretroviral therapy (or HAART) in 1995.”

“Genetic Mechanism Helps Explain Chronic Pain Disorders”  This reference links to a non-governmental website
(Dec 27) Medical News Today reports, “Researchers at the University of North Carolina at Chapel Hill have discovered that commonly occurring variations of a gene trigger a domino effect in chronic pain disorders.”

“Longevity Gene Delays Alzheimer's And Preserves Faculties”  This reference links to a non-governmental website
(Dec 27) Medical News Today reports, “A US study has linked a gene that helps people live longer to increased mental ability and delayed onset of Alzheimer's Disease.”

“Genetic Map Offers New Tool For Malaria Research”  This reference links to a non-governmental website
(Dec 26) Medical News Today reports, “An international research team announced today the completion of a genome-wide map that charts the genetic variability of the human malaria parasite Plasmodium falciparum.”

“Gene Which Causes Nystagmus, A Distressing Eye Condition, Identified By Researchers At The University Of Leicester”  This reference links to a non-governmental website
(Dec 25) Medical News Today reports, “Researchers at the University of Leicester have identified for the first time a gene which causes a distressing eye condition.”

“Genetically Modified Cells Attack Tumors”  This reference links to a non-governmental website
(Dec 23) Medical News Today reports, “Neuroblastoma tumors have been successfully treated in the lab with genetically modified cells that sought out and activated a chemotherapy drug placed directly at the cancer cells, according to investigators at St. Jude Children's Research Hospital and their colleagues at City of Hope National Medical Center (Duarte, CA) and the University of British Columbia (Vancouver, Canada).”

“Feinstein Institute and Cold Spring Harbor Lab join forces, seek manic depression genes”  This reference links to a non-governmental website
(Dec 21) EurekAlert! reports, “Psychiatry and genetics researchers tackle the genetics of early-onset bipolar disorder in children and adolescents.”

“Genetics behind human eye colour identified”
(Dec 21) newKerala.com reports, “Scientists from Queensland, Australia, claim to having made a breakthrough in the understanding of the genetics behind human eye colour.”

line
Genomics in Scientific Literature
back to top
light bulb
Featured item
CDC-sponsored material The Emergence of Networks in Human Genome Epidemiology: Challenges and Opportunities you will need a free Acrobat reader to view this file(111 KB)
Seminara D, et al.
Epidemiology 2007 Jan;18(1):1-8

Predicting risk of breast cancer recurrence using gene-expression profiling
Ignatiadis M & Desmedt C
Pharmacogenomics 2007 Jan;8(1):101-11

Pattern-recognition techniques with haplotype analysis in pharmacogenomics
Lin E, et al.
Pharmacogenomics 2007 Jan;8(1):75-83

The genetics of fibromyalgia syndrome
Buskila D, et al.
Pharmacogenomics 2007 Jan;8(1):67-74

Vascular endothelial growth factor pharmacogenetics: a new perspective for anti-angiogenic therapy Pasqualetti G, et al.
Pharmacogenomics 2007 Jan;8(1):49-66

Unraveling the genetics of atherosclerosis: implications for diagnosis and treatment
Seo DM & Goldschmidt-Clermont PJ
Expert Rev Mol Diagn 2007 Jan;7(1):45-51

Exact Tests of Hardy-Weinberg Equilibrium and Homogeneity of Disequilibrium across Strata
Schaid DJ, et al.
Am J Hum Genet 2006 Dec;79(6):1071-80

Powerful multilocus tests of genetic association in the presence of gene-gene and gene-environment interactions
Chatterjee N, et al.
Am J Hum Genet 2006 Dec;79(6):1002-16

The role of National Library of Medicine(R) websites in newborn screening education
Fomous C & Miller N
Ment Retard Dev Disabil Res Rev 2006 Dec;12(4):305-12

Molecular Genetic Findings in Suicidal Behavior: What is Beyond the Serotonergic System?
Rujescu D, et al.
Arch Suicide Res 2007;11(1):17-40

Genomics and public health at CDC
Gwinn M, et al.
MMWR Morb Mortal Wkly Rep 2006 Dec;55 Suppl 2:20-1

Using genetic variation to optimize nutritional preemption
Gillies PJ & Krul ES
J Nutr 2007 Jan;137(1):270S-4S

Cytokine gene polymorphisms, cancer susceptibility, and prognosis
Howell WM & Rose-Zerilli MJ
J Nutr 2007 Jan;137(1):194S-9S

Diagnostic Interview for Genetic Studies (DIGS): Inter-rater and test-retest reliability and validity in a Spanish population
Roca M, et al.
Eur Psychiatry 2006 Dec

Family History
back to top

“First Familial Pancreatic Cancer Gene Identified”  This reference links to a non-governmental website
(Dec 28) Medical News Today reports, “Pancreatic cancer is relatively rare but deadly; most patients die within a year of diagnosis, and it is the fourth leading cause of cancer deaths in the US.”

Factors influencing participation in cutaneous screening among individuals with a family history of melanoma
Azzarello LM & Jacobsen PB
J Am Acad Dermatol 2006 Dec

Associations Between Family History of Allergy, Exposure to Tobacco Smoke, Active Smoking, Obesity, and Asthma in Adolescents
Vazquez Nava F, et al.
Arch Bronconeumol 2006 Dec;42(12):621-6

Cascade screening for familial hypercholesterolaemia: implications of a pilot study for national screening programmes
Marks D, et al.
J Med Screen 2006;13(3):156-9

Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10,211 cases and 11,905 controls from the InterLymph Consortium
Wang SS, et al.
Blood 2006 Dec

Genetic Testing
back to top

“Profiling of cancer genes may lead to better and earlier detection”  This reference links to a non-governmental website
(Dec 25) EurekAlert! reports, “A research team at UT Southwestern Medical Center has for the first time identified several genes whose expression is lost in four of the most common solid human
cancers – lung, breast, prostate and colon cancer.”

“Researchers make progress in studying genetic traits of India-born populations”  This reference links to a non-governmental website
(Dec 21) EurekAlert! reports, “Despite the fact that the people of India constitute more than one-sixth of the world's entire population, they have been underrepresented in studies related to genetic diseases.”

Iron Overload (with Attention to Genetic Testing and Diagnosis/Management of HFE Wild Type Patients)
Siddaiah N & Kowdley KV
Curr Treat Options Gastroenterol 2006 Dec;9(6):447-55

Mutations causing biotinidase deficiency in children ascertained by newborn screening in Western Hungary
Milankovics I, et al.
Mol Genet Metab 2006 Dec

Pharmacogenetics of irinotecan: clinical perspectives on the utility of genotyping
Innocenti F & Ratain MJ
Pharmacogenomics 2006 Dec;7(8):1211-21

Overview of the pharmacoeconomics of pharmacogenetics
Dervieux T & Bala MV
Pharmacogenomics 2006 Dec;7(8):1175-84

NICHD research initiative in newborn screening
Alexander D & Hanson JW
Ment Retard Dev Disabil Res Rev 2006 Dec;12(4):301-4

Universal newborn screening and adverse medical outcomes: A historical note
Brosco JP, et al.
Ment Retard Dev Disabil Res Rev 2006 Dec;12(4):262-9

Making the case for objective performance metrics in newborn screening by tandem mass spectrometry
Rinaldo P, et al.
Ment Retard Dev Disabil Res Rev 2006 Dec;12(4):255-61

Current status of newborn screening: Decision-making about the conditions to include in screening programs
Watson MS
Ment Retard Dev Disabil Res Rev 2006 Dec;12(4):230-5

Pilot programs in newborn screening
Pass K, et al.
Ment Retard Dev Disabil Res Rev 2006 Dec;12(4):293-300

Changing perspectives on the benefits of newborn screening
Bailey DB Jr, et al.
Ment Retard Dev Disabil Res Rev 2006 Dec;12(4):270-9

The clinical aspects of newborn screening: Importance of newborn screening follow-up
James PM & Levy HL
Ment Retard Dev Disabil Res Rev 2006 Dec;12(4):246-54

National evaluation of US newborn screening system components
Therrell BL & Hannon WH
Ment Retard Dev Disabil Res Rev 2006 Dec;12(4):236-45

Critical role of the March of Dimes in the expansion of newborn screening
Howse JL, et al.
Ment Retard Dev Disabil Res Rev 2006 Dec;12(4):280-7

line
HuGE Published Literature
back to top

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending December 27, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

line
Upcoming Events
back to top

Click here for more information about upcoming events.

light bulb
Featured item
Pharmacogenomics  This reference links to a non-governmental website (last accessed 2/2008)
February 1-2, 2007 ~ Bethesda, MD
 

Screening Europe This reference links to a non-governmental website
February 20-21, 2007 ~ Barcelona, Spain

   
New This Week

Short Course 2007of National Society of Genetic Counselors This reference links to a non-governmental website
October 11-12, 2007 ~ Kansas City, MO

   
New This Week

26th Annual Education Conference of the National Society of Genetic Counselors This reference links to a non-governmental website
October 12-16, 2007 ~ Kansas City, MO

line
 
Let's Go Surfing
back to top
light bulb
Featured item

Finding Reliable Health Information Online
Tips from the National Genome Research Institute

Human genome  This reference links to a non-governmental website
Wikipedia, the free encyclopedia

Create a DNA Fingerprint  This reference links to a non-governmental website
By Rick Groleau

 

Send websites that you would like to see included in a future update to genetics@cdc.gov

To receive notification of this update by e-mail, please send the following message:
To: listserv@listserv.cdc.gov
Subject: (leave blank)
Message: subscribe genetics

The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: December 28, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics